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List of works by Alan H Lazarus

A monoclonal antibody with anti-D-like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects

scientific article

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy

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A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy

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A rapid and efficient microtechnique for the analysis of functional transferrin receptors on tumor cells.

scientific article published in May 1985

A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?

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Adoptive-transfer effects of intravenous immunoglobulin in autoimmunity

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Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia

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Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP?

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Amelioration of murine passive immune thrombocytopenia by IVIg and a therapeutic monoclonal CD44 antibody does not require the Myd88 signaling pathway

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Analysis of transmembrane signalling and T cell defects associated with idiopathic thrombocytopenic purpura (ITP) ⬇️

scientific article published on June 1, 1998

Anti-RhD reduces levels of detectable RhD antigen following anti-RhD infusion

scientific article published in February 2018

Antibody-mediated immune suppression is improved when blends of anti-RBC monoclonal antibodies are used in mice.

scientific article published on 21 June 2016

Antibody-mediated immune suppression of erythrocyte alloimmunization can occur independently from red cell clearance or epitope masking in a murine model

scientific article published on 13 August 2014

Antibody-mediated inhibition of the human alloimmune response to platelet transfusion in Hu-PBL-SCID mice

scientific article published on 01 March 1999

Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway.

scientific article

Antigen-induced Fc receptor-dependent and -independent B cell desensitization. An elevation in [Ca2+]i is not sufficient and protein kinase C activation is not required for these pathways of surface IgM-mediated desensitization

scientific article published on 01 September 1991

Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia

scientific article published on 01 July 2018

Applications of flow cytometry in the analysis of blood leukocytes.

scientific article

CD154 (CD40 ligand)-deficient mice exhibit prolonged bleeding time and decreased shear-induced platelet aggregates

scientific article published on 01 April 2003

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia

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CD44 Antibody Inhibition of Macrophage Phagocytosis Targets Fcγ Receptor- and Complement Receptor 3-Dependent Mechanisms.

scientific article published on 04 March 2016

CD44 antibodies and immune thrombocytopenia in the amelioration of murine inflammatory arthritis

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CD44 antibody-mediated amelioration of murine immune thrombocytopenia (ITP): mouse background determines the effect of FcγRIIb genetic disruption

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CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

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Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease?

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Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis ⬇️

scientific article published on June 1, 1991

Erythrocyte Saturation with IgG Is Required for Inducing Antibody-Mediated Immune Suppression and Impacts Both Erythrocyte Clearance and Antigen-Modulation Mechanisms.

scientific article

Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity

scientific article published on 01 January 1999

Flow cytometric analysis of platelets from childrenwith the Wiskott‐Aldrich syndrome reveals defects in platelet development, activation and structure ⬇️

scientific article published on June 1, 1997

GPIbα is required for platelet-mediated hepatic thrombopoietin generation

scientific article published on 24 May 2018

Gamma-globulins prepared from sera of multiparous women bind anti-HLA antibodies and inhibit an established in vivo human alloimmune response.

scientific article

Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation.

scientific article published on 4 August 2011

IVIG induces dose-dependent amelioration of ITP in rodent models

scientific article published on 01 February 2003

IVIg conducts DC-platelet nuptials ⬇️

scientific article published on 01 December 2010

IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivity.

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IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity

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IgG-Mediated Immune Suppression to Erythrocytes by Polyclonal Antibodies Can Occur in the Absence of Activating or Inhibitory Fcγ Receptors in a Full Mouse Model

scientific article published on 17 July 2015

IgG-mediated immunosuppression is not dependent on erythrocyte clearance or immunological evasion: implications for the mechanism of action of anti-D in the prevention of haemolytic disease of the newborn?

scientific article published in October 2007

Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype

scientific article published on 01 November 2004

Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb.

scientific article published in September 2011

Immunoglobulin G Fc glycans are not essential for antibody-mediated immune suppression to murine erythrocytes

scientific article published on 6 November 2017

Immunoglobulin G-mediated regulation of the murine immune response to transfused red blood cells occurs in the absence of active immune suppression: implications for the mechanism of action of anti-D in the prevention of haemolytic disease of the fe

scientific article published on 7 February 2008

Induction of a secondary human anti-HLA alloimmune response in severe combined immunodeficient mice engrafted with human lymphocytes

scientific article published on 01 November 1997

Inhibition of a secondary human alloimmune response via the soluble active component of CD154 (CD40L) in severe combined immune-deficient mice engrafted with human lymphocytes.

scientific article published in August 1999

Innate and adaptive immunity in immune thrombocytopenia

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Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice

scientific article

Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells

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Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia

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Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production

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Mechanism of action of IVIG and anti-D in ITP ⬇️

scientific article published on June 1, 2003

Mechanism of action of IVIG in ITP.

