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List of works by Javier A Menendez

A 2-D-HPLC-CE platform coupled to ESI-TOF-MS to characterize the phenolic fraction in olive oil

scientific article published on 01 August 2009

A comparison of non-biologically active truncated EGF (EGFt) and full-length hEGF for delivery of Auger electron-emitting 111In to EGFR-positive breast cancer cells and tumor xenografts in athymic mice.

scientific article published on 19 August 2015

A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.

scientific article

A possible role for CCR5 in the progression of atherosclerosis in HIV-infected patients: a cross-sectional study.

scientific article published on 9 May 2013

AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase

scientific article

AMPK: a bona fide resident of the mitotic spindle midzone.

scientific article published in March 2012

ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations.

scientific article published on 2 April 2008

Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome

scientific article published on 02 March 2016

Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile

scientific article

Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells

scientific article published on March 2012

Activation of the methylation cycle in cells reprogrammed into a stem cell-like state.

scientific article published on January 2015

AlphaVbeta3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer.

scientific article

An easy, rapid and objective mathematical method to identify fatty acid synthase (oncogenic antigen-519) modulators with potential anticancer value.

scientific article

An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa) -induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (Review).

scientific article published on July 2007

Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays.

scientific article

Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands

scientific article

Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties

scientific article published on 13 May 2015

Antibody microarray-based technology to rapidly define matrix metalloproteinase (MMP) signatures in patients undergoing resection for primary gastric carcinoma

scientific article published on 09 February 2011

Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene

scientific article

Assessment of extracellular matrix-related biomarkers in patients with lower extremity artery disease

scientific article published on 31 March 2018

Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab

scientific article

Autophagy in stem cells

scientific article

Autophagy is an inflammation-related defensive mechanism against disease.

scientific article published on January 2014

Axial chirality of 4-arylpyrazolo[3,4-b]pyridines. Conformational analysis and absolute configuration

scientific article published on 07 November 2014

BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer

scientific article

BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells

scientific article

Basal/HER2 breast carcinomas: integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin).

scientific article published on 15 January 2012

Blockade of a key region in the extracellular domain inhibits HER2 dimerization and signaling.

scientific article

CCN1 promotes vascular endothelial growth factor secretion through αvβ 3 integrin receptors in breast cancer

scientific article published on 12 December 2013

Cancer stem cell-driven efficacy of trastuzumab (Herceptin): towards a reclassification of clinically HER2-positive breast carcinomas

scientific article published on 12 October 2015

Characterization and quantification of phenolic compounds of extra-virgin olive oils with anticancer properties by a rapid and resolutive LC-ESI-TOF MS method.

scientific article

Circulating fatty acid synthase: an exploratory biomarker to predict efficacy of the dual HER1/HER2 tyrosine kinase inhibitor lapatinib

scientific article

Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer

scientific article published on 7 October 2016

Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice.

scientific article

Crude phenolic extracts from extra virgin olive oil circumvent de novo breast cancer resistance to HER1/HER2-targeting drugs by inducing GADD45-sensed cellular stress, G2/M arrest and hyperacetylation of Histone H3.

scientific article published on 30 March 2011

Diagnostic utility of mammaglobin and GCDFP-15 in the identification of primary neuroendocrine carcinomas of the breast ⬇️

scientific article published on October 27, 2010

Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells

scientific article published on 01 November 2004

Direct antitumour activity of zoledronic acid: preclinical and clinical data

scientific article

Direct characterization of aqueous extract of Hibiscus sabdariffa using HPLC with diode array detection coupled to ESI and ion trap MS.

scientific article published in October 2009

Discordant expression of molecular markers between primary and nodal metastases: a histopathological manifestation of the 'self (stem cell)-seeding' nature of breast cancer disease?

scientific article published on 23 December 2009

Dynamic emergence of the mesenchymal CD44(pos)CD24(neg/low) phenotype in HER2-gene amplified breast cancer cells with de novo resistance to trastuzumab (Herceptin).

scientific article

Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene.

scientific article published on November 2005

Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells

scientific article

Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer

scientific article

EphA2 receptor activation with ephrin-A1 ligand restores cetuximab efficacy in NRAS-mutant colorectal cancer cells

scientific article published on 30 May 2017

Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive computational model.

