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List of works by Marcus Conrad

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

scientific article

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

scientific article published on 25 January 2016

A cozy niche in an iron world

scientific article published on 04 November 2020

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

scientific article published on 14 November 2016

ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling

scientific article published on 2 December 2011

Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity

scientific article published on March 2010

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency

scientific article published on 13 June 2017

B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance

article

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

scientific article published on 6 August 2010

Broken hearts: Iron overload, ferroptosis and cardiomyopathy

scientific article published on 01 April 2019

Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation

journal article published in 2015

Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons

scientific article published on 06 March 2014

Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice

scientific article published on 14 June 2013

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

scientific article published on 26 October 2017

Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function

scientific article published on 20 February 2015

Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.

scientific article published on 14 March 2011

Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development

scientific journal article

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

scientific article published on 7 June 2013

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

scientific article

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

scientific article published on 20 July 2021

Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase

scientific article published on 2 February 2006

Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE

scientific article published on 17 December 2018

Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium

scientific article

EpCAM is involved in maintenance of the murine embryonic stem cell phenotype

scientific article

Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice

scientific article (publication date: 2012)

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

scientific article

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

scientific article published on 18 May 2017

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

scientific article published on 28 April 2015

Ferroptosis Inhibition: Mechanisms and Opportunities

scientific article published on 28 March 2017

Ferroptosis and necroinflammation, a yet poorly explored link

scientific article published on 06 August 2018

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

scientific article published on 01 July 2019

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

scientific article

Ferroptosis: the Good, the Bad and the Ugly

scientific article published on 04 November 2020

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

scientific article

Glutathione Peroxidase 4 and Ferroptosis

Glutathione Peroxidases

Glutathione and thioredoxin dependent systems in neurodegenerative disease: what can be learned from reverse genetics in mice

scientific article published on 18 January 2013

Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

scientific article published on 30 January 2015

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

scientific article published on 26 May 2016

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

scientific article

Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.

scientific article published on 25 March 2011

Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration

scientific article

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

scientific article published on 30 December 2015

In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model

scientific article published on 03 November 2021

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

scientific article

Induction of inducible nitric oxide synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration

scientific article published on 10 May 2014

Iron and ferroptosis: A still ill-defined liaison

scientific article published on 9 March 2017

Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis

scientific article

Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation

scientific article

Lipoxygenases-Killers against Their Will?

scientific article

Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation

scientific article published on 2 November 2010

Mitochondrial Thioredoxin Reductase Is Essential for Early Postischemic Myocardial Protection

scientific article published on 05 December 2011

Mitochondrial and cytosolic thioredoxin reductase knockout mice

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

scientific article

Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion.

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Mouse Models for Glutathione Peroxidase 4 (GPx4)

Mouse Models that Target Individual Selenoproteins

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy

scientific article

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

scholarly article by Behrouz Hassannia et al published 1 August 2018 in Journal of Clinical Investigation

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

scientific journal article

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4.

scientific article published on 24 April 2018

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

scientific article published on 7 March 2017

Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate

article

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

scientific article

Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.

scientific article

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy

scientific article

Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals

scientific article

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.

scientific article published on 27 February 2013

Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages

scientific article

Publisher Correction: The chemical basis of ferroptosis

scientific article published on 01 February 2020

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe.

scientific article published on 23 March 2018

ROS, thiols and thiol-regulating systems in male gametogenesis

scientific article

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation

scientific article published on 01 August 2011

Regulated necrosis: disease relevance and therapeutic opportunities

scientific article published on 18 January 2016

Regulation of lipid peroxidation and ferroptosis in diverse species.

scientific article published in May 2018

Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin

scientific article published on 17 March 2010

Role of GPX4 in ferroptosis and its pharmacological implication

scientific article published on 13 September 2018

Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation

scientific article

Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.

scientific article

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling.

scientific article published on 30 July 2013

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.

scientific article published on 16 December 2017

Selenium and GPX4, a vital symbiosis

scientific article published on 6 March 2018

Selenium and iron, two elemental rivals in the ferroptotic death process.

scientific article

Selenoprotein Gene Nomenclature

scientific article published on 19 September 2016

System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency

scientific article published on 12 May 2010

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

scientific article

Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2.

scientific article published on 30 January 2013

Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx).

scientific article published in April 2003

The antioxidant requirement for plasma membrane repair in skeletal muscle

scientific article

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

scientific article published on 14 March 2022

The chemical basis of ferroptosis

scientific article published on 18 November 2019

The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells

scientific article published on 17 January 2018

The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization

scientific article published in April 2012

The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.

scientific article published on September 2005

The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond

scientific article published on 16 March 2011

The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes

scientific article published on 13 March 2017

The role of thioredoxin reductases in brain development

scientific article

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.

scientific article

Thiol switches in mitochondria: operation and physiological relevance

scientific article published on May 2015

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

scientific article published on 27 June 2016

Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.

scientific article published on 09 May 2009

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

scientific article

Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies

scientific article published on April 2010

hIAPP forms toxic oligomers in plasma

article

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