List of works - Eric Cascales

A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

scientific article published on 10 September 2021

A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery.

scientific article

A unique bacterial secretion machinery with multiple secretion centers

scientific article published on 26 April 2022

Activity and Crystal Structure of the Adherent-Invasive Escherichia coli Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model

scientific article published in 2023

Agrobacterium VirB10, an ATP energy sensor required for type IV secretion

scholarly article

An Agrobacterium VirB10 mutation conferring a type IV secretion system gating defect.

scientific article published on 18 March 2011

An Epigenetic Switch Involving Overlapping Fur and DNA Methylation Optimizes Expression of a Type VI Secretion Gene Cluster ⬇️

scientific article published on July 28, 2011

Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.

scientific article

Anchoring the type VI secretion system to the peptidoglycan: TssL, TagL, TagP... what else?

scientific article published on 01 November 2010

Architecture and assembly of the Type VI secretion system.

scientific article published on 26 March 2014

Biogenesis and structure of a type VI secretion baseplate

scholarly article by Yassine Cherrak et al published 15 October 2018 in Nature Microbiology

Biogenesis and structure of a type VI secretion membrane core complex

scientific article

Biogenesis, architecture, and function of bacterial type IV secretion systems

scientific article

Characterization of the Porphyromonas gingivalis Type IX Secretion Trans-envelope PorKLMNP Core Complex

scientific article published on 5 January 2017

Colicin biology

scientific article

Crystal structure and self-interaction of the type VI secretion tail-tube protein from enteroaggregative Escherichia coli.

scientific article published on 14 February 2014

Crystal structure of the VgrG1 actin cross-linking domain of the Vibrio cholerae type VI secretion system

scientific article published on 16 August 2012

DNA substrate-induced activation of the Agrobacterium VirB/VirD4 type IV secretion system.

scientific article published on 5 April 2013

Dissection of the TssB-TssC interface during type VI secretion sheath complex formation

scientific article

Domestication of a housekeeping transglycosylase for assembly of a Type VI secretion system.

scientific article published on 5 December 2016

Energetic components VirD4, VirB11 and VirB4 mediate early DNA transfer reactions required for bacterial type IV secretion.

scientific article published on December 2004

Energetics of colicin import revealed by genetic cross-complementation between the Tol and Ton systems ⬇️

scientific article published on December 1, 2012

Expression of a Yersinia pseudotuberculosis Type VI Secretion System Is Responsive to Envelope Stresses through the OmpR Transcriptional Activator

scientific article

Fusion Reporter Approaches to Monitoring Transmembrane Helix Interactions in Bacterial Membranes.

scientific article published on January 2017

H-NS Silencing of the Salmonella Pathogenicity Island 6-Encoded Type VI Secretion System Limits Salmonella enterica Serovar Typhimurium Interbacterial Killing.

scientific article

HxcQ liposecretin is self-piloted to the outer membrane by its N-terminal lipid anchor

scientific journal article

IHF is required for the transcriptional regulation of the Desulfovibrio vulgaris Hildenborough orp operons.

scientific article published on 21 January 2014

Imaging type VI secretion-mediated bacterial killing.

scientific article published on 3 January 2013

In situ and high-resolution Cryo-EM structure of the Type VI secretion membrane complex

In vivo TssA proximity labelling during type VI secretion biogenesis reveals TagA as a protein that stops and holds the sheath

scientific article published on 01 October 2018

Inhibition of type VI secretion by an anti-TssM llama nanobody

scientific article

Inside the Chamber of Secrets of the Type III Secretion System.

scientific article

Interaction of the Colicin K Bactericidal Toxin with Components of Its Import Machinery in the Periplasm of Escherichia coli ⬇️

scientific article published on September 24, 2010

Mapping the Interactions between Escherichia coli TolQ Transmembrane Segments ⬇️

scientific article published on April 1, 2011

Mapping the interactions between escherichia coli tol subunits: rotation of the TolR transmembrane helix.

scientific article

Measure of Peptidoglycan Hydrolase Activity.

scientific article published in January 2017

Meeting report: Adaptation and communication of bacterial pathogens

scientific article published on 18 February 2016

Microbiology: And Amoebophilus Invented the Machine Gun!

scientific article published in November 2017

Molecular Dissection of the Interface between the Type VI Secretion TssM Cytoplasmic Domain and the TssG Baseplate Component.

scientific article published on 3 September 2016

Movements of the TolR C-terminal domain depend on TolQR ionizable key residues and regulate activity of the Tol complex.

scientific article published on 18 April 2007

Mutational analyses define helix organization and key residues of a bacterial membrane energy-transducing complex.

scientific article published on 15 December 2006

Nooks and crannies in type VI secretion regulation.

scientific article

Pal Lipoprotein ofEscherichia coliPlays a Major Role in Outer Membrane Integrity ⬇️

scientific article published on February 1, 2002

Priming and polymerization of a bacterial contractile tail structure

scientific article

Probing Inner Membrane Protein Topology by Proteolysis.

