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List of works by Silvano Capitani

A network including PU.1, Vav1 and miR-142-3p sustains ATRA-induced differentiation of acute promyelocytic leukemia cells - a short report.

scientific article

Accelerated functional maturation of isolated neonatal porcine cell clusters: in vitro and in vivo results in NOD mice

scientific article published in January 2005

Accumulation of catalytically active PKC-zeta into the nucleus of HL-60 cell line plays a key role in the induction of granulocytic differentiation mediated by all-trans retinoic acid.

scientific article

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation

scientific article published on October 2014

All-trans retinoic acid shows multiple effects on the survival, proliferation and differentiation of human fetal CD34+ haemopoietic progenitor cells

scientific article published on 01 June 1995

An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction

scientific article published on December 2006

Anti-leukemic activity of dasatinib in both p53(wild-type) and p53(mutated) B malignant cells

scientific article published on 16 October 2010

Antiangiogenic Activity of the MDM2 Antagonist Nutlin-3

scientific article published on 30 November 2006

Cardiovascular disease-related miRNAs expression: potential role as biomarkers and effects of training exercise.

scientific article

Changes of Nuclear PI-PLC γ1 During Rat Liver Regeneration

scientific article published in August 1997

Changes of Nuclear Protein Kinase C Activity and Isotype Composition in PC12 Cell Proliferation and Differentiation

article

Chromatin lipids and their possible role in gene expression. A study in normal and neoplastic cells

scientific article published on January 1, 1978

Chromosome spread for confocal microscopy

scientific article published on 01 January 1999

Cisplatin cytotoxicity in organ of Corti-derived immortalized cells

scientific article published on August 2007

Conformational changes of nuclear chromatin related to phospholipid induced modifications of the template availability.

scientific article published on January 1984

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.

scientific article published on 22 May 2012

Determination of histamine in the whole blood of colon cancer patients.

scientific article published in November 2002

Diacylglycerol kinase activity in rat liver nuclei.

scientific article

Different Concentrations of Mg++ Ions Affect Nuclear Matrix Protein Distribution During Thermal Stabilization of Isolated Nuclei ⬇️

scientific article published on October 1, 1997

Effect of phosphatidylcholine vesicles on the activity of DNA polymerase-alpha

scientific article published on 01 November 1979

Effect of phospholipid vesicles on the activity of terminal transferase

scientific article published on 01 August 1979

Effect of phospholipids on transcription and ribonucleoprotein processing in isolated nuclei

scientific article published on 01 January 1986

Effects of Simulated Microgravity on the Morphology and Function of Neonatal Porcine Cell Clusters Cultured with and without Sertoli Cells

scientific article published on 01 January 2006

Enhanced resolution of specific chromosome and nuclear regions by reflectance laser scanning confocal microscopy.

scientific article published on February 1997

Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3.

scientific article published on 30 June 2009

Erythropoietin (EPO)-induced erythroid differentiation of K562 cells is accompanied by the nuclear translocation of phosphatidylinositol 3-kinase and intranuclear generation of phosphatidylinositol (3,4,5) trisphosphate ⬇️

scientific article published on January 1, 2002

Ethanolic extract from Hemidesmus indicus (Linn) displays otoprotectant activities on organotypic cultures without interfering on gentamicin uptake

scientific article

Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes

scientific article

Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line

scientific article

Expression of signal transduction proteins during the differentiation of primary human erythroblasts.

scientific article published in March 2005

Extracellular HIV-1 Tat Protein Induces a Rapid and Selective Activation of Protein Kinase C (PKC)-α, -ϵ, and -ζ Isoforms in PC12 Cells

article

Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells

scientific article published in November 1997

Extracellular HIV-1 Tat protein differentially activates the JNK and ERK/MAPK pathways in CD4 T cells

article

Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells

scientific article

Flow cytometric analysis of isolated rat liver nuclei during growth

scientific article published on 01 November 1987

Flow cytometric analysis of liposome-nuclei interaction: transfer and intranuclear release of carboxyfluorescein

scientific article published on 01 July 1986

Gentamicin-induced cytotoxicity involves protein kinase C activation, glutathione extrusion and malondialdehyde production in an immortalized cell line from the organ of corti

scientific article published on January 2003

H2B nucleohistone ? phospholipid interactions. Thermal denaturation and ultrastructural analysis

scientific article published on August 16, 1978

HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells

scientific article

HIV-1-related mechanisms of suppression of CD34+ hematopoietic progenitors

scientific article published on 01 January 1996

Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia.

scientific article published on August 2016

High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process

scientific article

Identification of PI-PLC beta 1, gamma 1, and delta 1 in rat liver: subcellular distribution and relationship to inositol lipid nuclear signalling.

