List of works - Rolf G Boot

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

scientific article published on 22 September 2017

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease.

scientific article published on 20 December 2016

A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases.

scientific article published on 24 October 2014

A single histidine residue modulates enzymatic activity in acidic mammalian chitinase

scientific article

Activity-based profiling of retaining β-glucosidases: a comparative study

scientific article published on 28 April 2011

Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors

scientific article published on 7 April 2011

Biochemistry of glycosphingolipid storage disorders: implications for therapeutic intervention

scientific article

Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease

scientific article

Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies

scientific article

CCL18: a urinary marker of Gaucher cell burden in Gaucher patients

scientific article published on 30 May 2006

Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts

scientific article

Characterization of glucocerebrosidase in Greek Gaucher disease patients: mutation analysis and biochemical studies

scientific article published on 01 January 1995

Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity.

scientific article

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

scientific article published on 03 July 2018

Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.

scientific article published on 09 October 2008

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

scientific article

Clinical evaluation of chemokine and enzymatic biomarkers of Gaucher disease

scientific article published on 01 September 2005

Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages

scientific journal article

Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates

scientific article

Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes"

scientific article published on 18 May 2017

Crystal structures of allosamidin derivatives in complex with human macrophage chitinase

scientific article (publication date: 30 May 2003)

Curdlan-mediated regulation of human phagocyte-specific chitotriosidase.

scientific article published on 10 June 2010

Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates

scientific article published on 18 July 2014

Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

scientific article

Detection of chitinase activity by 2-aminobenzoic acid labeling of chito-oligosaccharides.

scientific article

Development of an acid ceramidase activity-based probe

scientific article published on 01 April 2015

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein

scientific article

Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease.

scientific article

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation

scientific article published on January 2010

Elevated globotriaosylsphingosine is a hallmark of Fabry disease.

scholarly article

Elevated plasma chemokine CCL18/PARC in beta-thalassemia.

scientific article published on 31 August 2005

Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response

scientific article published on 25 August 2011

Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

scientific article

Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement.

scientific article published on 7 July 2016

Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases.

scientific article published on 24 August 2007

Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors

scientific article published on 26 August 2014

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

scientific article published on 04 March 2019

Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages

scientific article published in September 2004

Gaucher disease and Fabry disease: new markers and insights in pathophysiology for two distinct glycosphingolipidoses

scientific article

Gaucher disease: a model disorder for biomarker discovery

scientific article published on August 2009

Glucocerebrosidase genotype of Gaucher patients in The Netherlands: limitations in prognostic value

scientific article published on 01 January 1997

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

scientific article published on 2 January 2016

Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages ⬇️

scientific article published on 24 December 2018

Glycosphingolipids and insulin resistance

scientific article published on January 2011

Glycosphingolipids--nature, function, and pharmacological modulation.

scientific article published on January 2009

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

scientific article

Human acidic mammalian chitinase erroneously known as eosinophil chemotactic cytokine is not the ortholog of mouse YM1

scientific article published on 01 August 2005

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions

scientific article published on 23 December 2020

Hydrophobic Interactions Contribute to Conformational Stabilization of Endoglycoceramidase II by Mechanism-Based Probes.

scientific article

Identification of a novel acidic mammalian chitinase distinct from chitotriosidase

scientific article

Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars

scientific article

Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2

scientific article

Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem.

scientific article published on 8 July 2016

In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases.

scientific article published on 9 February 2015

Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease

scientific article published on 15 September 2015

Increased plasma macrophage inflammatory protein (MIP)-1alpha and MIP-1beta levels in type 1 Gaucher disease

scientific article published on 14 April 2007

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

scientific article

Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases

scientific article published on 03 March 2016

Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors

scientific article published on 30 June 2020

Marked differences in tissue-specific expression of chitinases in mouse and man

scientific article published on 27 May 2005

Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention

scientific article published on 11 September 2003

Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard

scientific article published on 17 January 2015

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

scientific article

Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis.

scientific article

N-azidoacetylmannosamine-mediated chemical tagging of gangliosides

scientific article published on 27 March 2007

Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.

scientific article

Pharmacological small molecules for the treatment of lysosomal storage disorders.