scientific article published in January 2017

Promoter Swapping Unveils the Role of the Citrobacter rodentium CTS1 Type VI Secretion System in Interbacterial Competition ⬇️

scientific article published on October 12, 2012

Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

scientific article published on 12 January 2022

Proton motive force drives the interaction of the inner membrane TolA and outer membrane pal proteins in Escherichia coli

scientific article published on 01 November 2000

Regulation of Type VI Secretion Gene Clusters by σ 54 and Cognate Enhancer Binding Proteins ⬇️

scientific article published on March 4, 2011

Role and Recruitment of the TagL Peptidoglycan-Binding Protein during Type VI Secretion System Biogenesis

scientific article published on 22 May 2019

Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut

scientific article published on 08 August 2016

Structural Characterization and Oligomerization of the TssL Protein, a Component Shared by Bacterial Type VI and Type IVb Secretion Systems

scientific article

Structural and dynamic properties of bacterial type IV secretion systems (review).

scientific article

Structural basis for loading and inhibition of a bacterial T6SS phospholipase effector by the VgrG spike

scientific article published on 30 April 2020

Structural biology of type VI secretion systems ⬇️

scientific article published on April 19, 2012

Structure and regulation of the type VI secretion system

scientific article

Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli.

scientific article published on 04 October 2016

Structure-Function Analysis of the C-Terminal Domain of the Type VI Secretion TssB Tail Sheath Subunit

scientific article published on 6 December 2017

Structure-Function Analysis of the TssL Cytoplasmic Domain Reveals a New Interaction between the Type VI Secretion Baseplate and Membrane Complexes

scientific article published on 3 September 2016

T6SS: killing two bugs with one stone

scientific article published in 2022

The C‐tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci‐1 Type VI secretion system, is inserted by YidC ⬇️

scientific article published on March 1, 2012

The PorX Response Regulator of the Porphyromonas gingivalis PorXY Two-Component System Does Not Directly Regulate the Type IX Secretion Genes but Binds the PorL Subunit

scientific article published on 31 August 2016

The SciZ protein anchors the enteroaggregative Escherichia coli Type VI secretion system to the cell wall

scientific article published on February 2010

The Tol-Pal proteins of the Escherichia coli cell envelope: an energized system required for outer membrane integrity?

scientific article

The TolQ–TolR proteins energize TolA and share homologies with the flagellar motor proteins MotA–MotB ⬇️

scientific article published on 01 November 2001

The Type VI Secretion System in Escherichia coli and Related Species.

scientific article published on May 2016

The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization

scientific article published on 13 October 2015

The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube Assembly

scientific article published on 19 July 2018

The type VI secretion toolkit

scientific article

The versatile bacterial type IV secretion systems

scientific article

Tol-dependent macromolecule import through the Escherichia coli cell envelope requires the presence of an exposed TolA binding motif.

scientific article

Towards a Structural Comprehension of Bacterial Type VI Secretion Systems: Characterization of the TssJ-TssM Complex of an Escherichia coli Pathovar

scientific article

Towards a complete structural deciphering of Type VI secretion system

scientific article published in February 2018

Tryptophan-mediated dimerization of the TssL transmembrane anchor is required for Type VI secretion system activity.

scientific article published on 16 February 2018

TssA: The cap protein of the Type VI secretion system tail.

scientific article

TssK Is a Trimeric Cytoplasmic Protein Interacting with Components of Both Phage-like and Membrane Anchoring Complexes of the Type VI Secretion System ⬇️

scientific article published on 06 August 2013

Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space

scientific article published on 30 January 2018

Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex

scientific article published on 26 June 2017

Type VI secretion and bacteriophage tail tubes share a common assembly pathway

scientific article

VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors

scientific article published on 17 July 2014

and high-resolution cryo-EM structure of a bacterial type VI secretion system membrane complex

scientific article published on 15 March 2019

List of works by Eric Cascales

A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery.

A unique bacterial secretion machinery with multiple secretion centers

Activity and Crystal Structure of the Adherent-Invasive Escherichia coli Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model

Agrobacterium VirB10, an ATP energy sensor required for type IV secretion

An Agrobacterium VirB10 mutation conferring a type IV secretion system gating defect.

An Epigenetic Switch Involving Overlapping Fur and DNA Methylation Optimizes Expression of a Type VI Secretion Gene Cluster ⬇️

Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.

Anchoring the type VI secretion system to the peptidoglycan: TssL, TagL, TagP... what else?

Architecture and assembly of the Type VI secretion system.

Biogenesis and structure of a type VI secretion baseplate

Biogenesis and structure of a type VI secretion membrane core complex

Biogenesis, architecture, and function of bacterial type IV secretion systems

Characterization of the Porphyromonas gingivalis Type IX Secretion Trans-envelope PorKLMNP Core Complex

Colicin biology

Crystal structure and self-interaction of the type VI secretion tail-tube protein from enteroaggregative Escherichia coli.

Crystal structure of the VgrG1 actin cross-linking domain of the Vibrio cholerae type VI secretion system

DNA substrate-induced activation of the Agrobacterium VirB/VirD4 type IV secretion system.

Dissection of the TssB-TssC interface during type VI secretion sheath complex formation

Domestication of a housekeeping transglycosylase for assembly of a Type VI secretion system.