scientific article published on September 1995

Immunocytochemical analysis of phosphatidylinositol-specific phospholipase C in PC12 cells: predominance of the delta isoform during neural differentiation.

scientific article published on August 1993

Impact of physical exercise in cancer survivors during and after antineoplastic treatments

scientific article published on 8 February 2018

In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness

scientific article published on 13 December 2013

In vitro growth of human fetal CD34+cells in the presence of various combinations of recombinant cytokines under serum-free culture conditions

article

Influence of physical exercise on microRNAs in skeletal muscle regeneration, aging and diseases

scientific article published on 30 March 2018

Influence of the human immunodeficiency virus type 1 Tat protein on the proliferation and differentiation of PC12 rat pheochromocytoma cells.

scientific article published in December 1993

Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status.

scientific article published on 14 July 2010

Inhibition of Ras-mediated signaling pathways in CML stem cells.

scientific article published on 12 October 2015

Inhibition of purified CD34+ hematopoietic progenitor cells by human immunodeficiency virus 1 or gp120 mediated by endogenous transforming growth factor beta 1

scientific article

Inositides in the nucleus: further developments on phospholipase C beta 1 signalling during erythroid differentiation and IGF-I induced mitogenesis.

scientific article

Inositides in the nucleus: taking stock of PLCβ1 ⬇️

scientific article published on January 1, 1998

Inositol lipid phosphorylation and breakdown in rat liver nuclei is affected by hydrocortisone blood levels

scientific article published on 01 September 1994

Inositol lipid phosphorylation in the cell nucleus

scientific article published on 01 January 1991

Intranuclear translocation of phospholipase C beta2 during HL-60 myeloid differentiation.

scientific article published in June 1997

Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation

scientific article published on March 2006

Lamin A is part of the internal nucleoskeleton of human erythroleukemia cells

scientific article published on 01 March 1999

Lipid mediated signal transduction in the cell nucleus

scientific article published on 01 January 1988

Lipid phosphorylation in isolated rat liver nuclei Synthesis of polyphosphoinositides at subnuclear level

scientific article published on 28 August 1989

Lipid-F1 nucleohistone interactions

scientific article published on 01 February 1976

Lipid-dependent nuclear signalling: morphological and functional features.

scientific article published on January 1994

Liposome-nucleus interactions. Flow cytometric study on the role of the nuclear surface

scientific article published on 01 January 1989

Low folate levels and thermolabile methylenetetrahydrofolate reductase as primary determinant of mild hyperhomocystinemia in normal and thromboembolic subjects

scientific article published on 01 July 1999

Low nanogram range quantitation of diglycerides and ceramide by high-performance liquid chromatography.

scientific article

MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway

scientific article published in October 2007

Mass spectrometry-based identification of Y745 of Vav1 as a tyrosine residue crucial in maturation of acute promyelocytic leukemia-derived cells.

scientific article

Microparticle-loaded neonatal porcine Sertoli cells for cell-based therapeutic and drug delivery system.

scientific article published on 8 August 2014

Mitogenic effects of rat Sertoli cells on adult homologous islet beta-cells: in vitro and in vivo studies

scientific article published on 01 February 2001

Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-alpha.

scientific article published on November 1998

Nuclear inositol lipid cycle and differentiation.

scientific article

Nuclear inositol lipids. Relationship between growth factor induced metabolic changes and protein kinase C activity.

scientific article published on January 1990

Nuclear lipid-dependent signal transduction in human osteosarcoma cells

scientific article published on 01 January 1997

Nuclear phosphoinositidase C during growth factor stimulation.

scientific article published on January 1993

Nuclear polyphosphoinositides during cell growth and differentiation.

scientific article published on January 1989

Nuclear protein kinases in rat liver: Evidence for increased histone H1 phosphorylating activity during liver regeneration

scientific article published on 01 July 1991

Nuclear proteome analysis reveals a role of Vav1 in modulating RNA processing during maturation of tumoral promyelocytes

article

Nuclear scaffold proteins are differently sensitive to stabilizing treatment by heat or Cu++

scientific article published on 01 February 1997

Nuclear translocation of active AKT is required for erythroid differentiation in erythropoietin treated K562 erythroleukemia cells.

scientific article

Nuclear translocation of protein kinase C-alpha and -zeta isoforms in HL-60 cells induced to differentiate along the granulocytic lineage by all-trans retinoic acid

scientific article published in June 1996

PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines

scientific article

PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors.

scientific article published on 28 March 2007

PLC-beta2 monitors the drug-induced release of differentiation blockade in tumoral myeloid precursors.

