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List of works by David Klein

A Diurnal Melatonin Rhythm in Primate Cerebrospinal Fluid* ⬇️

scientific article published on February 1, 1979

A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland

scientific article

A simple and rapid method for the purification of ovine pineal arylalkylamine N-acetyltransferase

scientific article published on 01 February 1987

Activation of pineal and brain acetyl-CoA hydrolase by cystamine: An apparent case of disulfide exchange ⬇️

scientific article published on December 14, 1979

Adrenergic stimulation of rat pineal hydroxyindole-O-methyltransferase

scientific article published on 01 April 1983

Alpha-adrenergic potentiation of beta-adrenergic stimulation of rat pineal N-acetyltransferase. Studies using cirazoline and fluorine analogs of norepinephrine.

scientific article published on December 1984

Arginine vasotocin: effects on development of reproductive organs

scientific article published on 01 December 1974

Arylalkylamine N-acetyltransferase: "the Timezyme".

scientific article

Atypical synergistic alpha 1- and beta-adrenergic regulation of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in rat pinealocytes.

scientific article published in June 1985

Beta adrenergic-blockers decrease adrenergically stimulated N-acetyltransferase activity in pineal glands in organ culture

scientific article published on June 1, 1976

Beta-adrenergic receptor control of rat pineal hydroxyindole-O-methyltransferase.

scientific article published on July 1983

Biosynthesis and release of glycoproteins by pineal gland in organ culture ⬇️

scientific article published on March 30, 1972

Biosynthesis of biopterin: adrenergic cyclic adenosine monophosphate-dependent inhibition in the pineal gland

scientific article published in Science

CLOCK and NPAS2 have overlapping roles in the circadian oscillation of arylalkylamine N-acetyltransferase mRNA in chicken cone photoreceptors.

scientific article

Calcium potentiates cyclic AMP stimulation of pineal arylalkylamine N-acetyltransferase.

scientific article published in April 1993

Cardiac glycosides stimulate phospholipase C activity in rat pinealocytes

scientific article published on 01 February 1987

Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation.

scientific article published on 26 October 2003

Characterization of alpha 2-adrenergic receptors on rat pinealocytes.

scientific article published in May 1992

Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87).

scientific article

Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture.

scientific article published in January 1997

Chick pineal melatonin synthesis: light and cyclic AMP control abundance of serotonin N-acetyltransferase protein.

scientific article published in June 2000

Circadian Expression of Transcription Factor Fra-2 in the Rat Pineal Gland ⬇️

scientific article published on November 10, 1995

Circadian changes in long noncoding RNAs in the pineal gland.

scientific article

Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina.

scientific article

Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland

scientific article published on 30 December 2019

Crx broadly modulates the pineal transcriptome.

scientific article

Cyclic AMP-induced release of [14C]taurine from pinealocytes ⬇️

scientific article published on September 12, 1979

Daily Rhythm in Plasma N-acetyltryptamine.

scientific article published on May 2017

Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant.

scientific article published on 4 January 2007

Daily rhythms in cortisol and melatonin in primate cerebrospinal fluid. Effects of constant light and dark

scientific article published on 01 April 1981

Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity.

scientific article published on 11 May 2009

Development of MEKA (phosducin), G beta, G gamma and S-antigen in the rat pineal gland and retina.

scientific article published in July 1992

Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells

scientific journal article

Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling

scientific journal article

Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus

scientific article published on 01 January 2000

Dopaminergic neurons in explants of substantia nigra in culture.

scientific article published in January 1973

Drastic neofunctionalization associated with evolution of the timezyme AANAT 500 Mya

scientific article

Dual receptor regulation of cyclic nucleotides: alpha 1-adrenergic potentiation of vasoactive intestinal peptide stimulation of pinealocyte adenosine 3',5'-monophosphate.

scientific article

Effect of norepinephrine on the concentration of adenosine 3',5'-monophosphate of rat pineal gland in organ culture.