scientific article

Epigenetics and nutrition-related epidemics of metabolic diseases: Current perspectives and challenges

scientific article

Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin).

scientific article published on 19 September 2012

Evolution of the predictive markers amphiregulin and epiregulin mRNAs during long-term cetuximab treatment of KRAS wild-type tumor cells

scientific article published on 16 December 2010

Exploring the Process of Energy Generation in Pathophysiology by Targeted Metabolomics: Performance of a Simple and Quantitative Method.

scientific article published on 17 September 2015

Expression status of the autophagy-regulatory gene ATG6/BECN1 in ERBB2-positive breast carcinomas: bypassing ERBB2-induced oncogenic senescence to regulate the efficacy of ERBB2-targeted therapies

scientific article published on 03 January 2011

Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells

scientific article published on 14 February 2018

Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance ⬇️

scientific article

Fatty Acid Synthase Is a Key Enabler for Endocrine Resistance in Heregulin-Overexpressing Luminal B-Like Breast Cancer

scientific article published on 16 October 2020

Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75.

scientific article published on 28 September 2007

Fatty acid synthase (FASN) as a therapeutic target in breast cancer.

scientific article published on 18 September 2017

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

scientific article (publication date: October 2007)

Fatty acid synthase regulates estrogen receptor-α signaling in breast cancer cells.

scientific article published on 27 February 2017

Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives.

scientific article published on 24 September 2009

Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, auroras and polo-like kinases] M-phase cell cycle genes in human breast cancer cells.

scientific article published on 13 May 2009

Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.

scientific article published on 31 May 2016

Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites.

scientific article

Giacomo Castelvetro's salads. Anti-HER2 oncogene nutraceuticals since the 17th century?

scientific article published on January 2008

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Her-2/neu-induced "cytokine signature" in breast cancer.

scientific article published in January 2008

Heregulin Drives Endocrine Resistance by Altering IL-8 Expression in ER-Positive Breast Cancer

scientific article published on 19 October 2020

Heregulin, a new interactor of the telosome/shelterin complex in human telomeres.

scientific article published on 22 July 2015

Heregulin, a new regulator of telomere length in human cells

scientific article published on 22 July 2015

Hibiscus sabdariffaextract lowers blood pressure and improves endothelial function

scientific article published on 24 February 2014

Human immunodeficiency virus infection as a model of premature aging: perspectives and implications ⬇️

scientific article published on March 16, 2012

IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations

scientific article published on January 2013

Identification of active compounds in vegetal extracts based on correlation between activity and HPLC-MS data.

scientific article

Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology.

scientific article published on 2 November 2009

Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection

scientific article

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

scientific article

Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis.

scientific article published in January 2005

Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells.

scientific article published on August 2004

Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/ neu -overexpressing human breast cancer cells to docetaxel (taxotere).

scientific article published on March 2004

Inhibitor of Apoptosis (IAP) survivin is indispensable for survival of HER2 gene-amplified breast cancer cells with primary resistance to HER1/2-targeted therapies

article

Interferon/STAT1 and neuregulin signaling pathways are exploratory biomarkers of cetuximab (Erbitux®) efficacy in KRAS wild-type squamous carcinomas: a pathway-based analysis of whole human-genome microarray data from cetuximab-adapted tumor cell-li

scientific article

Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers ⬇️

scientific article published on 31 March 2019

Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-related disturbances in hypertrophic adipocytes through AMPK-dependent mechanisms.

scientific article published on 10 April 2015

Liver fat deposition and mitochondrial dysfunction in morbid obesity: An approach combining metabolomics with liver imaging and histology

scientific article published on June 2015

Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HER1/HER2 tyrosine kinase inhibitor lapatinib (Tykerb) in human breast carcinoma cells.

scientific article published on 17 February 2008

Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin

scientific article

Managing hypertension by polyphenols.

scientific article

Mapping of the circulating metabolome reveals α-ketoglutarate as a predictor of morbid obesity-associated non-alcoholic fatty liver disease

scientific article published on 28 March 2014

Mediterranean diet, olive oil and cancer.

scientific article

Metabolic control of cancer cell stemness: Lessons from iPS cells

scientific article

Metabolic stress in infected cells may represent a therapeutic target for human immunodeficiency virus infection.

