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List of works by Douglas R. Cavener

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

scientific article

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

scientific article

A rehabilitation of the genetic map of the 84B-D region in Drosophila melanogaster

scientific article

Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.

scientific article

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

scientific journal article

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

scientific article

An evolutionarily conserved palindrome in the Drosophila Gld promoter directs tissue-specific expression

scientific article

Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster

scientific article published on October 1983

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

scientific article published in June 2001

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

scientific article

Chronic granulomatous disease

scientific article published in Nature

Coevolution of the glucose dehydrogenase gene and the ejaculatory duct in the genus Drosophila

scientific article published in March 1985

Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

scientific article

Complex organization of promoter and enhancer elements regulate the tissue- and developmental stage-specific expression of the Drosophila melanogaster Gld gene

scientific article

Correction: PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice.

scientific article

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2 ⬇️

scientific article published on December 6, 2010

Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling

scientific article

Eukaryotic start and stop translation sites.

scientific article

Evolution of Developmental Regulation

scientific article published in 1989

Evolution of the expression of the Gld gene in the reproductive tract of Drosophila ⬇️

scientific article published on November 1, 1992

Evolutionary analysis of vision genes identifies potential drivers of visual differences between giraffe and okapi

scientific article published on 06 April 2017

Expansion and evolution of insect GMC oxidoreductases

scientific article

GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.

scientific article

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

scientific article published on 25 September 2009

GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis ⬇️

scientific article published on July 30, 2013

GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities.

scientific article

Genetic connectivity and population structure of African savanna elephants (Loxodonta africana) in Tanzania

scientific article published on 09 October 2020

Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.

scientific article

Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster

scientific article published in October 1980

Genomic DNA analysis of the estrogen receptor gene in breast cancer

scientific article published on 01 October 1989

Giraffe genome sequence reveals clues to its unique morphology and physiology

scientific article

Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster

scientific article

Hyperthermia Induces the ER Stress Pathway ⬇️

scientific article published on August 18, 2011

Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

scientific article published on 10 October 2013

Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2.

scientific article published in March 1994

Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2 beta.

scientific article published in May 1994

Isolation of genes encoding proteins of immunological importance

scientific article published on 01 January 1987

Isolation of the Gene Encoding the Drosophila melanogaster Homolog of the Saccharomyces cerevisiae GCN2 eIF-2α Kinase ⬇️

scientific article published on July 1, 1998

MULTIGENIC RESPONSE TO ETHANOL IN DROSOPHILA MELANOGASTER.

scientific article

Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster.

scientific article published in January 1997

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.

scientific article published on 21 May 2006

New ways of initiating translation in eukaryotes.

scientific article published on December 2001

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway ⬇️

scientific article

PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis

scientific article published in January 2006

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis

scientific article published in December 2006

PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility

scientific article

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice

scientific article

PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver

scientific journal article

PERK in beta cell biology and insulin biogenesis

scientific article published on 17 September 2010

PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation

scientific article published in December 2008

PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia.

scientific article published on 5 July 2005

PERK regulates Gq protein-coupled intracellular Ca(2+) dynamics in primary cortical neurons

scientific article published on October 2016

PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice

scientific article

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

scientific journal article

Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions

scientific article

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

scientific article

Preference for ethanol in Drosophila melanogaster associated with the alcohol dehydrogenase polymorphism ⬇️

scientific article published on September 1, 1979

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

scientific article

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

scientific article published on 10 February 2005

Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis

scientific article

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

scientific article published on 13 February 2016

Response of theG6pd and6Pgd polymorphisms inDrosophila melanogaster to dietary selection

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice

scientific article published on 23 April 2020

Seeing spots: Quantifying mother-offspring similarity and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis)

scientific article published on 15 July 2017

Seeing spots: quantifying mother-offspring similarity and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis)

scientific article published on 02 October 2018

Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3.

scientific article published on January 2009

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits ⬇️

scientific article published on August 11, 2013

The Developmental Genetic Basis of Organismal Evolution

scientific article published on 01 November 1983

The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development

scientific article published on June 1992

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

scientific article

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid

scientific article published in February 2007

The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

scientific article

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

scientific journal article

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

scientific article published on 01 June 2006

The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

scientific article published on 16 April 2014

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

scientific article published on 14 February 2018

Transgenic animal studies on the evolution of genetic regulatory circuitries.

scientific article

Translational control and the unfolded protein response

scientific article published on December 2007

Tryptophan catabolism generates autoimmune-preventive regulatory T cells

scientific article published on 10 October 2006

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

scientific article

Using spot pattern recognition to examine population biology, evolutionary ecology, sociality, and movements of giraffes: a 70-year retrospective

scientific article published in 2022

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver

scientific article

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