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Authors whose works are in public domain in at least one jurisdiction

List of works by Lee L. Rubin

A TALEN genome-editing system for generating human stem cell-based disease models

scientific article published on 13 December 2012

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

scientific article published on 01 May 1995

A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein.

scientific article published on 15 June 2012

A comparison of non-integrating reprogramming methods

scientific article

A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma

scientific article published on 16 May 2019

A molecular defect in virally transformed muscle cells that cannot cluster acetylcholine receptors.

scientific article

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.

scientific article

A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons

scientific article

A paracrine requirement for hedgehog signalling in cancer

scientific article

A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides

scientific article published on 16 May 2023

A screen for regulators of survival of motor neuron protein levels

scientific article

A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

scientific article

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

scientific article

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog

scientific article

Accumulation of acetylcholine receptors and acetylcholinesterase at newly formed nerve-muscle synapses ⬇️

scientific article published on December 1, 1978

Accumulation of acetylcholinesterase at newly formed nerve--muscle synapases

scientific article published on March 1, 1979

Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

scientific article published on November 1997

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication

scientific journal article

Aggregated SOD1 causes selective death of cultured human motor neurons

scientific article published in Scientific Reports

Applying Deep Neural Network Analysis to High-Content Image-Based Assays

scientific article published on 08 July 2019

Assays for the identification and prioritization of drug candidates for spinal muscular atrophy

scientific article

Assessing kinetics and recruitment of DNA repair factors using high content screens

scientific article published on 01 December 2021

Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation

scientific article

Black widow spider venom: effect of purified toxin on lipid bilayer membranes

scientific article published on September 10, 1976

Blocking cytochrome c activity within intact neurons inhibits apoptosis.

scientific article published on September 1998

Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes

CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus

scientific article published on 01 October 2019

Cell adhesion, cell junctions and the blood-brain barrier

scientific article published on October 1996

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

scientific article published on 15 June 2015

Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors

scientific article published on 11 February 2004

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

scientific article

Dephosphorylation of the cadherin-associated p100/p120 proteins in response to activation of protein kinase C in epithelial cells.

scientific article published in December 1997

Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro

scientific article published in October 2003

Desensitization of acetylcholine receptors in rat myotubes is enhanced by agents that elevate intracellular cAMP

scientific article published on 01 September 1988

Discovery and preclinical development of vismodegib

scientific article published on 23 May 2014

Double mode of action of black widow spider venom on frog neuromuscular junction ⬇️

scientific article published on April 1, 1978

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.

scientific article published on 11 April 2018

Effect of concanavalin A on black widow spider venom activity at the neuromuscular junction: Implications for mechanisms of venom action ⬇️

scientific article published on March 17, 1978

Effect of cytochalasin B on neuromuscular transmission in tissue culture ⬇️

scientific article published on March 5, 1976

Endothelial cells: adhesion and tight junctions

scientific article published on October 1, 1992

Evidence that tyrosine phosphorylation may increase tight junction permeability

scientific article published on February 1995

FOS licenses early events in stem cell activation driving skeletal muscle regeneration

scientific article published on 01 January 2021

GDC-0449-a potent inhibitor of the hedgehog pathway

scientific article

Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy

scientific article published on 11 June 2013

Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy

scientific article published on 16 September 2020

Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy

scientific article

Global strategic partnerships in regenerative medicine.

scientific article published in September 2014

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity

scientific article published on August 2012

Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice

scientific article published in Scientific Reports

Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology

scientific article published on 10 June 2019

Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration

scientific article published in July 2005

Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy.

scientific article published on January 2012

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

scientific article

In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images.

scientific article

Increased surface phosphatidylserine is an early marker of neuronal apoptosis

scientific article published on 01 June 1997

Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System

scientific article

Lysophosphatidic acid increases tight junction permeability in cultured brain endothelial cells.

scientific article

MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis

scientific article published on 01 January 2019

Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells

scientific article published on 17 August 2018

Microinjection of a monoclonal antibody against a 37-kD protein (tropomyosin 2) prevents the formation of new acetylcholine receptor clusters.

