List of works - Vincenzo Calderone

(+/-)-Naringenin as large conductance Ca(2+)-activated K+ (BKCa) channel opener in vascular smooth muscle cells

scientific article published on 6 November 2006

1,2,3-Triazol-carboxanilides and 1,2,3-triazol-(N-benzyl)-carboxamides as BK-potassium channel activators. XII.

scientific article published on 7 March 2008

1,4- and 2,4-substituted-1,2,3-triazoles as potential potassium channel activators. VII.

scientific article

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions

scientific article published on 28 May 2013

1,5-Diarylsubstituted 1,2,3-triazoles as potassium channel activators. VI.

scientific article

5-(4′-Substituted-2′-nitroanilino)-1,2,3-triazoles as new potential potassium channel activators. I

scientific article published on 01 July 2000

A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis

scientific article published on 27 May 2016

A modified aortic multiple-ring preparation for functional studies

scientific article published on 01 June 1996

A simplified empirical approach to evaluate the dissociation constant of a full agonist by the irreversible receptor inactivation method.

scientific article published in July 1998

An alternative method to evaluate the nature of an antagonist and its potency: a theoretical approach.

scientific article published in April 1998

An update on hybrid drugs in cardiovascular drug research

scientific article published on December 2008

Anti-ischaemic activity of an antioxidant aldose reductase inhibitor on diabetic and non-diabetic rat hearts

scientific article published on January 2010

Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel

scientific article

Antioxidant and Antisenescence Effects of Bergamot Juice

scientific article published in 2018

Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

scientific article

Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII.

scientific article published on 3 March 2005

Cardioprotective effects of different flavonoids against myocardial ischaemia/reperfusion injury in Langendorff-perfused rat hearts

scientific article published on 26 February 2013

Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies

scientific article published in June 2002

Conformationally restrained analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2',5'-morpholines].

scientific article published in January 2002

Correction to Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors

Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia.

scientific article published on 12 October 2015

D-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase

scientific article published on 18 February 2016

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

scientific article published on 22 October 2015

Different patterns of H2S/NO activity and cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions

scientific article

Different patterns of H2S/NO cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions

Differential effects of fondaparinux and bemiparin on angiogenic and vasculogenesis-like processes

scientific article published on 11 April 2012

Drug-induced block of cardiac HERG potassium channels and development of torsade de pointes arrhythmias: the case of antipsychotics

scientific article

Editorial [Hot Topic: Potassium Channels (Guest Editor: Dr. Vincenzo Calderone)]

Effects of KATPopeners on the QT prolongation induced by HERG-blocking drugs in guinea-pigs

Efficacy of isothiocyanate-based compounds on different forms of persistent pain

Enantioselectivity in Cardioprotection induced by (S)- (−)-2,2-Dimethyl-N-(4′-acetamido-benzyl)-4-spiromorpholone-chromane

scientific article published on 01 March 2009

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

scientific article published on 18 December 2013

Eruca sativa Mill. seed extract promotes anti-obesity and hypoglycemic effects in mice fed with a high-fat diet

scientific article published on 03 November 2020

Erucin exhibits vasorelaxing effects and antihypertensive activity by H2 S-releasing properties

scientific article published on 15 April 2019

Evaluation of the NO-releasing properties of NO-donor linkers

scientific article published in February 2008

Experimental and theoretical comparisons between the classical Schild analysis and a new alternative method to evaluate the p A 2 of competitive antagonists

scientific article published on 01 November 1999

Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection.

scientific article published on 29 December 2015

Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels

scientific article published on 04 January 2007

Heterocyclic analogs of benzanilide derivatives as potassium channel activators. IX.

scientific article published on 19 April 2006

Highly Potent 1,4-Benzo-thiazine Derivatives as KATP-Channel Openers

Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers

scientific article published in August 2003

Hormonal influence on the release of endothelial nitric oxide: gender-related dimorphic sensitivity of rat aorta for noradrenaline

scientific article

Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.

scientific article

Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation

scientific article published on August 2015

Hydrogen sulfide releasing capacity of natural isothiocyanates: is it a reliable explanation for the multiple biological effects of Brassicaceae?

scientific article published on 25 June 2014

Hydrogen sulphide: novel opportunity for drug discovery

scientific article published on 07 December 2010

Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme

scientific article published on 18 October 2012

In vivo adenosine A2B receptor desensitization in guinea-pig airway smooth muscle: Implications for asthma

scientific article published on 01 August 2007

Influence of depolarization on vasorelaxant potency and efficacy of Ca2+ entry blockers, K+ channel openers, nitrate derivatives, salbutamol and papaverine in rat aortic rings

scientific article published on 01 October 1998

Inhibitors of the renal outer medullary potassium channel: a patent review

scientific article published on 25 May 2015

Intrinsic activity and EC50: the simplest tools for the evaluation of the dissociation constant of a partial agonist

scientific article published on 01 November 1998

Isothiocyanates and inhibition of mast cell degranulation: Is hydrogen sulfide the real player?