scientific article published on 29 April 2013

Metabolomic mapping of cancer stem cells for reducing and exploiting tumor heterogeneity

scientific article published on 15 October 2017

Metabostemness: Metaboloepigenetic reprogramming of cancer stem-cell functions

scientific article published on 26 December 2014

Metabostemness: a new cancer hallmark.

scientific article

Metformin Potentiates the Benefits of Dietary Restraint: A Metabolomic Study.

scientific article

Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response

scientific article published on 01 May 2011

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.

scientific article published on 15 November 2010

Metformin and energy metabolism in breast cancer: from insulin physiology to tumour-initiating stem cells.

scientific article published on October 2010

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX

scientific article published on 08 May 2018

Metformin inhibits RANKL and sensitizes cancer stem cells to denosumab

scientific article

Metformin is synthetically lethal with glucose withdrawal in cancer cells.

scientific article

Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.

scientific article

Metformin targets histone acetylation in cancer-prone epithelial cells

scientific article published on 28 October 2016

Metformin: a cheap and well-tolerated drug that provides benefits for viral infections.

scientific article published on 21 November 2012

Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a ⬇️

scientific article published on April 1, 2011

Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities

scientific article published on 28 February 2013

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

scientific article published on 13 June 2016

Mitostemness

scientific article published on 02 July 2018

Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties

scientific article published on January 2014

Neoadjuvant Metformin Added to Systemic Therapy Decreases the Proliferative Capacity of Residual Breast Cancer

scientific article published on 11 December 2019

Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.

scientific article published on March 2004

Nuclear reprogramming of cancer stem cells: Corrupting the epigenetic code of cell identity with oncometabolites

scientific article published on 28 March 2016

Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway

scientific article published on 21 August 2013

Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.

scientific article published on 10 February 2017

Nutritional Niches of Cancer Therapy-Induced Senescent Cells

scientific article published in 2022

Obesity, fatty acid synthase, and cancer: serendipity or forgotten causal linkage?

scientific article published on 09 December 2004

Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells.

scientific article published on 9 May 2007

Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression.

scientific article

Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells.

scientific article published on July 2006

Oncometabolic Nuclear Reprogramming of Cancer Stemness

scientific article published on 27 January 2016

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.

scientific article published on May 2015

Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-li

scientific article

Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells

scientific article published on February 2008

Pediatric solid organ transplant recipients: transition to home and chronic illness care

scientific article

Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation.

scientific article published on November 2004

Pharmacological mimicking of caloric restriction elicits epigenetic reprogramming of differentiated cells to stem-like self-renewal states.

scientific article published on October 2010

Phenolic secoiridoids in extra virgin olive oil impede fibrogenic and oncogenic epithelial-to-mesenchymal transition: extra virgin olive oil as a source of novel antiaging phytochemicals.

scientific article published on 9 January 2012

Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

scientific article published on 5 April 2012

Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease

scientific article published on 20 September 2018

Polo-like kinase 1 directs the AMPK-mediated activation of myosin regulatory light chain at the cytokinetic cleavage furrow independently of energy balance

scientific article

Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus.

scientific article published on 15 April 2011

Polyphenols and the modulation of gene expression pathways: can we eat our way out of the danger of chronic disease?

scientific article

Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2'-O-Methylation of Viral RNA

scientific article published on 10 May 2020

Prediction of extra virgin olive oil varieties through their phenolic profile. Potential cytotoxic activity against human breast cancer cells.

scientific article published on September 2010

Pro-Oxidant Activity of Amine-Pyridine-Based Iron Complexes Efficiently Kills Cancer and Cancer Stem-Like Cells

scientific article published on 14 September 2015

Protein array technology to detect HER2 (erbB-2)-induced 'cytokine signature' in breast cancer.

scientific article published on 26 March 2007

Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)

scientific article published on 15 September 2011

Recommendations of the Spanish Brachytherapy Group of SEOR for HDR endoluminal treatments. Part 1: Oesophagus

scientific article published on 17 April 2015

Rejuvenating regeneration: metformin activates endogenous adult stem cells.

scientific article published on 30 August 2012

Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions

scientific article published on 19 May 2011

Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells

scientific article published on 04 October 2013

Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin

scientific article published on 03 March 2016

STAT3-targeted treatment with silibinin overcomes the acquired resistance to crizotinib in ALK-rearranged lung cancer

scientific article published on 18 October 2016

Senescence-Inflammatory Regulation of Reparative Cellular Reprogramming in Aging and Cancer.