scientific article published in June 1972

Effects of selected treatments on stability and activity of pineal serotonin N-acetyltransferase

scientific article published on 01 September 1979

Effects on fluorine analogs of norepinephrine on stimulation of cyclic adenosine 3',5'-monophosphate and binding to beta-adrenergic receptors in intact pinealocytes

scientific article published on 01 May 1981

Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug

scientific article published on 13 December 2006

Evidence for the placental transfer of 3 H-acetyl-melatonin

scientific article

Evidence for the secretion of thyrocalcitonin at normal and subnormal plasma calcium levels.

scientific article published in January 1968

Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87).

scientific article published on 24 March 2008

Evolution of AANAT: expansion of the gene family in the cephalochordate amphioxus

scientific article

Evolution of arylalkylamine N-acetyltransferase: emergence and divergence.

scientific article

Evolution of melatonin as a night signal: Contribution from a primitive photosynthetic organism.

scientific article published in June 1992

Female-specific induction of rat pituitary dentin matrix protein-1 by GnRH.

scientific article published on October 2013

Forskolin stimulates pinealocyte cGMP accumulation. Dramatic potentiation by an alpha 1-adrenergic----[Ca2+]i mechanism involving protein kinase C

scientific article published on 01 June 1989

Genetic, temporal and developmental differences between melatonin rhythm generating systems in the teleost fish pineal organ and retina.

scientific article

Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior

scientific article

Global daily dynamics of the pineal transcriptome.

scientific article published on 08 February 2011

Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells

scientific article published on 01 October 1995

Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA

scientific article

Hydroxyindole-O-methyltransferase in Y-79 cells: regulation by serum.

scientific article

Immunocytochemical demonstration of retinal S-antigen in the pineal organ of four mammalian species.

scientific article published in January 1985

Immunocytochemical demonstration of rod-opsin, S-antigen, and neuron-specific proteins in the human pineal gland

scientific article published on March 1, 1992

Immunoreactive S-antigen in cerebrospinal fluid: a marker of pineal parenchymal tumors?

scientific article published on 01 May 1989

Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N -Acetyltransferase ⬇️

scientific article published on September 11, 1970

Induction of adrenal tyrosine hydroxylase in organ culture

scientific article published on 01 September 1972

Inhibition of thein VitroPituitary Response to Luteinizing Hormone-Releasing Hormone by Melatonin, Serotonin, and 5-Methoxytryptamine1 ⬇️

scientific article published on March 1, 1977

Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87)

scientific article

Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic leads to spinal cord circuit in the melatonin rhythm generating system

scientific article published on 01 May 1983

Long-term organ culture of rat anterior pituitary glands.

scientific article published in November 1976

Maternal-fetal transfer of melatonin in the non-human primate

scientific article published on June 1, 1979

Mechanism of melatonin signal transduction in the neonatal rat pituitary

scientific article published on 01 September 1995

Melatonin Synthesis: Acetylserotonin O-Methyltransferase (ASMT) Is Strongly Expressed in a Subpopulation of Pinealocytes in the Male Rat Pineal Gland.

scientific article published on 7 March 2016

Melatonin inhibition of the in vivo pituitary response to luteinizing hormone-releasing hormone in the neonatal rat

scientific article published on 01 July 1980

Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor

scientific article published on January 23, 1976

Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells ⬇️

scientific article published on February 1, 1992

Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87).

scientific article published in October 2002

Melatonin synthesis in retina: cAMP-dependent transcriptional regulation of chicken arylalkylamine N-acetyltransferase by a CRE-like sequence and a TTATT repeat motif in the proximal promoter.

scientific article

Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205.

scientific article

Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland

scientific journal article

Melatonin synthesis: arylalkylamine N-acetyltransferases in trout retina and pineal organ are different

scientific article published on 01 February 2000

MicroRNAs in the pineal gland: miR-483 regulates melatonin synthesis by targeting arylalkylamine N-acetyltransferase

scientific article

Mitogen-activated protein kinase phosphatase-1 (MKP-1): >100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland

scientific journal article

Molecular evolution of multiple arylalkylamine N-acetyltransferase (AANAT) in fish.

scientific article

Monoamine oxidase in rat placenta, human placenta, and cultured choriocarcinoma.

scientific article

Multiple forms of arylalkylamine N-acetyltransferases in the rat pineal gland: purification of one molecular form.