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Mechanisms of action of intravenous immunoglobulin in the treatment of immune thrombocytopenia

scientific article

Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn.

scientific article published on January 2009

Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn: what can we learn from rodent models?

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Mechanisms of platelet recovery in ITP associated with therapy.

scientific article

Mechanistic properties of intravenous immunoglobulin in murine immune thrombocytopenia: support for FcγRIIB falls by the wayside

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Monoclonal IgG can ameliorate immune thrombocytopenia in a murine model of ITP: an alternative to IVIG.

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Monoclonal antibodies that mimic the action of anti-D in the amelioration of murine ITP act by a mechanism distinct from that of IVIg

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Monoclonal antibody-mediated inhibition of the human HLA alloimmune response to platelet transfusion is antigen specific and independent of Fcgamma receptor-mediated immune suppression

scientific article published on 01 August 2000

Monoclonal versus polyclonal anti-D in the treatment of ITP.

scientific article

Monovalent Fc receptor blockade by an anti-Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity

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Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk.

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Permeabilization and fixation conditions for intracellular flow cytometric detection of the T-cell receptor ? chain and other intracellular proteins in lymphocyte subpopulations ⬇️

scientific article published on July 1, 1998

Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo

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Platelet activation and hypercoagulability following treatment with porcine factor VIII (HYATE:C).

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Platelet activation induced by porcine factor VIII (Hyate:C).

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Porcine von Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase (JNK/SAPK) whereas only thrombin induces activation of extracellular signal-related kinase 2 (ERK2) in human platelets

scientific article published on 01 June 2000

Preanalytical requirements for flow cytometric evaluation of platelet activation: choice of anticoagulant

scientific article published on 01 June 1999

Prevention of hemolytic disease of the fetus and newborn: what have we learned from animal models?

scientific article

Red Blood Cell Antibody Induced Anemia Causes Differential Degrees of Tissue Hypoxia in Kidney and Brain.

scientific article published on 10 January 2018

Regulation of BCR- and PKC/Ca(2+)-mediated activation of the Raf1/MEK/MAPK pathway by protein-tyrosine kinase and -tyrosine phosphatase activities.

scientific article published on February 1996

RhD Specific Antibodies Are Not Detectable in HLA-DRB1(*)1501 Mice Challenged with Human RhD Positive Erythrocytes.

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Role of Fcgamma receptors in the pathogenesis and treatment of idiopathic thrombocytopenic purpura

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Studies on the mechanism of specificity of human natural killer cells for tumor cells: correlation between target cell transferrin receptor expression and competitive activity

scientific article published on 01 December 1985

Targeting FcγRs to treat antibody-dependent autoimmunity

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The cellular immunology associated with autoimmune thrombocytopenic purpura: an update.

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The mechanisms of action of intravenous immunoglobulin and polyclonal anti-d immunoglobulin in the amelioration of immune thrombocytopenic purpura: what do we really know?

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The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia

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Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils.

scientific article published on 23 April 2014

Transfusion of IgG-opsonized foreign red blood cells mediates reduction of antigen-specific B cell priming in a murine model.

scientific article published in July 2008

Transfusion of antibody-opsonized red blood cells results in a shift in the immune response from the red blood cell to the antibody in a murine model.

scientific article published in September 2010

Treating murine inflammatory diseases with an anti-erythrocyte antibody

scientific article published on 01 August 2019

p38 MAPK is activated but not necessary in porcine von Willebrand factor-dependent platelet activation

scientific article published on 01 December 1999

von Willebrand factor (VWF)-dependent human platelet activation: porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function

scientific article

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