List of works - Finian J. Leeper

(E,E)-1,5-Cyclooctadiene: a small and fast click-chemistry multitalent

scientific article (publication date: 2011)

A fragment-based approach to identifying ligands for riboswitches

scientific article

Anticancer and immunosuppressive properties of bacterial prodiginines

scientific article

Asymmetric Stetter reactions catalyzed by thiamine diphosphate-dependent enzymes

scientific article published on 24 June 2014

Bacterial biosynthetic gene clusters encoding the anti-cancer haterumalide class of molecules: biogenesis of the broad spectrum antifungal and anti-oomycete compound, oocydin A.

scientific article published on 24 September 2012

Biomimetic Syntheses of Phenols from Polyketones ⬇️

scientific article published on January 1, 1978

Biosynthesis of porphyrins and related macrocycles, Part 43. Isolation and characterization of intermediates of coenzyme B12 biosynthesis, a cobyrinic acid triamide, the a,c-diamide and their Co-(5'-deoxy-5'-adenosyl) derivatives, from Propionibacte

scientific article published on 01 August 1995

Biosynthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro-intermediate for porphyrin biosynthesis: inhibition of cosynthetase

Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq.

scientific article published on 6 March 2015

Biosynthesis of the polyether antibiotic ICI139603 in Streptomyces longisporoflavus: investigation of deuterium retention after incorporation of CD3 13CO2H, 13CD3CO2H, and CH3CD2 13CO2H using 2H n.m.r. and edited 13C n.m.r. spectra

Biosynthesis of the polyketide antibiotic ICI139603 in Streptomyces longisporoflavus: assignment of the 13C n.m.r. spectrum by two-dimensional methods, and determination of the origin of the carbon atoms

Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomy ⬇️

scientific article published in May 2005

Chemoenzymatic synthesis of prodigiosin analogues--exploring the substrate specificity of PigC.

scientific article published on 5 February 2008

Crystallographic snapshots of oxalyl-CoA decarboxylase give insights into catalysis by nonoxidative ThDP-dependent decarboxylases

scientific article

Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells.

scientific article published on May 2011

Disruption of the copper efflux pump (CopA) of Serratia marcescens ATCC 274 pleiotropically affects copper sensitivity and production of the tripyrrole secondary metabolite, prodigiosin.

scientific article published on 27 September 2005

Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics

scientific article published on 4 July 2016

Dual-sugar imaging using isonitrile and azido-based click chemistries

scientific article published on November 2013

Editorial: Vitamins and cofactors—chemistry, biochemistry and biology

scientific article published on 12 September 2007

Exploring isonitrile-based click chemistry for ligation with biomolecules.

scientific article

Fragment screening against the thiamine pyrophosphate riboswitchthiM

Gold(I)-catalysed synthesis of a furan analogue of thiamine pyrophosphate.

scientific article published on 5 November 2014

Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches

scientific article

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging

scientific article published on 3 December 2015

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

scientific article

Imaging sialylated tumor cell glycans in vivo.

scientific article published on 14 April 2011

In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

scientific article published on 8 February 2011

Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics

scientific article published on 08 December 2006

Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue

scientific article published on August 1984

Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase

scientific article

Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues.

scientific article

Snapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme Complex

scientific article

Specificity and promiscuity at the branch point in gentamicin biosynthesis

scientific article published on 17 April 2014

Stereochemistry and mechanism of the conversion of 5-aminolaevulinic acid into porphobilinogen catalysed by porphobilinogen synthase.

scientific article published in May 2003

Structure of the Fundamental Lipopeptide Surfactin at the Air/Water Interface Investigated by Sum Frequency Generation Spectroscopy

scientific article published on 24 April 2017

Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction

scientific article

Substrate Flexibility of the Flavin-Dependent Dihydropyrrole Oxidases PigB and HapB Involved in Antibiotic Prodigiosin Biosynthesis

scientific article published on 21 October 2019

Synthesis and biological evaluation of pyrophosphate mimics of thiamine pyrophosphate based on a triazole scaffold.

scientific article

The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation

scientific article published on November 2004

The biosynthesis of porphyrins, chlorophylls, and vitamin B12

scientific article (publication date: 1985)