scientific article published on 13 October 2010

Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis

scientific article

Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis

scientific article published on 04 October 2009

Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease

scientific article published on 01 January 2005

Potent and Selective Activity-Based Probes for GH27 Human Retaining α-Galactosidases

scientific article published on 11 August 2014

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

scientific article (publication date: 2015)

Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice

scientific article

Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish

scientific article published on 27 September 2019

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.

scientific article published in January 2005

Stabilization of Glucocerebrosidase by Active Site Occupancy.

scientific article published on 9 May 2017

Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins

scientific article

Substrate reduction therapy of glycosphingolipid storage disorders.

scientific article published on April 2006

Synthesis of l-altro-1-Deoxynojirimycin, d-allo-1-Deoxynojirimycin, and d-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin ⬇️

scientific article published on September 3, 2010

TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase

scientific article published on 30 October 2007

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1

scientific article published on 02 October 2019

The biology of the Gaucher cell: the cradle of human chitinases.

scientific article published on January 2006

The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma

scientific article

The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation

scientific article

The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.

scientific article

The human chitotriosidase gene. Nature of inherited enzyme deficiency

scientific article

Transglycosidase activity of chitotriosidase: improved enzymatic assay for the human macrophage chitinase.

scientific article published on 30 July 2003

Ultrasensitive in situ visualization of active glucocerebrosidase molecules

scientific article published on 31 October 2010

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

scientific article

Xylose-Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase

scientific article published on 13 September 2021

List of works by Rolf G Boot

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease.

A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases.

A single histidine residue modulates enzymatic activity in acidic mammalian chitinase

Activity-based profiling of retaining β-glucosidases: a comparative study

Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors

Biochemistry of glycosphingolipid storage disorders: implications for therapeutic intervention

Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease

Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies

CCL18: a urinary marker of Gaucher cell burden in Gaucher patients

Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts

Characterization of glucocerebrosidase in Greek Gaucher disease patients: mutation analysis and biochemical studies

Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity.

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

Clinical evaluation of chemokine and enzymatic biomarkers of Gaucher disease

Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages

Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates

Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes"

Crystal structures of allosamidin derivatives in complex with human macrophage chitinase

Curdlan-mediated regulation of human phagocyte-specific chitotriosidase.

Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates

Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

Detection of chitinase activity by 2-aminobenzoic acid labeling of chito-oligosaccharides.

Development of an acid ceramidase activity-based probe

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein

Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease.

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation

Elevated globotriaosylsphingosine is a hallmark of Fabry disease.

Elevated plasma chemokine CCL18/PARC in beta-thalassemia.

Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response

Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement.

Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases.

Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages

Gaucher disease and Fabry disease: new markers and insights in pathophysiology for two distinct glycosphingolipidoses

Gaucher disease: a model disorder for biomarker discovery

Glucocerebrosidase genotype of Gaucher patients in The Netherlands: limitations in prognostic value

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages ⬇️

Glycosphingolipids and insulin resistance

Glycosphingolipids--nature, function, and pharmacological modulation.

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

Human acidic mammalian chitinase erroneously known as eosinophil chemotactic cytokine is not the ortholog of mouse YM1

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions

Hydrophobic Interactions Contribute to Conformational Stabilization of Endoglycoceramidase II by Mechanism-Based Probes.

Identification of a novel acidic mammalian chitinase distinct from chitotriosidase

Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars

Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2

Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem.

In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases.

Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease

Increased plasma macrophage inflammatory protein (MIP)-1alpha and MIP-1beta levels in type 1 Gaucher disease

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases

Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors

Marked differences in tissue-specific expression of chitinases in mouse and man

Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention

Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis.

N-azidoacetylmannosamine-mediated chemical tagging of gangliosides

Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.

Pharmacological small molecules for the treatment of lysosomal storage disorders.

Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis

Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis

Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease

Potent and Selective Activity-Based Probes for GH27 Human Retaining α-Galactosidases

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice

Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.

Stabilization of Glucocerebrosidase by Active Site Occupancy.

Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins

Substrate reduction therapy of glycosphingolipid storage disorders.

Synthesis of l-altro-1-Deoxynojirimycin, d-allo-1-Deoxynojirimycin, and d-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin ⬇️