scientific article published on 5 May 2017

Serine79-phosphorylated acetyl-CoA carboxylase, a downstream target of AMPK, localizes to the mitotic spindle poles and the cytokinesis furrow.

scientific article published on 19 April 2013

Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss.

scientific article

Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis

scientific article published on 01 January 2009

Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis

scientific article published on 08 May 2011

Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients

scientific article published on 07 June 2020

Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy

scientific article

Silibinin is a direct inhibitor of STAT3.

scientific article published on 13 April 2018

Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells

scientific article published on August 2013

Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo

scientific article published on January 2013

Stem cell property epithelial-to-mesenchymal transition is a core transcriptional network for predicting cetuximab (Erbitux™) efficacy in KRAS wild-type tumor cells

scientific article published on January 2011

Stem cell-like ALDH(bright) cellular states in EGFR-mutant non-small cell lung cancer: a novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin

scientific article published on 17 September 2013

Structure-Biological Activity Relationships of Extra-Virgin Olive Oil Phenolic Compounds: Health Properties and Bioavailability

scientific article published on 01 August 2020

Successful empirical erlotinib treatment of a mechanically ventilated patient newly diagnosed with metastatic lung adenocarcinoma

scientific article published on 24 July 2014

Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer.

scientific article published on 18 May 2016

Synchronous solid neuroendocrine breast carcinoma and abdominal lymphoma: A case report and review of the literature ⬇️

scientific article published on November 23, 2012

Synthetic lethal interaction of cetuximab with MEK1/2 inhibition in NRAS-mutant metastatic colorectal cancer

scientific article published on 12 September 2016

Targeting STAT3 with silibinin to improve cancer therapeutics

scientific article

Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells.

scientific article

Targeting human epidermal growth factor receptor 2: it is time to kill kinase death human epidermal growth factor receptor 3

scientific article published on 01 June 2007

Tentative characterization of novel phenolic compounds in extra virgin olive oils by rapid-resolution liquid chromatography coupled with mass spectrometry.

scientific article published in December 2009

Testing the efficacy of antiangiogenic agents in advanced neuroendocrine tumors

scientific article published on 01 June 2007

The Activation of the Sox2 RR2 Pluripotency Transcriptional Reporter in Human Breast Cancer Cell Lines is Dynamic and Labels Cells with Higher Tumorigenic Potential

scientific article

The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells

scientific article published on 2 April 2013

The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis.

scientific article

The acute impact of polyphenols from Hibiscus sabdariffa in metabolic homeostasis: an approach combining metabolomics and gene-expression analyses

scientific article published on 3 August 2015

The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives.

scientific article

The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer

scientific article published on January 2013

The antiobesity drug Orlistat induces cytotoxic effects, suppresses Her-2/neu (erbB-2) oncogene overexpression, and synergistically interacts with trastuzumab (Herceptin) in chemoresistant ovarian cancer cells.

scientific article published on January 2006

The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.

scientific article

The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells

scientific article published on 22 July 2016

The promiscuous and synergic molecular interaction of polyphenols in bactericidal activity: an opportunity to improve the performance of antibiotics?

scientific article published on 27 January 2015

Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment

scientific article

Transphosphorylation of kinase-dead HER3 and breast cancer progression: a new standpoint or an old concept revisited?

scientific article

Trastuzumab plus tamoxifen: anti-proliferative and molecular interactions in breast carcinoma.

scientific article

Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer Immunotherapy

scientific article published on 02 July 2020

Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation.

scientific article

Understanding the role of circulating chemokine (C-C motif) ligand 2 in patients with chronic ischemia threatening the lower extremities

scientific article published on 21 October 2014

Uptake and metabolism of olive oil polyphenols in human breast cancer cells using nano-liquid chromatography coupled to electrospray ionization–time of flight-mass spectrometry ⬇️

scientific article published on April 25, 2012

Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?

scientific article published in January 2005

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents

scientific article

Xenopatients 2.0: reprogramming the epigenetic landscapes of patient-derived cancer genomes

scientific article published on 09 January 2014

mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging

scientific article

tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO)

scientific article

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