The evidence for a spirocyclic intermediate in the formation of uroporphyrinogen III by cosynthase

scientific article published on 01 January 1994

The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis.

scientific article published on August 1997

Thiamin diphosphate in biological chemistry: analogues of thiamin diphosphate in studies of enzymes and riboswitches.

scientific article published on 23 April 2009

Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.

scientific article

α-Hydroxy-β-keto acid rearrangement-decarboxylation: impact on thiamine diphosphate-dependent enzymatic transformations.

scientific article

List of works by Finian J. Leeper

(E,E)-1,5-Cyclooctadiene: a small and fast click-chemistry multitalent

A fragment-based approach to identifying ligands for riboswitches

Anticancer and immunosuppressive properties of bacterial prodiginines

Asymmetric Stetter reactions catalyzed by thiamine diphosphate-dependent enzymes

Bacterial biosynthetic gene clusters encoding the anti-cancer haterumalide class of molecules: biogenesis of the broad spectrum antifungal and anti-oomycete compound, oocydin A.

Biomimetic Syntheses of Phenols from Polyketones ⬇️

Biosynthesis of porphyrins and related macrocycles, Part 43. Isolation and characterization of intermediates of coenzyme B12 biosynthesis, a cobyrinic acid triamide, the a,c-diamide and their Co-(5'-deoxy-5'-adenosyl) derivatives, from Propionibacte

Biosynthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro-intermediate for porphyrin biosynthesis: inhibition of cosynthetase

Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq.

Biosynthesis of the polyether antibiotic ICI139603 in Streptomyces longisporoflavus: investigation of deuterium retention after incorporation of CD3 13CO2H, 13CD3CO2H, and CH3CD2 13CO2H using 2H n.m.r. and edited 13C n.m.r. spectra

Biosynthesis of the polyketide antibiotic ICI139603 in Streptomyces longisporoflavus: assignment of the 13C n.m.r. spectrum by two-dimensional methods, and determination of the origin of the carbon atoms

Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomy ⬇️

Chemoenzymatic synthesis of prodigiosin analogues--exploring the substrate specificity of PigC.

Crystallographic snapshots of oxalyl-CoA decarboxylase give insights into catalysis by nonoxidative ThDP-dependent decarboxylases

Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells.

Disruption of the copper efflux pump (CopA) of Serratia marcescens ATCC 274 pleiotropically affects copper sensitivity and production of the tripyrrole secondary metabolite, prodigiosin.

Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics

Dual-sugar imaging using isonitrile and azido-based click chemistries

Editorial: Vitamins and cofactors—chemistry, biochemistry and biology

Exploring isonitrile-based click chemistry for ligation with biomolecules.

Fragment screening against the thiamine pyrophosphate riboswitchthiM

Gold(I)-catalysed synthesis of a furan analogue of thiamine pyrophosphate.

Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

Imaging sialylated tumor cell glycans in vivo.

In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics

Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue

Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase

Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues.

Snapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme Complex

Specificity and promiscuity at the branch point in gentamicin biosynthesis

Stereochemistry and mechanism of the conversion of 5-aminolaevulinic acid into porphobilinogen catalysed by porphobilinogen synthase.

Structure of the Fundamental Lipopeptide Surfactin at the Air/Water Interface Investigated by Sum Frequency Generation Spectroscopy

Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction

Substrate Flexibility of the Flavin-Dependent Dihydropyrrole Oxidases PigB and HapB Involved in Antibiotic Prodigiosin Biosynthesis

Synthesis and biological evaluation of pyrophosphate mimics of thiamine pyrophosphate based on a triazole scaffold.

The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation

The biosynthesis of porphyrins, chlorophylls, and vitamin B12

The evidence for a spirocyclic intermediate in the formation of uroporphyrinogen III by cosynthase

The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis.

Thiamin diphosphate in biological chemistry: analogues of thiamin diphosphate in studies of enzymes and riboswitches.

Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.

α-Hydroxy-β-keto acid rearrangement-decarboxylation: impact on thiamine diphosphate-dependent enzymatic transformations.