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List of works by Thorsten Stiewe

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

article

A cisplatin-resistant head and neck cancer cell line with cytoplasmic p53(mut) exhibits ATP-binding cassette transporter upregulation and high glutathione levels.

scientific article

A new therapeutic approach in medullary thyroid cancer treatment: inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant.

scientific article

A transcriptome-based global map of signaling pathways in the ovarian cancer microenvironment associated with clinical outcome

scientific article published on 23 May 2016

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.

scientific article published on 15 December 2011

Altered glycogen metabolism causes hepatomegaly following an Atg7 deletion.

scientific article published on 23 August 2016

Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model.

scientific article published in July 2003

C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity

scientific article published on 11 February 2008

CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.

scientific article published on 6 September 2017

CRISPR-Cas9-based target validation for p53-reactivating model compounds.

scientific article published on 23 November 2015

Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.

scientific article

Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression

scientific article published on 25 June 2019

Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites

scientific article published on 27 June 2018

Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1.

scientific article published on 20 February 2018

Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor

scientific article published on 30 June 2019

DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.

scientific article published in May 2010

Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.

scientific article

Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner

scientific article published on 07 November 2019

E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products.

scientific article

Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance

scientific article published on 13 October 2016

Epigenetic Inactivation of the Tumor Suppressor <i>IRX1</i> Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis

scientific article published on 26 November 2020

Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53

scientific article published on 14 August 2019

Extracellular Vesicles: Messengers of p53 in Tumor-Stroma Communication and Cancer Metastasis

scientific article published on 17 December 2020

Galectin-3 interacts with components of the nuclear ribonucleoprotein complex.

scientific article

Gene expression changes in response to E2F1 activation.

scientific article

Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes

scientific article published on 01 September 2018

Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response

scientific article published on 01 September 2018

How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance

scientific article published on 09 May 2018

IRF8 Is an AML-Specific Susceptibility Factor That Regulates Signaling Pathways and Proliferation of AML Cells

scientific article published on 12 February 2021

Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma

scientific article published on 28 September 2015

Improved treatment of pancreatic cancer by IL-12 and B7.1 costimulation: antitumor efficacy and immunoregulation in a nonimmunogenic tumor model.

scientific article

In good times and bad: p73 in cancer.

scientific article published on 16 June 2008

Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo

scientific article published on 21 November 2019

Increased DeltaN-p73 expression in tumors by upregulation of the E2F1-regulated, TA-promoter-derived DeltaN'-p73 transcript

scientific article published on 01 May 2003

Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo.

scientific article

Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients

scientific article

KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment

scientific article

LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution

scientific article published on 13 May 2020

Life or death: p53-induced apoptosis requires DNA binding cooperativity.

scientific article published on 11 October 2010

Loss of p53 function at late stages of tumorigenesis confers ARF-dependent vulnerability to p53 reactivation therapy

scientific article published on 14 October 2019

Lung tumors on multimodal radiographs derived from grating-based X-ray imaging--a feasibility study

scientific article published on 7 December 2013

MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6.

scientific article

Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE

scientific article

Mechanism of E2F1-induced apoptosis in primary vascular smooth muscle cells.

scientific article

Miz1 Controls Schwann Cell Proliferation via H3K36me2 Demethylase Kdm8 to Prevent Peripheral Nerve Demyelination.

scientific article published on 7 December 2017

Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases

scientific article

Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.

scientific article

NFATc1 as a therapeutic target in FLT3-ITD-positive AML.

scientific article published on 14 April 2015

Oncogenic NRAS Primes Primary Acute Myeloid Leukemia Cells for Differentiation

scientific article published on 22 April 2015

Oncogenic RAS enables DNA damage- and p53-dependent differentiation of acute myeloid leukemia cells in response to chemotherapy

scientific article

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

scientific article published in Nature Communications

Pro-metastatic p53 mutants control folding of N-glycoproteins

scientific article published on 6 February 2017

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment

scientific article published on 15 November 2017

Quantitative TP73 transcript analysis in hepatocellular carcinomas.

scientific article published on January 2004

Regulation of telomerase activity by the p53 family member p73.

scientific article published in February 2006

Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

scientific article published on 05 June 2020

Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses

scientific article published on 04 September 2019

Role of p73 in malignancy: tumor suppressor or oncogene?

scientific article

Role of the p53-homologue p73 in E2F1-induced apoptosis

scientific article published on December 2000

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

scientific article published on 22 March 2019

Sorafenib induces paradoxical phosphorylation of the extracellular signal-regulated kinase pathway in acute myeloid leukemia cells lacking FLT3-ITD mutation

scientific article

Targeting p73 in cancer.

scientific article published on 22 August 2011

The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

scientific article published on 29 July 2020

The multicellular signalling network of ovarian cancer metastases

scientific article published on 01 November 2021

The p53 family in differentiation and tumorigenesis.

scientific article published in February 2007

The p53 family inhibitor DeltaNp73 interferes with multiple developmental programs.

scientific article published in January 2006

The pan-deacetylase inhibitor panobinostat suppresses the expression of oncogenic miRNAs in hepatocellular carcinoma cell lines

scientific article published on 23 December 2013

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

scientific article published in Nature Communications

The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state

scientific article published on 30 April 2015

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization.

scientific article published on 21 September 2016

Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction.

scientific article

Transactivation-deficient DeltaTA-p73 acts as an oncogene.

scientific article published on July 2002

Transcription factor Sp2 potentiates binding of the TALE homeoproteins Pbx1:Prep1 and the histone-fold domain protein Nf-y to composite genomic sites

scientific article published in Journal of Biological Chemistry

YM155-Adapted Cancer Cell Lines Reveal Drug-Induced Heterogeneity and Enable the Identification of Biomarker Candidates for the Acquired Resistance Setting

scientific article published on 26 April 2020

ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer.

scientific article

Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3.

scientific article published on 20 March 2015

iTRAQ analysis of a cell culture model for malignant transformation, including comparison with 2D-PAGE and SILAC.

scientific article published on 23 March 2012

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

scientific article published on 17 September 2020

p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo.

scientific article published on 9 May 2013

p53 and p73 in suppression of Myc-driven lymphomagenesis.

scientific article

p53 family members in myogenic differentiation and rhabdomyosarcoma development

scientific article

p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding.

scientific article published on 3 February 2017

p53's Extended Reach: The Mutant p53 Secretome

scientific article published on 15 February 2020

p73 poses a barrier to malignant transformation by limiting anchorage-independent growth

scientific article published on 31 January 2008

ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma

scientific article published on 26 January 2016

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