List of works - Prashant S Kharkar

A novel series of substituted 1,2,3-triazoles as cancer stem cell inhibitors: Synthesis and biological evaluation

scientific article published on 12 August 2020

A proposed model of Mycobacterium avium complex dihydrofolate reductase and its utility for drug design.

scientific article published in April 2003

Attenuation of quorum sensing-regulated behaviour by Tinospora cordifolia extract & identification of its active constituents

scientific article published on July 2016

Biomass and waste materials as potential sources of nanocrystalline cellulose: Comparative review of preparation methods (2016 - Till date)

scientific article published on 05 December 2018

Cancer Stem Cell (CSC) Inhibitors in Oncology-A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives

scientific article published on 16 December 2020

Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).

scientific article

Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives.

scientific article published on 16 May 2014

Computational Approaches for the Design of (Mutant-)Selective Tyrosine Kinase Inhibitors: State-of-the-Art and Future Prospects

scientific article published on 01 May 2020

Design, synthesis and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2

scientific article published on 04 April 2019

Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents.

scientific article published on 7 July 2016

Design, synthesis and biological evaluation of novel inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.

scientific article published on 10 May 2013

Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors

scientific article published on 01 November 2018

Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents

scientific article published on 10 February 2017

Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents

scientific article published on 07 September 2018

Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors.

scientific article

Discovery of thiazolyl-phthalazinone acetamides as potent glucose uptake activators via high-throughput screening.

scientific article

Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets.

scientific article published on 06 February 2014

Emerging roles of system [Formula: see text] antiporter and its inhibition in CNS disorders

scientific article

Fluorescent probes for biomedical applications (2009-2014).

scientific article

Highly selective on-off fluorescence recognition of Fe3+ based on a coumarin derivative and its application in live-cell imaging.

scientific article

Hit discovery of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase, GuaB2, inhibitors.

scientific article published on 18 April 2018

Hybrids of Steroid and Nitrogen Mustard as Antiproliferative Agents: Synthesis, In Vitro Evaluation and In Silico Inverse Screening.

scientific article published on 26 September 2017

In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression.

scientific article published on 19 August 2015

In vivo pharmacokinetic interaction by ethanolic extract of Gymnema sylvestre with CYP2C9 (Tolbutamide), CYP3A4 (Amlodipine) and CYP1A2 (Phenacetin) in rats.

scientific article published on 14 October 2017

In-silico identification of small molecules targeting H-Ras and in-vitro cytotoxicity with caspase-mediated apoptosis in carcinoma cells

scientific article published on 26 October 2018

Inhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff's bases incorporating iminoureido moieties

scientific article published on 04 September 2015

Inosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.

scientific article published on August 2015

Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.

scientific article

Investigation of HSA as a biocompatible coating material for arsenic trioxide nanoparticles

scientific article published on 01 May 2018

Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors

scientific article published on April 2013

Molecular docking prediction and in vitro studies elucidate anti-cancer activity of phytoestrogens.

scientific article

Newer human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents.

scientific article published in December 2018

Novel analogs of sulfasalazine as system xc - antiporter inhibitors: Insights from the molecular modeling studies

scientific article published on 14 June 2019

Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2

scientific article published on 10 December 2018

Reverse docking: a powerful tool for drug repositioning and drug rescue

scientific article published on March 2014

Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model.

scientific article published on December 2008

Study of degradation behavior of besifloxacin, characterization of its degradation products by LC-ESI-QTOF-MS and their in silico toxicity prediction

scientific article published on 07 February 2019

Substituted chloroacetamides as potential cancer stem cell inhibitors: Synthesis and biological evaluation

scientific article published on 04 December 2019

Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters

scientific article

Targeting heat shock protein 90 for malaria

scientific article

Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors.

scientific article published on 4 December 2007

Understanding the Structural Requirements of Hybrid (S)-6-((2-(4-Phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol and its Analogs as D2/D3 Receptor Ligands: A Three-Dimensional Quantitative Structure-Activity Relationship

scientific article published on 01 September 2014

List of works by Prashant S Kharkar

A novel series of substituted 1,2,3-triazoles as cancer stem cell inhibitors: Synthesis and biological evaluation

A proposed model of Mycobacterium avium complex dihydrofolate reductase and its utility for drug design.

Attenuation of quorum sensing-regulated behaviour by Tinospora cordifolia extract & identification of its active constituents

Biomass and waste materials as potential sources of nanocrystalline cellulose: Comparative review of preparation methods (2016 - Till date)

Cancer Stem Cell (CSC) Inhibitors in Oncology-A Promise for a Better Therapeutic Outcome: State of the Art and Future Perspectives

Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).

Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives.

Computational Approaches for the Design of (Mutant-)Selective Tyrosine Kinase Inhibitors: State-of-the-Art and Future Prospects

Design, synthesis and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2

Design, synthesis and biological evaluation of novel azaspiro analogs of linezolid as antibacterial and antitubercular agents.

Design, synthesis and biological evaluation of novel inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.

Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors

Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents

Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents

Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors.

Discovery of thiazolyl-phthalazinone acetamides as potent glucose uptake activators via high-throughput screening.

Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets.

Emerging roles of system [Formula: see text] antiporter and its inhibition in CNS disorders

Fluorescent probes for biomedical applications (2009-2014).

Highly selective on-off fluorescence recognition of Fe3+ based on a coumarin derivative and its application in live-cell imaging.

Hit discovery of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase, GuaB2, inhibitors.

Hybrids of Steroid and Nitrogen Mustard as Antiproliferative Agents: Synthesis, In Vitro Evaluation and In Silico Inverse Screening.

In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression.

In vivo pharmacokinetic interaction by ethanolic extract of Gymnema sylvestre with CYP2C9 (Tolbutamide), CYP3A4 (Amlodipine) and CYP1A2 (Phenacetin) in rats.

In-silico identification of small molecules targeting H-Ras and in-vitro cytotoxicity with caspase-mediated apoptosis in carcinoma cells

Inhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff's bases incorporating iminoureido moieties

Inosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.

Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.

Investigation of HSA as a biocompatible coating material for arsenic trioxide nanoparticles

Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors

Molecular docking prediction and in vitro studies elucidate anti-cancer activity of phytoestrogens.

Newer human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents.

Novel analogs of sulfasalazine as system xc - antiporter inhibitors: Insights from the molecular modeling studies

Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2

Reverse docking: a powerful tool for drug repositioning and drug rescue

Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model.

Study of degradation behavior of besifloxacin, characterization of its degradation products by LC-ESI-QTOF-MS and their in silico toxicity prediction

Substituted chloroacetamides as potential cancer stem cell inhibitors: Synthesis and biological evaluation

Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters

Targeting heat shock protein 90 for malaria

Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors.

Understanding the Structural Requirements of Hybrid (S)-6-((2-(4-Phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol and its Analogs as D2/D3 Receptor Ligands: A Three-Dimensional Quantitative Structure-Activity Relationship