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List of works by Anthony B Pinkerton

6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors

scientific article published on 30 November 2010

A three-component coupling approach to cyclopentanoids.

scientific article published in November 2001

Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.

scientific article published on 12 February 2015

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis

scientific article published on 01 October 2018

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

scientific article published on 6 October 2017

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

scientific article

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones

scientific article published on 01 November 2004

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.

scientific article

Arylmethylamino steroids as antiparasitic agents

scientific article published on 17 February 2017

Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines

scientific article

Boosting NAD+ with a small molecule that activates NAMPT

scientific article published on 19 July 2019

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

scientific article published on 28 February 2017

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

scientific article

Diaryl substituted pyrazoles as potent CCR2 receptor antagonists

scientific article published on 25 October 2006

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor

scientific article

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

scientific article published on 11 November 2017

Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

scientific article

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

scientific article published on 6 May 2015

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

scientific article

Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators

scientific article published on 20 August 2019

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.

scientific article published in June 2017

Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity

scientific article published on 05 February 2014

Formation of vinyl halides via a ruthenium-catalyzed three-component coupling.

scientific article published in June 2002

Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

scientific article published on 25 January 2019

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter

scientific article

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis.

scientific article

High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase

scientific article

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

scientific article published on 14 February 2019

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

scientific article published on 19 December 2013

Imidazole-derived agonists for the neurotensin 1 receptor.

scientific article

Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6-/- Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI

scientific article published on 18 August 2018

Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11.

scientific article

Inhibitors of tissue-nonspecific alkaline phosphatase (TNAP): from hits to leads.

scientific article

ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse

scientific article published on 27 April 2016

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

scientific article

Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia

scientific article published on 12 October 2017

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

scientific article published on 7 December 2015

Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification

scientific article published on May 2015

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

scientific article

Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.

scientific article published on 12 April 2011

Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization

scientific article published in PLoS ONE

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex

scientific article

Serine-threonine kinase TAO3-mediated trafficking of endosomes containing the invadopodia scaffold TKS5α promotes cancer invasion and tumor growth

scientific article published on 07 January 2021

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

scientific article published on 10 August 2010

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

scientific article published on 23 May 2017

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

scientific article published on 20 August 2019

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