Energetic components VirD4, VirB11 and VirB4 mediate early DNA transfer reactions required for bacterial type IV secretion.

Energetics of colicin import revealed by genetic cross-complementation between the Tol and Ton systems ⬇️

Expression of a Yersinia pseudotuberculosis Type VI Secretion System Is Responsive to Envelope Stresses through the OmpR Transcriptional Activator

Fusion Reporter Approaches to Monitoring Transmembrane Helix Interactions in Bacterial Membranes.

H-NS Silencing of the Salmonella Pathogenicity Island 6-Encoded Type VI Secretion System Limits Salmonella enterica Serovar Typhimurium Interbacterial Killing.

HxcQ liposecretin is self-piloted to the outer membrane by its N-terminal lipid anchor

IHF is required for the transcriptional regulation of the Desulfovibrio vulgaris Hildenborough orp operons.

Imaging type VI secretion-mediated bacterial killing.

In situ and high-resolution Cryo-EM structure of the Type VI secretion membrane complex

In vivo TssA proximity labelling during type VI secretion biogenesis reveals TagA as a protein that stops and holds the sheath

Inhibition of type VI secretion by an anti-TssM llama nanobody

Inside the Chamber of Secrets of the Type III Secretion System.

Interaction of the Colicin K Bactericidal Toxin with Components of Its Import Machinery in the Periplasm of Escherichia coli ⬇️

Mapping the Interactions between Escherichia coli TolQ Transmembrane Segments ⬇️

Mapping the interactions between escherichia coli tol subunits: rotation of the TolR transmembrane helix.

Measure of Peptidoglycan Hydrolase Activity.

Meeting report: Adaptation and communication of bacterial pathogens

Microbiology: And Amoebophilus Invented the Machine Gun!

Molecular Dissection of the Interface between the Type VI Secretion TssM Cytoplasmic Domain and the TssG Baseplate Component.

Movements of the TolR C-terminal domain depend on TolQR ionizable key residues and regulate activity of the Tol complex.

Mutational analyses define helix organization and key residues of a bacterial membrane energy-transducing complex.

Nooks and crannies in type VI secretion regulation.

Pal Lipoprotein ofEscherichia coliPlays a Major Role in Outer Membrane Integrity ⬇️

Priming and polymerization of a bacterial contractile tail structure

Probing Inner Membrane Protein Topology by Proteolysis.

Promoter Swapping Unveils the Role of the Citrobacter rodentium CTS1 Type VI Secretion System in Interbacterial Competition ⬇️

Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

Proton motive force drives the interaction of the inner membrane TolA and outer membrane pal proteins in Escherichia coli

Regulation of Type VI Secretion Gene Clusters by σ 54 and Cognate Enhancer Binding Proteins ⬇️

Role and Recruitment of the TagL Peptidoglycan-Binding Protein during Type VI Secretion System Biogenesis

Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut

Structural Characterization and Oligomerization of the TssL Protein, a Component Shared by Bacterial Type VI and Type IVb Secretion Systems

Structural and dynamic properties of bacterial type IV secretion systems (review).

Structural basis for loading and inhibition of a bacterial T6SS phospholipase effector by the VgrG spike

Structural biology of type VI secretion systems ⬇️

Structure and regulation of the type VI secretion system

Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli.

Structure-Function Analysis of the C-Terminal Domain of the Type VI Secretion TssB Tail Sheath Subunit

Structure-Function Analysis of the TssL Cytoplasmic Domain Reveals a New Interaction between the Type VI Secretion Baseplate and Membrane Complexes

T6SS: killing two bugs with one stone

The C‐tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci‐1 Type VI secretion system, is inserted by YidC ⬇️

The PorX Response Regulator of the Porphyromonas gingivalis PorXY Two-Component System Does Not Directly Regulate the Type IX Secretion Genes but Binds the PorL Subunit

The SciZ protein anchors the enteroaggregative Escherichia coli Type VI secretion system to the cell wall

The Tol-Pal proteins of the Escherichia coli cell envelope: an energized system required for outer membrane integrity?

The TolQ–TolR proteins energize TolA and share homologies with the flagellar motor proteins MotA–MotB ⬇️

The Type VI Secretion System in Escherichia coli and Related Species.

The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization

The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube Assembly

The type VI secretion toolkit

The versatile bacterial type IV secretion systems

Tol-dependent macromolecule import through the Escherichia coli cell envelope requires the presence of an exposed TolA binding motif.

Towards a Structural Comprehension of Bacterial Type VI Secretion Systems: Characterization of the TssJ-TssM Complex of an Escherichia coli Pathovar

Towards a complete structural deciphering of Type VI secretion system

Tryptophan-mediated dimerization of the TssL transmembrane anchor is required for Type VI secretion system activity.

TssA: The cap protein of the Type VI secretion system tail.

TssK Is a Trimeric Cytoplasmic Protein Interacting with Components of Both Phage-like and Membrane Anchoring Complexes of the Type VI Secretion System ⬇️

Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space

Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex

Type VI secretion and bacteriophage tail tubes share a common assembly pathway