scientific article published in January 1987

Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism

scientific article published on 19 May 2009

Neonatal rat pinealocytes: typical and atypical characteristics of [125I]iodohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation

scientific article published on 01 February 1981

Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?

scientific article published on 29 August 2007

NeuroD1 is required for survival of photoreceptors but not pinealocytes: results from targeted gene deletion studies.

scientific article

Noradrenergic control of the synthesis of two rat pineal proteins.

scientific article published in May 1990

Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.

scientific article

Norepinephrine stimulates potassium efflux from pinealocytes: evidence for involvement of biochemical "AND" gate operated by calcium and adenosine 3',5'-monophosphate.

scientific article

On GABA function and physiology in the pineal gland

scientific article published on December 24, 1976

Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat.

scientific article published on 19 March 2007

Ontogeny of the pineal melatonin rhythm in the Syrian (Mesocricetus auratus) and Siberian (Phodopus sungorus) hamsters and in the rat

scientific article published on 01 October 1980

Phosphatidylinositol phosphodiesterase (phospholipase C) activity in the pineal gland: characterization and photoneural regulation

scientific article published on 01 April 1987

Photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells

scientific article published on 01 September 2006

Photic regulation of the melatonin rhythm: monkey and man are not the same

scientific article published on 01 January 1980

Photoneural Control of the Synthesis and Phosphorylation of Pineal MEKA (Phosducin) ⬇️

scientific article published on December 1, 1991

Pineal N-acetyltransferase Activity in Blinded and Anosmic Male Rats12 ⬇️

scientific article published on October 1, 1971

Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus

scientific article published on 01 October 1979

Pineal N-acetyltransferase is inactivated by disulfide-containing peptides: insulin is the most potent

scientific article published on 01 July 1981

Pineal Serotonin N -Acetyltransferase Activity: Abrupt Decrease in Adenosine 3′,5′-Monophosphate May Be Signal for "Turnoff" ⬇️

scientific article published on January 20, 1978

Pineal function: impact of microarray analysis

scientific article

Pineal hydroxyindole-O-methyl transferase activity in the growing rat.

scientific article published in June 1969

Pineal nitric oxide synthase: characteristics, adrenergic regulation and function ⬇️

scientific article published on July 18, 1994

Pineal-specific expression of green fluorescent protein under the control of the serotonin-N-acetyltransferase gene regulatory regions in transgenic zebrafish

scientific article (publication date: November 2002)

Postsynaptic alpha-adrenergic receptors potentiate the beta-adrenergic stimulation of pineal serotonin N-acetyltransferase.

scientific article published on January 1983

Preliminary observations on the reproductive effects of the pineal gland in blinded, anosmic male rats ⬇️

scientific article

Prostaglandins: stimulation of bone resorption in tissue culture

scientific article published on 01 June 1970

RGS2 is a feedback inhibitor of melatonin production in the pineal gland.

scientific article

Rapid Light-Induced Decrease in Pineal Serotonin N -Acetyltransferase Activity ⬇️

scientific article published on August 11, 1972

Rapid and reversible activation of acetyl CoA hydrolase in intact pineal cells by disulfide exchange

scientific article published on 01 September 1980

Rapid nocturnal increase in ovine pineal N-acetyltransferase activity and melatonin synthesis: effects of cycloheximide.

scientific article published in September 1985

Rat arylalkylamine N-acetyltransferase gene: upstream and intronic components of a bipartite promoter

scientific article published on 01 December 1999

Rat pineal Gsa, Gia and Goa: relative abundance and development ⬇️

scientific article published on February 14, 1992

Rat pineal S-antigen: sequence analysis reveals presence of alpha-transducin homologous sequence

scientific article published on 01 April 1989

Rat pineal alpha 1-adrenoceptor subtypes: studies using radioligand binding and reverse transcription-polymerase chain reaction analysis.

scientific article published in July 1996

Rat pineal alpha 1-adrenoceptors: identification and characterization using [125I]iodo-2-[beta-(4-hydroxyphenyl)-ethylaminomethyl]tetralone

scientific article published on 01 February 1984

Rax : developmental and daily expression patterns in the rat pineal gland and retina.

