List of works - John R Horton

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

scientific article

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

scientific article

Amyloid-like assembly of the low complexity domain of yeast Nab3.

scientific article

Asp34 of PvuII endonuclease is directly involved in DNA minor groove recognition and indirectly involved in catalysis

scientific article

Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase

scientific article published on 23 July 2004

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

scientific article published on 8 December 2015

Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix

scientific article published on 08 June 2021

Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.

scientific article published on 25 August 2011

Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell-cycle control of DNA synthesis

scientific article

DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins

scientific article published on 15 March 2018

DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase

scientific article

DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion

scientific article

Detecting and interpreting DNA methylation marks

scientific article published on 19 July 2018

Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain.

scientific article published on 2 May 2008

Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor ⬇️

scientific article

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

scientific article published on 27 September 2021

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

scientific article

How is modification of the DNA substrate recognized by the PvuII restriction endonuclease?

scientific article

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

scientific article published on 14 March 2018

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a

scientific article

Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta

scientific article

Modification-dependent restriction endonuclease, MspJI, flips 5-methylcytosine out of the DNA helix

scientific article

Multiwavelength anomalous diffraction as a direct phasing vehicle in macromolecular crystallography

scientific article published on January 1989

Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity

scientific article published on 25 February 2015

PvuII endonuclease contains two calcium ions in active sites

scientific article published in July 2000

Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression

scientific article

Reply to Röglin et al.: Synchrotron radiation-induced covalent modification of 14-3-3ζ by diazene compounds containing pyridoxal phosphate.

scientific article published in May 2012

Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites

scientific article published on 27 December 2017

STRUCTURAL AND FUNCTIONAL CONSEQUENCES OF CIRCULAR PERMUTATION ON THE ACTIVE SITE OF OLD YELLOW ENZYME

scientific article

Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure

scientific article (publication date: May 1990)

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds

scientific article published on 13 July 2016

Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

scientific article published on 15 May 2017

Structural Redesign of Lipase B from Candida antarctica by Circular Permutation and Incremental Truncation

scientific article

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

scientific article

Structural basis for human PHF2 Jumonji domain interaction with metal ions

scientific article

Structural basis for human PRDM9 action at recombination hot spots.

scientific article published on February 2016

Structural basis for inhibition of histamine N-methyltransferase by diverse drugs

scientific article

Structural basis for the product specificity of histone lysine methyltransferases

scientific article

Structural basis for the target specificity of actin histidine methyltransferase SETD3

scientific article published on 06 August 2019

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling

scientific article

Structural basis of allele variation of human thiopurine-S-methyltransferase

scientific article

Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease

scientific article

Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI

scientific article

Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase

scientific article published on 28 February 2006

Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA

scientific article

Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI.

scientific article

Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase

scientific article

Structure of the SANT domain from the Xenopus chromatin remodeling factor ISWI

scientific article

Structure of the bacteriophage T4 DNA adenine methyltransferase

scientific article

Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase

scientific article published on 29 July 2004

Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: potential implications for methylation-independent transcriptional repression.

scientific article published on 6 April 2015

Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base

scientific article

Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases

scientific article

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

scientific article

The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding

scientific article

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules

scientific article

The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site

scientific article published on 10 October 2019

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin

scientific article

Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase.

scientific article

Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle

scientific article

Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons

scientific article

UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications

scientific article

List of works by John R Horton

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

Amyloid-like assembly of the low complexity domain of yeast Nab3.

Asp34 of PvuII endonuclease is directly involved in DNA minor groove recognition and indirectly involved in catalysis

Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix

Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.

Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell-cycle control of DNA synthesis

DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins

DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase

DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion

Detecting and interpreting DNA methylation marks

Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain.

Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor ⬇️

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

How is modification of the DNA substrate recognized by the PvuII restriction endonuclease?

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a

Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta

Modification-dependent restriction endonuclease, MspJI, flips 5-methylcytosine out of the DNA helix

Multiwavelength anomalous diffraction as a direct phasing vehicle in macromolecular crystallography

Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity

PvuII endonuclease contains two calcium ions in active sites

Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression

Reply to Röglin et al.: Synchrotron radiation-induced covalent modification of 14-3-3ζ by diazene compounds containing pyridoxal phosphate.

Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites

STRUCTURAL AND FUNCTIONAL CONSEQUENCES OF CIRCULAR PERMUTATION ON THE ACTIVE SITE OF OLD YELLOW ENZYME

Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds

Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Structural Redesign of Lipase B from Candida antarctica by Circular Permutation and Incremental Truncation

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

Structural basis for human PHF2 Jumonji domain interaction with metal ions

Structural basis for human PRDM9 action at recombination hot spots.

Structural basis for inhibition of histamine N-methyltransferase by diverse drugs

Structural basis for the product specificity of histone lysine methyltransferases

Structural basis for the target specificity of actin histidine methyltransferase SETD3

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling

Structural basis of allele variation of human thiopurine-S-methyltransferase

Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease

Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI

Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase

Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA

Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI.

Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase

Structure of the SANT domain from the Xenopus chromatin remodeling factor ISWI

Structure of the bacteriophage T4 DNA adenine methyltransferase

Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase

Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: potential implications for methylation-independent transcriptional repression.

Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base

Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules

The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin

Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase.

Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle

Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons

UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications