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List of works by Felix Hernandez

A Simple Model to Study Tau Pathology.

scientific article

Absence of CX3CR1 impairs the internalization of Tau by microglia.

scientific article published on 15 August 2017

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

scientific article published in March 2010

Alpha-helix structure in Alzheimer's disease aggregates of tau-protein.

scientific article

Alternative neural circuitry that might be impaired in the development of Alzheimer disease

scientific article

Alzheimer disease-like cellular phenotype of newborn granule neurons can be reversed in GSK-3β-overexpressing mice.

scientific article

Argyrophilic grain pathology as a natural model of tau propagation.

scientific article published in January 2014

Assembly in vitro of tau protein and its implications in Alzheimer's disease.

scientific article

Binding of tau protein to the ends of ex vivo paired helical filaments.

scientific article

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

scientific article published in October 2004

Boronate-tau mediated uptake in neurons.

scientific article published in January 2014

Calpain regulates N-terminal interaction of GSK-3β with 14-3-3ζ, p53 and PKB but not with axin ⬇️

scientific article published on June 13, 2011

Calpain-mediated truncation of GSK-3 in post-mortem brain samples.

scientific article

Centro de Biologia Molecular "Severo Ochoa": a center for basic research into Alzheimer's disease.

scientific article published in January 2010

Changes in tau phosphorylation in hibernating rodents.

scientific article published on 19 April 2013

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

scientific article published on 24 October 2006

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

scientific article published in August 2003

Coenzyme Q Induces Tau Aggregation, Tau Filaments, and Hirano Bodies

scientific article published on 01 May 2008

Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins.

scientific article published on 10 November 2017

Commentary: Genome-wide association study identifies 74 loci associated with educational attainment.

scientific article published on 31 January 2017

Decreased adult neurogenesis in hibernating Syrian hamster

scientific article published on 16 July 2016

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.

scientific article published on 16 June 2015

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

scientific article

Differences Between Human and Murine Tau at the N-terminal End

scientific article published on 28 January 2020

Differences in structure and function between human and murine tau

scientific article published on 12 August 2018

Different susceptibility to neurodegeneration of dorsal and ventral hippocampal dentate gyrus: a study with transgenic mice overexpressing GSK3β.

scientific article

Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo.

scientific article published on 28 November 2015

Dissociation between secretion and protein phosphorylation in agonist-stimulated platelets; action of PCA-4230, a new antithrombotic drug

scientific article published on 01 July 1994

Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo

scientific article

Endothelin inhibits histamine-induced cyclic AMP accumulation in bovine brain vessels

scientific article published on 01 July 2000

Endothelin stimulates protein phosphorylation in blood-brain barrier.

scientific article published in February 1996

Endothelin-1 increases isoprenaline-enhanced cyclic AMP levels in cerebral cortex

scientific article published on 01 March 2000

Endothelin-1 stimulates myristoylated alanine-rich C-kinase substrate (MARCKS) phosphorylation in rat cerebellar slices

scientific article published on 01 July 1995

Enhanced induction of the immunoproteasome by interferon gamma in neurons expressing mutant Huntingtin.

scientific article published in January 2004

Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.

scientific article published on 22 December 2017

Excitotoxicity induced by kainic acid provokes glycogen synthase kinase-3 truncation in the hippocampus

scientific article

Expression of frontotemporal dementia with parkinsonism associated to chromosome 17 tau induces specific degeneration of the ventral dentate gyrus and depressive-like behavior in mice.

scientific article published on 27 August 2011

Extracellular Monomeric Tau Is Internalized by Astrocytes

scientific article published on 01 May 2019

Extracellular tau is toxic to neuronal cells.

scientific article published on 8 August 2006

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain

scientific article published on 01 December 2001

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

scientific article

Function of tau protein in adult newborn neurons

scientific journal article

Further studies on the mechanism of action of substance P in rat brain, involving selective phosphatidylinositol hydrolysis

scientific article published on 01 October 1995

GSK-3 inhibitors for Alzheimer's disease.

scientific article published on November 2007

GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo.

scientific article published on 12 February 2013

GSK-3β, a pivotal kinase in Alzheimer disease.

scientific article

GSK3 and tau: two convergence points in Alzheimer's disease.

scientific article published on January 2013

GSK3 inhibitors and disease.

scientific article published on August 2009

GSK3: a possible link between beta amyloid peptide and tau protein.

scientific article published on 24 September 2009

GSK3β Overexpression in Dentate Gyrus Neural Precursor Cells Expands the Progenitor Pool and Enhances Memory Skills.

scientific article

GSK3β overexpression driven by GFAP promoter improves rotarod performance

scientific article published on 31 January 2019

GSK3β overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus.

scientific article

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

scientific article

Glycogen synthase kinase-3β regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer's disease

scientific article

Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.

scientific article

Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

scientific article published on 20 July 2014

Identification of nitric oxide synthases in isolated bovine brain vessels

scientific article published on 01 June 1996

In vitro tau fibrillization: mapping protein regions.

scientific article published on 9 June 2006

Induction of paclitaxel resistance by the Kaposi's sarcoma-associated herpesvirus latent protein LANA2.

scientific article published on 21 November 2007

Intra- and extracellular protein interactions with tau.

scientific article published on December 2010

Intracellular and extracellular microtubule associated protein tau as a therapeutic target in Alzheimer disease and other tauopathies.

scientific article

Involvement of calcium in phosphoinositide metabolism in the blood-brain barrier

scientific article published on 01 March 1995

Lithium as a Treatment for Alzheimer's Disease: The Systems Pharmacology Perspective

scientific article published on 01 January 2019

Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy

scientific article published in 2023

Looking for novel functions of tau.

scientific article published on August 2012

M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway

scientific article published on 01 November 2004

MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus

article

Microtubule depolymerization and tau phosphorylation.

scientific article published on January 2013

Natriuretic peptide-induced cyclic GMP accumulation in adult guinea-pig cerebellar slices.

scientific article

Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.

scientific article published on 17 May 2007

Neuronal models for studying tau pathology.

scientific article published on 19 July 2010

New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy.

scientific article published on 16 March 2018

New Features about Tau Function and Dysfunction

scientific article

Novel connection between newborn granule neurons and the hippocampal CA2 field

scientific article published on November 2014

Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis

scientific article

Peripheral nervous system effects in the PS19 tau transgenic mouse model of tauopathy

scientific article published on 21 January 2019

Peripherally triggered and GSK-3β-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen.

scientific article

Pertussis toxin-insensitive regulation of phosphatidylinositol hydrolysis by vanadate in brain microvessels

scientific article published on December 1, 1991

Phospho-Tau Accumulation and Structural Alterations of the Golgi Apparatus of Cortical Pyramidal Neurons in the P301S Tauopathy Mouse Model

scientific article published on 8 September 2017

Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression

scientific article published on 01 January 2019

Phosphorylation modulates the alpha-helical structure and polymerization of a peptide from the third tau microtubule-binding repeat.

scientific article published on 5 November 2004

Profiling of Argonaute-2-loaded microRNAs in a mouse model of frontotemporal dementia with parkinsonism-17

scientific article published on 25 December 2018

Propagation of Tau via Extracellular Vesicles

scientific article published on 02 July 2019

Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

scientific article published in November 2001

Protein phosphorylation in the blood-brain barrier. Possible presence of MARCKS in brain microvessels

scientific article published on 01 January 1996

Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer's disease

scientific article published on 28 October 2019

Role of calcium on protein phosphorylation in collagen-stimulated platelets. Effect of a new dihydropyridine derivative

scientific article published on 01 October 1989

Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors.

scientific article published on May 2010

Role of neuroinflammation in adult neurogenesis and Alzheimer disease: therapeutic approaches

scientific article published on 3 April 2013

Role of polyglycine repeats in the regulation of glycogen synthase kinase activity.

scientific article published on January 2008

Role of tau protein in both physiological and pathological conditions.

scientific article published on April 2004

Secretion of full-length tau or tau fragments in a cell culture model.

scientific article published on 17 September 2016

Selective alterations of neurons and circuits related to early memory loss in Alzheimer's disease.

scientific article

Sources of extracellular tau and its signaling.

scientific article published on January 2014

TNAP Plays a Key Role in Neural Differentiation as well as in Neurodegenerative Disorders.

scientific article published on January 2015

Tau Overexpression Results in Its Secretion via Membrane Vesicles

scientific article published on 21 January 2012

Tau Protein and Adult Hippocampal Neurogenesis ⬇️

scientific article published on 09 July 2012

Tau Spreading Mechanisms; Implications for Dysfunctional Tauopathies.

scientific article published on 25 February 2018

Tau Structures

scientific article

Tau aggregates and tau pathology.

scientific article published on August 2008

Tau as a molecular marker of development, aging and neurodegenerative disorders.

scientific article published on March 2008

Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease.

scientific article

Tau phosphorylation in hippocampus results in toxic gain-of-function.

scientific article published on August 2010

Tau triggers tear secretion by interacting with muscarinic acetylcholine receptors in New Zealand white rabbits.

scientific article published in January 2014

Tau-positive nuclear indentations in P301S tauopathy mice.

scientific article published on 24 June 2016

Testing the ubiquitin-proteasome hypothesis of neurodegeneration in vivo.

scientific article published on February 2004

Tetrahydroaminoacridine affects the cholinergic function of blood-brain barrier.

scientific article published in January 1993

The involvement of cholinergic neurons in the spreading of tau pathology.

scientific article

The role of GSK3 in Alzheimer disease.

scientific article published on 27 May 2009

The role of glycogen synthase kinase 3 in the early stages of Alzheimers' disease.

scientific article published on 26 October 2008

The ubiquitin-proteasome system in Huntington's disease.

scientific article

Thermodynamics of the interaction between Alzheimer's disease related tau protein and DNA

scientific article

Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau.

scientific article

Transgenic mouse models with tau pathology to test therapeutic agents for Alzheimer's disease.

scientific article

Validation of Suspected Somatic Single Nucleotide Variations in the Brain of Alzheimer's Disease Patients.

scientific article published on 19 January 2017

p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model

scientific article published on 08 February 2022

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