scientific article

Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

scientific article published on 08 October 2021

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

scientific article published on 24 November 2014

Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway

scientific article

Morphological and biochemical changes in neurons: apoptosis versus mitosis

scientific article published on 01 September 1996

Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons.

scientific article published in March 2006

Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

scientific article

Neuronal and glial cell biology

Neuronal cell death: when, why and how ⬇️

scientific article published on January 1, 1997

Notch inhibition allows oncogene-independent generation of iPS cells

scientific article

Occludin as a possible determinant of tight junction permeability in endothelial cells ⬇️

scientific article published on July 1, 1997

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

scientific article published on 02 January 2020

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis

scientific article published on 12 May 2020

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis

scientific article published on 01 July 2020

Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

scientific article published in 2022

Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons ⬇️

scientific article published on January 15, 1998

Potent agonists of the Hedgehog signaling pathway.

scientific article

Potent inhibitors of the hedgehog signaling pathway.

scientific article published on 15 February 2008

Pro-myogenic small molecules revealed by a chemical screen on primary muscle stem cells

scientific article published on 09 October 2020

Protection against blood-brain barrier disruption in focal cerebral ischemia by the type IV phosphodiesterase inhibitor BBB022: a quantitative study.

scientific article published in March 1998

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.

scientific article published on 29 June 2017

Recovery from paralysis in adult rats using embryonic stem cells.

scientific article published on July 2006

Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro

scientific article published in Nature

Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging

scientific article

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.

scientific article

Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons

scientific article

Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons ⬇️

scientific article published on March 1, 1998

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation

scientific article

Signal transduction at the blood-brain barrier

scientific article published on August 1995

Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease.

scientific article

Single-cell transcriptomic profiling of the aging mouse brain

scientific article published on 24 September 2019

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

scientific article

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

scientific article published in September 2003

Spinal Muscular Atrophy: Huge Steps

scientific article published on 01 March 2019

Stem cell biology and drug discovery. ⬇️

scientific article

Stem cells and drug discovery: the beginning of a new era?

scientific article published on 01 February 2008

Studying human disease using human neurons.

scientific article published on 6 April 2016

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

scientific article published on 26 May 2017

Suppression of MAP4K4 Signaling Ameliorates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis-Molecular Studies Toward New Therapeutics

scientific article published on 10 July 2019

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice

scientific article published in September 2004

Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells

scientific article published on 02 September 2021

Systemic nature of spinal muscular atrophy revealed by studying insurance claims

scientific article published on 14 March 2019

Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened

scientific article

Targeting the Hedgehog pathway in cancer

scientific article published on 01 December 2006

Temporal gene expression during differentiation of human embryonic stem cells and embryoid bodies

scientific article

The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy.

scientific article published on 21 December 2016

The blood-brain barrier in and out of cell culture ⬇️

scientific article published on October 1, 1991

The cell biology of the blood-brain barrier.

scientific article

The hedgehog pathway and neurological disorders

scientific article published on January 2006

The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

scientific journal article

Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy

scientific article

Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons

scientific article published on 01 September 2021

Toward Precision Medicine for Neurological and Neuropsychiatric Disorders

scientific article published on 07 June 2018

Transformation by Rous sarcoma virus prevents acetylcholine receptor clustering on cultured chicken muscle fibers.

scientific article

Treatment with BBB022A or rolipram stabilizes the blood-brain barrier in experimental autoimmune encephalomyelitis: an additional mechanism for the therapeutic effect of type IV phosphodiesterase inhibitors.

scientific article

Two populations of AChR in rat myotubes have different degradation rates and responses to cAMP

scientific article published on 01 September 1993

Using Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration

scientific article

Using intracellular markers to identify a novel set of surface markers for live cell purification from a heterogeneous hIPSC culture.

scientific article published on 16 January 2018

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors

scientific article

Young systemic factors as a medicine for age-related neurodegenerative diseases

scientific article published on 3 February 2015

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation

scientific article

iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease

scientific article

miRNA malfunction causes spinal motor neuron disease

scientific article

p120, a p120-related protein (p100), and the cadherin/catenin complex

scientific article

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