List of works - William T Dauer

A cell autonomous torsinA requirement for cholinergic neuron survival and motor control

scientific article published on 17 August 2018

A critical evaluation of the Braak staging scheme for Parkinson's disease.

scientific article published on November 2008

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

scientific journal article

A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.

scientific article published on 22 February 2018

A novel conditional knock-in approach defines molecular and circuit effects of the DYT1 dystonia mutation

scientific article published on 14 September 2015

A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import

scientific article

Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum

scientific article

Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII

scientific journal article

Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice.

scientific article

Clinical and scientific perspectives on movement disorders: Stanley Fahn's contributions

scientific article

Contextual automated 3D analysis of subcellular organelles adapted to high-content screening

scientific article published on 16 July 2010

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

scientific article published in July 2006

Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia

scientific article published in April 2017

Current concepts on the clinical features, aetiology and management of idiopathic cervical dystonia ⬇️

scientific article published on April 1, 1998

Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice

scientific article published on 23 May 2014

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

scientific article

Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

scientific article published on 15 February 2017

Emerging common molecular pathways for primary dystonia.

scientific article published on June 2013

Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.

scientific article published on 13 September 2016

Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons

scientific article published on 8 June 2015

Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia.

scientific article

Genetic background modulates the phenotype of a mouse model of DYT1 dystonia

scientific article

Inherited dystonias: clinical features and molecular pathways

scientific article published in January 2018

Inherited isolated dystonia: clinical genetics and gene function.

scientific article

Interplay of LRRK2 with chaperone-mediated autophagy

scientific article

LRRK2 Parkinson disease mutations enhance its microtubule association.

scientific article published on 11 November 2011

Lack of alpha-synuclein does not alter apoptosis of neonatal catecholaminergic neurons.

scientific article published on October 2004

Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth.

scientific article published on 25 October 2016

Lamina-associated polypeptide 1: protein interactions and tissue-selective functions

scientific article

Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance

scientific article published on 19 September 2013

Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design.

scientific article published on 3 March 2011

Leucine-rich repeat kinase 2 for beginners: six key questions.

scientific article

Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope

scientific journal article

Magic shotgun for Parkinson's disease?

scientific article

Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation.

scholarly article

Model-based and Model-free Machine Learning Techniques for Diagnostic Prediction and Classification of Clinical Outcomes in Parkinson's Disease.

scientific article published on 8 May 2018

Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits.

scientific article

Multiplying messages LRRK beneath Parkinson disease

scientific article published in April 2014

Neurogenetic disease: genes, mechanisms, and future promise.

scientific article published in October 2014

Neuronal Nuclear Membrane Budding Occurs during a Developmental Window Modulated by Torsin Paralogs.

scientific article published on September 2016

Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins.

scientific article

Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

scientific article published on 13 August 2019

Parkinson syndrome: Heterogeneity of etiology; heterogeneity of pathogenesis?

scientific article published on 20 June 2012

Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations

scientific article

Primary dystonia: molecules and mechanisms.

scientific article published on 13 October 2009

Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons

scientific journal article

Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets.

scientific article published on March 2004

Stiff child syndrome with mutation of DYT1 gene

article

Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death ⬇️

scientific article published on September 28, 2011

The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.

scientific article published in July 2017

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

scientific article published on 10 March 2022

The WD40 domain is required for LRRK2 neurotoxicity

scientific article

The biology and pathology of the familial Parkinson's disease protein LRRK2.

scientific article published on January 2010

The nuclear envelope as a signaling node in development and disease.

scientific article

The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.

scientific article

The nuclear envelope: an intriguing focal point for neurogenetic disease

scientific article

The ons and offs of inducible transgenic technology: a review.

scientific article

The roles of kinases in familial Parkinson's disease.

scientific article published on October 2007

Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.

scientific article

TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement.

scientific article published on 27 February 2017

TorsinA dysfunction causes persistent neuronal nuclear pore defects.

scientific article published on 24 November 2017

TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration

scientific article

TorsinA restoration in a mouse model identifies a critical therapeutic window for DYT1 dystonia

scientific article published on 02 February 2021

TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models

scientific article published on 23 March 2020

alpha-Synuclein produces a long-lasting increase in neurotransmitter release

scientific journal article

alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons.

scientific article

α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.

scientific article

List of works by William T Dauer

A cell autonomous torsinA requirement for cholinergic neuron survival and motor control

A critical evaluation of the Braak staging scheme for Parkinson's disease.

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.

A novel conditional knock-in approach defines molecular and circuit effects of the DYT1 dystonia mutation

A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import

Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum

Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII

Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice.

Clinical and scientific perspectives on movement disorders: Stanley Fahn's contributions

Contextual automated 3D analysis of subcellular organelles adapted to high-content screening

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia

Current concepts on the clinical features, aetiology and management of idiopathic cervical dystonia ⬇️

Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

Emerging common molecular pathways for primary dystonia.

Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.

Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons

Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia.

Genetic background modulates the phenotype of a mouse model of DYT1 dystonia

Inherited dystonias: clinical features and molecular pathways

Inherited isolated dystonia: clinical genetics and gene function.

Interplay of LRRK2 with chaperone-mediated autophagy

LRRK2 Parkinson disease mutations enhance its microtubule association.

Lack of alpha-synuclein does not alter apoptosis of neonatal catecholaminergic neurons.

Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth.

Lamina-associated polypeptide 1: protein interactions and tissue-selective functions

Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance

Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design.

Leucine-rich repeat kinase 2 for beginners: six key questions.

Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope

Magic shotgun for Parkinson's disease?

Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation.

Model-based and Model-free Machine Learning Techniques for Diagnostic Prediction and Classification of Clinical Outcomes in Parkinson's Disease.

Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits.

Multiplying messages LRRK beneath Parkinson disease

Neurogenetic disease: genes, mechanisms, and future promise.

Neuronal Nuclear Membrane Budding Occurs during a Developmental Window Modulated by Torsin Paralogs.

Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins.

Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

Parkinson syndrome: Heterogeneity of etiology; heterogeneity of pathogenesis?

Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations

Primary dystonia: molecules and mechanisms.

Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons

Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets.

Stiff child syndrome with mutation of DYT1 gene

Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death ⬇️

The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

The WD40 domain is required for LRRK2 neurotoxicity

The biology and pathology of the familial Parkinson's disease protein LRRK2.

The nuclear envelope as a signaling node in development and disease.

The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.

The nuclear envelope: an intriguing focal point for neurogenetic disease

The ons and offs of inducible transgenic technology: a review.

The roles of kinases in familial Parkinson's disease.

Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.

TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement.

TorsinA dysfunction causes persistent neuronal nuclear pore defects.

TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration

TorsinA restoration in a mouse model identifies a critical therapeutic window for DYT1 dystonia

TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models

alpha-Synuclein produces a long-lasting increase in neurotransmitter release

alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons.

α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.