scientific article published on May 2006

PLC-β2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential.

scientific article published on 19 January 2016

Phosphatidylinositol 3-Kinase in HL-60 Nuclei Is Bound to the Nuclear Matrix and Increases During Granulocytic Differentiation

scientific article published in December 1998

Phospholipase C-β2 promotes mitosis and migration of human breast cancer-derived cells

scientific article published on 11 April 2007

Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells.

scientific article published on March 2002

RNA expression induced by cisplatin in an organ of Corti-derived immortalized cell line

scientific article

Reduced responsiveness of bone marrow megakaryocyte progenitors to platelet-derived transforming growth factor beta 1, produced in normal amount, in patients with essential thrombocythaemia

scientific article published on 01 January 1993

Response of isolated nuclei to phospholipid vesicles: analysis of chromatin sensitivity to DNase I and micrococcal nuclease

scientific article published on 01 January 1984

Response of isolated nuclei to phospholipid vesicles: analysis of the nuclear proteins after treatment with phosphatidylserine and phosphatidylcholine and comparison with heparin

scientific article published on 01 April 1984

Response of isolated nuclei to phospholipid vesicles: effect of phosphatidylserine on alpha and beta DNA polymerase activity

scientific article published on 01 May 1987

Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling.

scientific article published on 6 November 2015

Risk factors associated with relapse of eyelid basal cell carcinoma: results from a retrospective study of 142 patients.

scientific article

Role of chromatin phospholipids on template availability and ultrastructure of isolated nuclei

scientific article published on 01 January 1982

Selective modulation of the cyclin B/CDK1 and cyclin D/CDK4 complexes during in vitro human megakaryocyte development

article

Stromal derived factor-1α induces apoptosis in activated primary CD4+ T cells

scientific article published on 01 April 2000

Synergistic effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway or NUP214-ABL1 fusion protein in human Acute Lymphoblastic Leukemia

scientific article published on 3 November 2016

TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells

scientific article published on 01 August 2004

Targeting PI3K/AKT/mTOR network for treatment of leukemia.

scientific article

Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.

scientific article published on 29 July 2013

Targeting the phosphatidylinositol 3-kinase/Akt/mechanistic target of rapamycin signaling pathway in B-lineage acute lymphoblastic leukemia: An update.

scientific article published on 18 April 2018

The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy ⬇️

scientific article published on September 2013

The CD4 receptor plays essential but distinct roles in HIV-1 infection and induction of apoptosis in primary bone marrow GPIIb/IIIa+ megakaryocytes and the HEL cell line.

scientific article

The effect of sodium tetrathionate stabilization on the distribution of three nuclear matrix proteins in human K562 erythroleukemia cells.

scientific article published on July 1995

The engagement of CD4 surface antigen in the HEL haemopoietic cell line up-regulates the transforming growth factor-beta1 (TGF-beta1) promoter activity.

scientific article published on June 1997

The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells

scientific article published on July 2015

The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system.

scientific article

Three-parameter flow cytometric characterization of rat liver nuclear matrix

scientific article published on 01 April 1986

Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin.

scientific article published on July 2003

Transfer of liposome-encapsulated carboxyfluorescein to isolated nuclei

scientific article published on 01 January 1984

Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia

scientific article published on March 2015

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells

scientific article published in August 2003

Tumour necrosis factor-related apoptosis-inducing ligand sequentially activates pro-survival and pro-apoptotic pathways in SK-N-MC neuronal cells

scientific article published on 01 July 2003

Unfolding of nucleosome core induced by phosphatidylserine

scientific article published on 01 January 1987

Up-modulation of PLC-β2 reduces the number and malignancy of triple-negative breast tumor cells with a CD133+/EpCAM+ phenotype: a promising target for preventing progression of TNBC.

scientific article published on 4 September 2017

Uptake and phosphorylation of phosphatidylinositol by rat liver nuclei. Role of phosphatidylinositol transfer protein

scientific article published in May 1990

Vav promotes differentiation of human tumoral myeloid precursors.

scientific article

Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation.

scientific article

Vav1 in differentiation of tumoral promyelocytes.

scientific article

Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells

scientific article published on 7 June 2011

Vav1 is necessary for PU.1 mediated upmodulation of miR-29b in acute myeloid leukaemia-derived cells.

scientific article published on 13 March 2018

Vav1 modulates protein expression during ATRA-induced maturation of APL-derived promyelocytes: a proteomic-based analysis

scientific article

hnRNP K in PU.1-containing complexes recruited at the CD11b promoter: a distinct role in modulating granulocytic and monocytic differentiation of AML-derived cells.

scientific article

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