List of works - Isao Kii

A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach

scientific article published on 01 March 2019

A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

scientific article

Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors

scientific article

Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion

scientific article published on 28 February 2019

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

scientific article

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

scientific article published on 12 March 2018

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

scientific article published on 25 July 2017

Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing.

scientific article

Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis

scientific article published on 14 June 2015

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

scientific article

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

scientific article

Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells.

scientific article published on 14 August 2017

Double click reaction: a novel method for chemical modification of biomolecules

scientific article published in April 2012

Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity.

scientific article published on 21 April 2017

Expression, purification and characterization of soluble recombinant periostin protein produced by Escherichia coli.

scientific article

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.

scientific article published on 3 August 2015

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

scientific article

Identification of cysteine residues critically involved in homodimer formation and protein expression of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system.

scientific article published in January 2006

Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors

scientific article published on 01 September 2020

Immunohistochemical localization of periostin in tooth and its surrounding tissues in mouse mandibles during development.

scientific article published in December 2004

Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion

scientific article published on 22 August 2004

Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase.

scientific article

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

scientific article

Periostin Deficiency Causes Severe and Lethal Lung Injury in Mice With Bleomycin Administration.

scientific article published on 7 June 2016

Periostin and its interacting proteins in the construction of extracellular architectures.

scientific article published on 8 September 2017

Periostin associates with Notch1 precursor to maintain Notch1 expression under a stress condition in mouse cells

scientific article

Periostin function in communication with extracellular matrices

scientific article published on 30 October 2017

Periostin is an extracellular matrix protein required for eruption of incisors in mice

scientific article published on 14 February 2006

Periostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon.

scientific article published on 28 April 2008

Periostin is required for matricellular localization of CCN3 in periodontal ligament of mice

scientific article published on 24 December 2016

Periostin promotes secretion of fibronectin from the endoplasmic reticulum

scientific article published on 25 January 2016

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice.

scientific article published on 5 September 2017

Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ.

scientific article published on 5 April 2018

Screening of novel drugs for inhibiting hepatitis E virus replication

scientific article published on 17 April 2019

Selective inhibition of the kinase DYRK1A by targeting its folding process

scientific article (publication date: 22 April 2016)

Stable knockdown of S100A4 suppresses cell migration and metastasis of osteosarcoma.

scientific article published on March 2011

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

scientific article published on 01 July 2018

The niche component periostin is produced by cancer-associated fibroblasts, supporting growth of gastric cancer through ERK activation

scientific article published on 10 January 2014

Three-Dimensional Localization of an Individual Fluorescent Molecule with Angstrom Precision.

scientific article published on 23 June 2017

[Cell-cell interaction mediated by cadherin]

scientific article published on 01 February 2004

[Function of the fasciclin I family]

scientific article published on 01 January 2006

[Periostin function in the periodontal ligament and the periosteum]

scientific article published on 01 February 2007

List of works by Isao Kii

A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach

A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors

Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing.

Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells.

Double click reaction: a novel method for chemical modification of biomolecules

Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity.

Expression, purification and characterization of soluble recombinant periostin protein produced by Escherichia coli.

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

Identification of cysteine residues critically involved in homodimer formation and protein expression of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system.

Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors

Immunohistochemical localization of periostin in tooth and its surrounding tissues in mouse mandibles during development.

Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion

Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase.

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

Periostin Deficiency Causes Severe and Lethal Lung Injury in Mice With Bleomycin Administration.

Periostin and its interacting proteins in the construction of extracellular architectures.

Periostin associates with Notch1 precursor to maintain Notch1 expression under a stress condition in mouse cells

Periostin function in communication with extracellular matrices

Periostin is an extracellular matrix protein required for eruption of incisors in mice

Periostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon.

Periostin is required for matricellular localization of CCN3 in periodontal ligament of mice

Periostin promotes secretion of fibronectin from the endoplasmic reticulum

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice.

Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ.

Screening of novel drugs for inhibiting hepatitis E virus replication

Selective inhibition of the kinase DYRK1A by targeting its folding process

Stable knockdown of S100A4 suppresses cell migration and metastasis of osteosarcoma.

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

The niche component periostin is produced by cancer-associated fibroblasts, supporting growth of gastric cancer through ERK activation

Three-Dimensional Localization of an Individual Fluorescent Molecule with Angstrom Precision.

[Cell-cell interaction mediated by cadherin]

[Function of the fasciclin I family]

[Periostin function in the periodontal ligament and the periosteum]