List of works - Nathan V Subramaniam

A 29-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Vti1-rp2) Implicated in Protein Trafficking in the Secretory Pathway ⬇️

scientific article published on August 21, 1998

A SNARE involved in protein transport through the Golgi apparatus ⬇️

scientific article published on October 23, 1997

A corn oil-based diet protects against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis.

scientific article published on 6 June 2013

A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

article

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

scientific article

A novel mutation in ferroportin implicated in iron overload

scientific article published on 28 February 2007

Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis

scientific article published in November 2011

Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo.

scientific article published on 7 January 2015

Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis.

scientific article published in April 2004

Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2.

scientific article published on 18 January 2011

Carrier-mediated thyroid hormone transport into placenta by placental transthyretin.

scientific article published on 28 April 2009

Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes.

scientific article published in August 2018

Clinical expression of C282Y homozygous HFE haemochromatosis at 14 years of age

scientific article published on 01 May 2006

Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice.

scientific article published on May 2017

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

scientific article

Defective trafficking and localization of mutated transferrin receptor 2: implications for type 3 hereditary hemochromatosis.

scientific article

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

scientific article published in February 2003

Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin

scientific article

Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading.

scientific article

Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury.

scientific article

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.

scientific article

Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet.

scientific article

Ferroportin disease due to the A77D mutation in Australia.

scientific article published in July 2005

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.

scientific article published on July 2005

Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y

scientific article published on 01 April 2002

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype.

scientific article published on 21 October 2009

Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia

scientific article published on 14 January 2015

G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective ⬇️

scientific article published on October 1, 2010

GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes.

scientific article

GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1

scientific journal article

Genetic Variants in the BMP6 Pro-Peptide May Not Cause Iron Loading and Should Be Interpreted With Caution

scientific article published on 31 August 2016

HFE gene and hemochromatosis.

scientific article

Haemochromatosis in the new millennium.

scientific article

Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia.

scientific article

Hepatic Iron Deposition Does Not Predict Extrahepatic Iron Loading in Mouse Models of Hereditary Hemochromatosis

article

Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease.

scientific article

Hepcidin regulation by HFE and TFR2: is it enough to give a hepatocyte a complex?

scientific article published on 24 July 2009

Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet.

scientific article published on June 2016

How much iron is too much?

scientific article published on 01 June 2008

Identification of ferritin receptors: their role in iron homeostasis, hepatic injury, and inflammation

scientific article published on 27 September 2009

Identification of ferroportin disease in the Indian subcontinent.

scientific article published on April 2005

In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact.

scientific article

Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: loxP system.

scientific article

Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox

scientific article published on March 2015

Increased iron stores correlate with worse disease outcomes in a mouse model of schistosomiasis infection

scientific article

Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes

scientific article published on 16 April 2018

Iron and non-alcoholic fatty liver disease

scientific article

Iron loading and oxidative stress in the Atm-/- mouse liver.

scientific article

Iron predicts tolerance in liver transplantation

scientific article published on 25 July 2012

Iron storage disease in Asia-Pacific populations: the importance of non-HFE mutations.

scientific article published on July 2013

Ironing out steatohepatitis

scientific article published on 01 January 2017

Juvenile iron overload--advances, but no answers

scientific article published on 01 October 2008

Linking hypoxia and iron homeostasis: a 'plate' full of factors

scientific article published on 04 April 2014

Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus

scientific journal article

N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex

scientific article (publication date: 10 October 1997)

Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders.

scientific article published on 04 July 2015

Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2

scientific article published on 25 November 2015

Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis

scientific article (publication date: 15 July 2002)

Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice.

scientific article published on 27 November 2013

Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease

scientific article published on 09 May 2018

Pocket-sized iron regulators: one size fits all?

scientific article

Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease.

scientific article published on May 2016

Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes

scientific article published on 01 October 2005

Purification and partial characterisation of recombinant human hepcidin

scientific article published on 18 August 2005

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

scientific article published on February 2016

Regulation of Iron Homeostasis: Is It All in the HBD?

