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List of works by Maria Flavia Di Renzo

A cancer-predisposing "hot spot" mutation of the fumarase gene creates a dominant negative protein.

scientific article published in February 2008

A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by Luciferase imaging

scientific article

A positive feedback loop between hepatocyte growth factor receptor and β-catenin sustains colorectal cancer cell invasive growth

scientific article published on 04 September 2006

AKT activation drives the nuclear localization of CSE1L and a pro-oncogenic transcriptional activation in ovarian cancer cells.

scientific article published on 13 August 2013

Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas

scientific article

Amplification of repeat-containing transcribed sequences (ARTS): a transcriptome fingerprinting strategy to detect functionally relevant microsatellite mutations in cancer

scientific article

CD99 drives terminal differentiation of osteosarcoma cells by acting as a spatial regulator of ERK 1/2.

scientific article

Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling.

scientific article published on August 2007

Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism

scientific article published on 29 May 2012

Characterization of T lymphocytes mediating in vivo protection against RSV-induced murine sarcomas

scientific article published on 01 June 1983

Characterization of stable spontaneous metastatic variant lines of RSV-transformed mouse fibroblasts.

scientific article published on December 1982

Control of invasive growth by the HGF receptor family ⬇️

scientific article published on November 1, 1997

Daily administration of low molecular weight heparin increases Hepatocyte Growth Factor serum levels in gynaecological patients: pharmacokinetic parameters and clinical implications

scientific article

Deletion in a (T)8 microsatellite abrogates expression regulation by 3'-UTR.

scientific article

Detection of MET oncogene/hepatocyte growth factor receptor in lymph node metastases from head and neck squamous cell carcinomas.

scientific article

ERalpha as ligand-independent activator of CDH-1 regulates determination and maintenance of epithelial morphology in breast cancer cells

scholarly article

Expression of Hepatocyte Growth Factor (HGF) and its Receptor (MET) in Medullary Carcinoma of the Thyroid

scientific article published on 01 January 2000

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis

scientific article published on 26 October 2010

Feline STK gene expression in mammary carcinomas

scientific article published on March 2002

Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis.

scientific article published on 30 March 2010

Genes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatin

article

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

article

HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor.

scientific article

Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF.

scientific article

Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy.

scientific article

Hepatocyte growth factor installs a survival platform for colorectal cancer cell invasive growth and overcomes p38 MAPK-mediated apoptosis

scientific article published on 3 May 2006

IRF-1 expression is induced by cisplatin in ovarian cancer cells and limits drug effectiveness

scientific article

Immunofluorescence localization of phosphotyrosine containing proteins in RSV-transformed mouse fibroblasts.

scientific article published on September 1984

Lipid characteristics of RSV-transformed Balb/c 3T3 cell lines with different spontaneous metastatic potentials.

scientific article published on August 1989

MET overexpression turns human primary osteoblasts into osteosarcomas.

scientific article published on May 2006

MET receptor is overexpressed but not mutated in oral squamous cell carcinomas.

scientific article published in December 2001

Metastatic clones selected from an RSV-induced mouse sarcoma share a common marker chromosome.

scientific article published on April 1983

Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

scientific article

Monoclonal Antibodies to the Collagen Binding Domain of Human Plasma Fibronectin

scientific article published on 01 January 1984

Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion.

scientific article published in December 2002

Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas.

scientific article

Overexpression of the Met/HGF receptor in ovarian cancer.

scientific article published in September 1994

Overexpression of the c-MET/HGF receptor in human thyroid carcinomas derived from the follicular epithelium.

scientific article published in February 1995

PIM2 kinase is induced by cisplatin in ovarian cancer cells and limits drug efficacy

scientific article

Patient-Derived Cancer Models

scientific article published on 15 December 2020

Protein tyrosine kinases associated with human malignancies.

scientific article published on January 1987

Proteins phosphorylated on tyrosine as markers of human tumor cell lines

scientific article published on 01 April 1987

Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma ⬇️

scientific article published on April 22, 2003

Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas

scientific article published on 01 March 2000

Spontaneous feline mammary carcinoma is a model of HER2 overexpressing poor prognosis human breast cancer

scientific article published on February 2005

TOP2A gene copy gain predicts response of epithelial ovarian cancers to pegylated liposomal doxorubicin: TOP2A as marker of response to PLD in ovarian cancer.

scientific article published on 20 June 2015

The MET oncogene transforms human primary bone-derived cells into osteosarcomas by targeting committed osteo-progenitors

scientific article

The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness

scientific article (publication date: 15 August 2003)

The cellular apoptosis susceptibility CAS/CSE1L gene protects ovarian cancer cells from death by suppressing RASSF1C.

scientific article published on 2 March 2012

The integrin-linked kinase-associated phosphatase (ILKAP) is a regulatory hub of ovarian cancer cell susceptibility to platinum drugs.

scientific article

The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.

scientific article

The therapeutic potential of hepatocyte growth factor to sensitize ovarian cancer cells to cisplatin and paclitaxel in vivo

scientific article published on April 2007

Translational Research in Ovarian Cancer

scientific article published on 08 December 2020

Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression

scientific article

Xenopatients show the need for precision medicine approach to chemotherapy in ovarian cancer.

scientific article published on 24 March 2016

met oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre-clinical model of human osteosarcoma.

scientific article published on July 2009

p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line

scientific article published on August 1988

p38 MAPK downregulates phosphorylation of Bad in doxorubicin-induced endothelial apoptosis

scientific article published on 7 July 2006

p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis

scientific article published on June 2006

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