article published in 2015

Large conductance Ca(2+)-activated K(+) channel (BKCa) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects.

scientific article published on 14 May 2013

Mitochondrial potassium channels as pharmacological target for cardioprotective drugs.

scientific article

Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor

scientific article published in May 2005

N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors

scientific article published on 24 October 2007

NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs.

scientific article published on 27 June 2009

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs

scientific article published in November 2004

NSAID-induced enteropathy: are the currently available selective COX-2 inhibitors all the same?

scientific article

Natural modulators of large-conductance calcium-activated potassium channels

scientific article published on October 2003

New 5-substituted-1-(2-hydroxybenzoyl)-benzotriazoles, potassium channel activators. IV.

scientific article published in November 2001

New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties

scientific article published on 01 December 2006

New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design, Synthesis, and Biopharmacological Properties

scientific article published on 01 April 2006

New amido derivatives as potential BKCa potassium channel activators. XI

scientific article published on 05 July 2007

New emerging prospects in the pharmacotherapy of hypertension.

scientific article published on January 2008

Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers

scientific article

Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands

scientific article

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors

scientific article published on 11 April 2013

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

scientific article published on 31 October 2011

Off-target ACE2 ligands: possible therapeutic option for CoVid-19?

scientific article published on 02 May 2020

Pharmacodynamic hybrids coupling established cardiovascular mechanisms of action with additional nitric oxide releasing properties

scientific article published on January 2009

Pharmacological characterization of the vascular effects of aryl isothiocyanates: is hydrogen sulfide the real player?

scientific article published on 25 November 2013

Pharmacological modulation of the hydrogen sulfide (H2 S) system by dietary H2 S-donors: A novel promising strategy in the prevention and treatment of type 2 diabetes mellitus

scientific article published on 29 October 2020

Prediction of hERG potassium channel affinity by the CODESSA approach

scientific article published on 19 January 2006

Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers

scientific article

Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists: Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

article

Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle

scientific article published on 27 June 2013

QSAR studies on BK channel activators.

scientific article published on 5 November 2008

QT prolongation in anaesthetized guinea-pigs: an experimental approach for preliminary screening of torsadogenicity of drugs and drug candidates.

scientific article

Quantitative structure-activity relationship models for predicting biological properties, developed by combining structure- and ligand-based approaches: an application to the human ether-a-go-go-related gene potassium channel inhibition.

scientific article published in October 2009

R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptors

scientific article

Some structural changes on triazolyl-benzotriazoles and triazolyl-benzimidazolones as potential potassium channel activators. III.

scientific article published in November 2001

Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel

scientific article

Structural modifications of benzanilide derivatives, effective potassium channel openers. X

Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine: identification of beta 3-antagonists

scientific article published in November 2003

Synthesis and biological activity of novel substituted benzanilides as potassium channel activators. V.

scientific article

Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors

scientific article published in April 2004

Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia

scientific article published on 13 January 2011

Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X.

scientific article published in November 2001

Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications

scientific article published on 26 December 2014

Synthesis and α-adrenergic and I1-imidazoline activity of 3-phenylpiperidines dimethyl-substituted on the phenyl ring

Synthesis and β-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine:potential antihypertensive agents – Part IX

scientific article published on 01 September 2000

Synthesis of 1,8-naphthyridine derivatives: Potential antihypertensive agents — Part VII

Synthesis of 1,8-naphthyridine derivatives: potential antihypertensive agents – Part VIII

Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties

scientific article published on 2 August 2010

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage.

scientific article published on 12 March 2017

The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1

scientific article published on 25 January 2020

The activation of mitochondrial BK potassium channels contributes to the protective effects of naringenin against myocardial ischemia/reperfusion injury.

scientific article

The novel H2 S donor 4-carboxy-phenyl isothiocyanate inhibits mast cell degranulation and renin release by decreasing intracellular calcium.

scientific article published on 22 August 2016

The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress

scientific article published on 8 September 2016

The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and end

scientific article

The xanthones gentiacaulein and gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana

scientific article published in August 2003

Triazolyl–benzimidazolones and triazolyl–benzotriazoles: new potential potassium channel activators. II

scientific article published on 01 October 2000

Using hydrogen sulfide to design and develop drugs

scientific article

Vasodilator activity of Michelia figo Spreng. (Magnoliaceae) by in vitro functional study

scientific article published in April 2004

Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae).

scientific article published in March 2002

Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels.

scientific article

Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels

scientific article published on 17 September 2004

Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta.

scientific article published on 23 June 2016

List of works by Vincenzo Calderone

(+/-)-Naringenin as large conductance Ca(2+)-activated K+ (BKCa) channel opener in vascular smooth muscle cells

1,2,3-Triazol-carboxanilides and 1,2,3-triazol-(N-benzyl)-carboxamides as BK-potassium channel activators. XII.

