List of works - Tim Vanmierlo

7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice

scientific article

ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury

scientific article published on 06 March 2019

Active liver X receptor signaling in phagocytes in multiple sclerosis lesions.

scientific article published in February 2017

Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression.

scientific article published on 27 April 2018

Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver

scientific article

Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease

scientific article published in January 2010

Apolipoprotein CI knock-out mice display impaired memory functions

scientific article published in January 2011

Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations

scientific article published on 18 October 2011

CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

scientific article published on 08 June 2021

Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice

scientific article published on June 2011

Cholesterol and synaptic compensatory mechanisms in Alzheimer's disease mice brain during aging.

scientific article published in January 2012

Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats

scientific article

Corrigendum: Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes

scientific article published on 22 December 2017

DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation

scientific article published on 05 September 2021

Delivery of DNA into the central nervous system via electroporation

scientific article published on January 2014

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model

scientific article published on 20 March 2019

Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

scientific article published on 25 January 2012

Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE-/- mice

scientific article

Differential susceptibility to chronic social defeat stress relates to the number of Dnmt3a-immunoreactive neurons in the hippocampal dentate gyrus.

scientific article

Early-postnatal iron deficiency impacts plasticity in the dorsal and ventral hippocampus in piglets.

scientific article

Effects of prenatal stress exposure on soluble Aβ and brain-derived neurotrophic factor signaling in male and female APPswe/PS1dE9 mice.

scientific article published on 29 June 2012

Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice.

scientific article published on 16 February 2016

From OPC to Oligodendrocyte: An Epigenetic Journey

scientific article published on 11 October 2019

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses ⬇️

scientific article published on December 1, 2011

Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels

scientific article published on 28 February 2018

High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system

scientific article

Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling.

scientific article published on 12 May 2014

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.

scientific article

Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging.

scientific article published on 16 January 2018

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

scientific article published on 31 July 2019

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

scientific article published on 11 August 2009

Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets.

scientific article published on 26 November 2013

Low-Density Lipoprotein Receptor Deficiency Attenuates Neuroinflammation through the Induction of Apolipoprotein E.

scientific article published on 30 November 2017

Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus

scientific article published on 08 April 2011

Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

scientific article published on 24 April 2019

Methylglyoxal-Derived Advanced Glycation Endproducts in Multiple Sclerosis.

scientific article published on 15 February 2017

Myelin alters the inflammatory phenotype of macrophages by activating PPARs.

scientific article published on 02 August 2013

Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue

scientific article published in 2021

PDE5 inhibition improves object memory in standard housed rats but not in rats housed in an enriched environment: implications for memory models?

scientific article (publication date: 2014)

Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels

scientific article published on 26 July 2016

Plant sterol oxidation products – Analogs to cholesterol oxidation products from plant origin? ⬇️

scientific article published on September 23, 2012

Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study

scientific article published on October 2013

Plant sterols: Friend or foe in CNS disorders?

scientific article

Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?"

scientific article published on 26 February 2019

Progress and perspectives in plant sterol and plant stanol research

scientific article published on 01 October 2018

Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL.

scientific article published on 23 February 2017

Response to the Letter by Singh et al Regarding “Apolipoprotein Isoform E4 Does Not Increase Coronary Heart Disease Risk in Carriers of Low-Density Lipoprotein Receptor Mutations”

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

scientific article published on 19 June 2018

Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes.

scientific article

Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation

scientific article published on 13 October 2020

Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment

scientific article published on 24 July 2019

Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system.

scientific article published on 15 September 2017

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

scientific article

The plant sterol brassicasterol as additional CSF biomarker in Alzheimer's disease.

scientific article published on 17 May 2011

The role of receptor MAS in microglia-driven retinal vascular development

scientific article published on 20 June 2019

TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice

scientific article published on 24 August 2015

Twelve Weeks of Medium-Intensity Exercise Therapy Affects the Lipoprotein Profile of Multiple Sclerosis Patients

scientific article

Validation of an isotope dilution gas chromatography-mass spectrometry method for analysis of 7-oxygenated campesterol and sitosterol in human serum.

scientific article published on 19 May 2011

List of works by Tim Vanmierlo

7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice

ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury

Active liver X receptor signaling in phagocytes in multiple sclerosis lesions.

Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression.

Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver

Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease

Apolipoprotein CI knock-out mice display impaired memory functions

Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations

CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice

Cholesterol and synaptic compensatory mechanisms in Alzheimer's disease mice brain during aging.

Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats

Corrigendum: Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes

DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation

Delivery of DNA into the central nervous system via electroporation

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model

Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE-/- mice

Differential susceptibility to chronic social defeat stress relates to the number of Dnmt3a-immunoreactive neurons in the hippocampal dentate gyrus.

Early-postnatal iron deficiency impacts plasticity in the dorsal and ventral hippocampus in piglets.

Effects of prenatal stress exposure on soluble Aβ and brain-derived neurotrophic factor signaling in male and female APPswe/PS1dE9 mice.

Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice.

From OPC to Oligodendrocyte: An Epigenetic Journey

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses ⬇️

Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels

High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system

Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling.

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.

Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging.

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets.

Low-Density Lipoprotein Receptor Deficiency Attenuates Neuroinflammation through the Induction of Apolipoprotein E.

Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus

Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

Methylglyoxal-Derived Advanced Glycation Endproducts in Multiple Sclerosis.

Myelin alters the inflammatory phenotype of macrophages by activating PPARs.

Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue

PDE5 inhibition improves object memory in standard housed rats but not in rats housed in an enriched environment: implications for memory models?

Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels

Plant sterol oxidation products – Analogs to cholesterol oxidation products from plant origin? ⬇️

Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study

Plant sterols: Friend or foe in CNS disorders?

Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?"

Progress and perspectives in plant sterol and plant stanol research

Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL.

Response to the Letter by Singh et al Regarding “Apolipoprotein Isoform E4 Does Not Increase Coronary Heart Disease Risk in Carriers of Low-Density Lipoprotein Receptor Mutations”

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes.

Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation

Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment

Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system.

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

The plant sterol brassicasterol as additional CSF biomarker in Alzheimer's disease.

The role of receptor MAS in microglia-driven retinal vascular development

TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice

Twelve Weeks of Medium-Intensity Exercise Therapy Affects the Lipoprotein Profile of Multiple Sclerosis Patients

Validation of an isotope dilution gas chromatography-mass spectrometry method for analysis of 7-oxygenated campesterol and sitosterol in human serum.