scientific article

Reciprocal Day/Night Relationship between Serotonin Oxidation and N-Acetylation Products in the Rat Pineal Gland* ⬇️

scientific article published on November 1, 1983

Recoverin in pineal organs and retinae of various vertebrate species including man

scientific article published on November 6, 1992

Regulation of "peripheral-type" binding sites for benzodiazepines in the pineal gland.

scientific article published in December 1984

Regulation of Pineal Melatonin in the Syrian Hamster ⬇️

scientific article published on February 1, 1979

Regulation of pineal rhythms in chickens: effects of blinding, constant light, constant dark, and superior cervical ganglionectomy

scientific article published on December 1, 1975

Regulation of pineal rhythms in chickens: refractory period and nonvisual light perception

scientific article published on April 1, 1975

Regulation of rat pineal hydroxyindole-O-methyltransferase in neonatal and adult rats.

scientific article published in June 1983

Relation of the pineal gland and environmental lighting to thyroid function in the rat.

scientific article published in January 1970

Role of adenosine-3',5'-monophosphate in the hormonal regulation of bone resorption: studies with cultured fetal bone

scientific article published on 01 September 1971

S-antigen-like immunoreactivity in a human pineocytoma.

scientific article published in January 1986

Seesaw signal processing in pineal cells: homologous sensitization of adrenergic stimulation of cyclic GMP accompanies homologous desensitization of beta-adrenergic stimulation of cyclic AMP.

scientific article

Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: an example from the pineal gland

scientific article published on 01 November 2000

Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism

scientific journal article

Serum melatonin and pineal indoleamine metabolism in a species with a small day/night N-acetyltransferase rhythm.

scientific article published in January 1985

Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression

scientific article published in PLoS ONE

Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells

scientific article published on August 1, 1992

Starting the zebrafish pineal circadian clock with a single photic transition.

scientific article published on 23 February 2006

Stimulation of the paraventricular nucleus area of the hypothalamus elevates urinary 6-hydroxymelatonin during daytime

scientific article published on 01 July 1987

Stimulus deprivation increases pineal Gs alpha and G beta

scientific article published on October 1, 1992

Studies on the daily pattern of pineal melatonin in the Syrian hamster

scientific article published on 01 November 1980

Sympathetic nerve endings in the pineal gland protect against acute stress-induced increase in N-acetyltransferase (EC 2.3.1.5.) activity

scientific article published on September 1, 1976

Taurine release from the pineal-gland is stimulated via a beta-adrenergic mechanism

scientific article published on 01 April 1980

Taurine: Stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism ⬇️

scientific article published on April 20, 1979

The Lhx4 homeobox transcript in the rat pineal gland: Adrenergic regulation and impact on transcripts encoding melatonin-synthesizing enzymes

scientific article published on 11 November 2019

The Lhx9 homeobox gene controls pineal gland development and prevents postnatal hydrocephalus

scientific article

The effects of environmental lighting on the daily melatonin rhythm in primate cerebrospinal fluid.

scientific article published in November 1981

The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression

scientific article

The melatonin rhythm generating system: developmental aspects.

scientific article published on May 1981

The pineal adrenergic----cyclic GMP response develops two weeks after the adrenergic----cyclic AMP response

scientific article published on July 24, 1992

The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex

scientific journal article

Thin-layer chromatographic separation of pineal gland derivatives of serotonin-14C.

scientific article published in October 1969

Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4).

scientific article published on 29 May 2009

Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2

scientific journal article

Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream.

scientific article published on January 2007

Transcriptome analysis of the zebrafish pineal gland ⬇️

scientific article (publication date: July 2009)

Use of charcoal adsorption for the microassay of Acetyl-CoA hydrolase ⬇️

scientific article published on March 1, 1979

Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity ⬇️

scientific article published on May 10, 1974

Zebrafish serotonin-N-acetyltransferase-2 gene regulation: pineal-restrictive downstream module contains a functional E-box and three photoreceptor conserved elements

scientific article (publication date: May 2004)

[3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland

scientific article published on 01 February 1989

cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation

scientific article

pY RNA1-s2: a highly retina-enriched small RNA that selectively binds to Matrin 3 (Matr3)

scientific article

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