1,4- and 2,4-substituted-1,2,3-triazoles as potential potassium channel activators. VII.

1,4-Benzothiazine ATP-sensitive potassium channel openers: modifications at the C-2 and C-6 positions

1,5-Diarylsubstituted 1,2,3-triazoles as potassium channel activators. VI.

5-(4′-Substituted-2′-nitroanilino)-1,2,3-triazoles as new potential potassium channel activators. I

A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis

A modified aortic multiple-ring preparation for functional studies

A simplified empirical approach to evaluate the dissociation constant of a full agonist by the irreversible receptor inactivation method.

An alternative method to evaluate the nature of an antagonist and its potency: a theoretical approach.

An update on hybrid drugs in cardiovascular drug research

Anti-ischaemic activity of an antioxidant aldose reductase inhibitor on diabetic and non-diabetic rat hearts

Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel

Antioxidant and Antisenescence Effects of Bergamot Juice

Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII.

Cardioprotective effects of different flavonoids against myocardial ischaemia/reperfusion injury in Langendorff-perfused rat hearts

Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies

Conformationally restrained analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2',5'-morpholines].

Correction to Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors

Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia.

D-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

Different patterns of H2S/NO activity and cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions

Different patterns of H2S/NO cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions

Differential effects of fondaparinux and bemiparin on angiogenic and vasculogenesis-like processes

Drug-induced block of cardiac HERG potassium channels and development of torsade de pointes arrhythmias: the case of antipsychotics

Editorial [Hot Topic: Potassium Channels (Guest Editor: Dr. Vincenzo Calderone)]

Effects of KATPopeners on the QT prolongation induced by HERG-blocking drugs in guinea-pigs

Efficacy of isothiocyanate-based compounds on different forms of persistent pain

Enantioselectivity in Cardioprotection induced by (S)- (−)-2,2-Dimethyl-N-(4′-acetamido-benzyl)-4-spiromorpholone-chromane

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

Eruca sativa Mill. seed extract promotes anti-obesity and hypoglycemic effects in mice fed with a high-fat diet

Erucin exhibits vasorelaxing effects and antihypertensive activity by H2 S-releasing properties

Evaluation of the NO-releasing properties of NO-donor linkers

Experimental and theoretical comparisons between the classical Schild analysis and a new alternative method to evaluate the p A 2 of competitive antagonists

Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection.

Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels

Heterocyclic analogs of benzanilide derivatives as potassium channel activators. IX.

Highly Potent 1,4-Benzo-thiazine Derivatives as KATP-Channel Openers

Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers

Hormonal influence on the release of endothelial nitric oxide: gender-related dimorphic sensitivity of rat aorta for noradrenaline

Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.

Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation

Hydrogen sulfide releasing capacity of natural isothiocyanates: is it a reliable explanation for the multiple biological effects of Brassicaceae?

Hydrogen sulphide: novel opportunity for drug discovery

Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme

In vivo adenosine A2B receptor desensitization in guinea-pig airway smooth muscle: Implications for asthma

Influence of depolarization on vasorelaxant potency and efficacy of Ca2+ entry blockers, K+ channel openers, nitrate derivatives, salbutamol and papaverine in rat aortic rings

Inhibitors of the renal outer medullary potassium channel: a patent review

Intrinsic activity and EC50: the simplest tools for the evaluation of the dissociation constant of a partial agonist

Isothiocyanates and inhibition of mast cell degranulation: Is hydrogen sulfide the real player?

Large conductance Ca(2+)-activated K(+) channel (BKCa) activating properties of a series of novel N-arylbenzamides: Channel subunit dependent effects.

Mitochondrial potassium channels as pharmacological target for cardioprotective drugs.

Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor

N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors

NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs.

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs

NSAID-induced enteropathy: are the currently available selective COX-2 inhibitors all the same?

Natural modulators of large-conductance calcium-activated potassium channels

New 5-substituted-1-(2-hydroxybenzoyl)-benzotriazoles, potassium channel activators. IV.

New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties

New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design, Synthesis, and Biopharmacological Properties

New amido derivatives as potential BKCa potassium channel activators. XI

New emerging prospects in the pharmacotherapy of hypertension.

Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers

Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

Off-target ACE2 ligands: possible therapeutic option for CoVid-19?

Pharmacodynamic hybrids coupling established cardiovascular mechanisms of action with additional nitric oxide releasing properties

Pharmacological characterization of the vascular effects of aryl isothiocyanates: is hydrogen sulfide the real player?

Pharmacological modulation of the hydrogen sulfide (H2 S) system by dietary H2 S-donors: A novel promising strategy in the prevention and treatment of type 2 diabetes mellitus

Prediction of hERG potassium channel affinity by the CODESSA approach

Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers

Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists: Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle

QSAR studies on BK channel activators.