List of works - Sophie Broutin

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

scientific article published on 13 February 2017

Aggressive inherited and sporadic medullary thyroid carcinomas display similar oncogenic pathways.

scientific article

Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer

scientific article published on 17 April 2019

Body composition variation and impact of low skeletal muscle mass in patients with advanced medullary thyroid carcinoma treated with vandetanib: results from a placebo-controlled study

scientific article published on 29 March 2013

Busulfan after HSCT in children and young adults

scientific article published on 01 March 2017

Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array

scientific article published on 24 December 2013

Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array

scientific article published on 3 July 2013

Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase-mutated intrahepatic cholangiocarcinomas

scientific article published on 20 December 2017

Comparative transplacental transfer of taxanes using the human perfused cotyledon placental model

scientific article published on 08 October 2012

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

scientific article published on 02 April 2019

Dyslipidemia causes overestimation of plasma mitotane measurements

scientific article published on 10 June 2016

Efficacy and safety of gefitinib during pregnancy: case report and literature review.

scientific article published on 16 June 2014

First case report of intrathecal panitumumab for treatment of meningeal carcinomatousis in an EGFR mutant lung adenocarcinoma patient

scientific article

Identification of soluble candidate biomarkers of therapeutic response to sunitinib in medullary thyroid carcinoma in preclinical models

scientific article published on 15 February 2011

Individualized Pazopanib Dosing-Letter

scientific article published on 01 December 2016

Influence of the multidrug transporter P-glycoprotein on the intracellular pharmacokinetics of vandetanib.

scientific article published on 28 February 2013

Insights into significance of combined inhibition of MEK and m-TOR signalling output in KRAS mutant non-small-cell lung cancer

scientific article published on 21 July 2016

Lipoprotein-Free Mitotane Exerts High Cytotoxic Activity in Adrenocortical Carcinoma.

scientific article published on 29 June 2015

Mutational profiling of isolated myeloid sarcomas and utility of serum 2HG as biomarker of IDH1/2 mutations

scientific article published on 26 February 2018

Organoids as preclinical models to improve intraperitoneal chemotherapy effectiveness for colorectal cancer patients with peritoneal metastases: Preclinical models to improve HIPEC.

scientific article published on 10 August 2017

Pharmacokinetic Behavior and Appraisal of Intravenous Busulfan Dosing in Infants and Older Children

Quantitation of isocitrate dehydrogenase (IDH)-induced D and L enantiomers of 2-hydroxyglutaric acid in biological fluids by a fully validated liquid tandem mass spectrometry method, suitable for clinical applications

scientific article published on 23 April 2016

Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon.

scientific article

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

scientific article published on 12 December 2016

Therapeutic Drug Monitoring of Carboplatin in High-Dose Protocol (TI-CE) for Advanced Germ Cell Tumors: Pharmacokinetic Results of a Phase II Multicenter Study

scientific article

Tyrosine kinase inhibitors and pregnancy: A risk to the fetus?

scientific article

Variation in transplacental transfer of tyrosine kinase inhibitors in the human perfused cotyledon model

scientific article published on 7 April 2015

What sample preparation should be chosen for targeted MS monoclonal antibody quantification in human serum?

scientific article published on 17 May 2018

[Renal toxicity of high-dose methotrexate]

scientific article published on 01 April 2018

List of works by Sophie Broutin

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

Aggressive inherited and sporadic medullary thyroid carcinomas display similar oncogenic pathways.

Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Body composition variation and impact of low skeletal muscle mass in patients with advanced medullary thyroid carcinoma treated with vandetanib: results from a placebo-controlled study

Busulfan after HSCT in children and young adults

Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array

Changes in signaling pathways induced by vandetanib in a human medullary thyroid carcinoma model, as analyzed by reverse phase protein array

Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase-mutated intrahepatic cholangiocarcinomas

Comparative transplacental transfer of taxanes using the human perfused cotyledon placental model

Crizotinib-induced immunogenic cell death in non-small cell lung cancer

Dyslipidemia causes overestimation of plasma mitotane measurements

Efficacy and safety of gefitinib during pregnancy: case report and literature review.

First case report of intrathecal panitumumab for treatment of meningeal carcinomatousis in an EGFR mutant lung adenocarcinoma patient

Identification of soluble candidate biomarkers of therapeutic response to sunitinib in medullary thyroid carcinoma in preclinical models

Individualized Pazopanib Dosing-Letter

Influence of the multidrug transporter P-glycoprotein on the intracellular pharmacokinetics of vandetanib.

Insights into significance of combined inhibition of MEK and m-TOR signalling output in KRAS mutant non-small-cell lung cancer

Lipoprotein-Free Mitotane Exerts High Cytotoxic Activity in Adrenocortical Carcinoma.

Mutational profiling of isolated myeloid sarcomas and utility of serum 2HG as biomarker of IDH1/2 mutations

Organoids as preclinical models to improve intraperitoneal chemotherapy effectiveness for colorectal cancer patients with peritoneal metastases: Preclinical models to improve HIPEC.

Pharmacokinetic Behavior and Appraisal of Intravenous Busulfan Dosing in Infants and Older Children

Quantitation of isocitrate dehydrogenase (IDH)-induced D and L enantiomers of 2-hydroxyglutaric acid in biological fluids by a fully validated liquid tandem mass spectrometry method, suitable for clinical applications

Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon.

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

Therapeutic Drug Monitoring of Carboplatin in High-Dose Protocol (TI-CE) for Advanced Germ Cell Tumors: Pharmacokinetic Results of a Phase II Multicenter Study

Tyrosine kinase inhibitors and pregnancy: A risk to the fetus?

Variation in transplacental transfer of tyrosine kinase inhibitors in the human perfused cotyledon model

What sample preparation should be chosen for targeted MS monoclonal antibody quantification in human serum?

[Renal toxicity of high-dose methotrexate]