scientific article published on 24 February 2009

Reply

scientific article published on 03 February 2017

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scientific article published on 18 December 2015

Reply

scientific article published on 15 March 2016

Reply: To PMID 25605615.

scientific article published on 23 April 2015

Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report.

scientific article published on 26 January 2018

Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum.

scientific article published on August 2000

Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis.

scientific article

Syntaxin 5 is required for copper homeostasis in Drosophila and mammals

scientific article

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

scientific article published on 18 November 2006

The Mammalian Protein (rbet1) Homologous to Yeast Bet1p Is Primarily Associated with the Pre-Golgi Intermediate Compartment and Is Involved in Vesicular Transport from the Endoplasmic Reticulum to the Golgi Apparatus ⬇️

scientific article published on December 1, 1997

The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis

scientific article published on 18 September 2006

The control of iron homeostasis: microRNAS join the party

scientific article published on 26 August 2011

The dynamics of hepcidin-ferroportin internalization and consequences of a novel ferroportin disease mutation.

scientific article

The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data.

scientific article

The liver in regulation of iron homeostasis

scientific article

The relationship between systemic iron homeostasis and erythropoiesis.

scientific article published on 2 November 2017

Transferrin receptor 1: a ferritin receptor as well?

scientific article published on 27 July 2010

Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis

scientific article published on December 2013

Transthyretin-thyroid hormone internalization by trophoblasts.

scientific article published on 2 June 2013

List of works by Nathan V Subramaniam

A 29-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Vti1-rp2) Implicated in Protein Trafficking in the Secretory Pathway ⬇️

A SNARE involved in protein transport through the Golgi apparatus ⬇️

A corn oil-based diet protects against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis.

A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

A novel mutation in ferroportin implicated in iron overload

Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis

Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo.

Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis.

Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2.

Carrier-mediated thyroid hormone transport into placenta by placental transthyretin.

Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes.

Clinical expression of C282Y homozygous HFE haemochromatosis at 14 years of age

Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice.

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

Defective trafficking and localization of mutated transferrin receptor 2: implications for type 3 hereditary hemochromatosis.

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin

Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading.

Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury.

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.

Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet.

Ferroportin disease due to the A77D mutation in Australia.

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.

Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype.

Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia

G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective ⬇️

GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes.

GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1

Genetic Variants in the BMP6 Pro-Peptide May Not Cause Iron Loading and Should Be Interpreted With Caution

HFE gene and hemochromatosis.

Haemochromatosis in the new millennium.

Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia.

Hepatic Iron Deposition Does Not Predict Extrahepatic Iron Loading in Mouse Models of Hereditary Hemochromatosis

Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease.

Hepcidin regulation by HFE and TFR2: is it enough to give a hepatocyte a complex?

Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet.

How much iron is too much?

Identification of ferritin receptors: their role in iron homeostasis, hepatic injury, and inflammation

Identification of ferroportin disease in the Indian subcontinent.

In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact.

Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: loxP system.

Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox

Increased iron stores correlate with worse disease outcomes in a mouse model of schistosomiasis infection

Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes

Iron and non-alcoholic fatty liver disease

Iron loading and oxidative stress in the Atm-/- mouse liver.

Iron predicts tolerance in liver transplantation

Iron storage disease in Asia-Pacific populations: the importance of non-HFE mutations.

Ironing out steatohepatitis

Juvenile iron overload--advances, but no answers

Linking hypoxia and iron homeostasis: a 'plate' full of factors

Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus

N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex

Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders.

Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2

Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis

Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice.

Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease

Pocket-sized iron regulators: one size fits all?

Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease.

Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes

Purification and partial characterisation of recombinant human hepcidin

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

Regulation of Iron Homeostasis: Is It All in the HBD?

Reply

Reply

Reply

Reply: To PMID 25605615.

Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report.

Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum.

Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis.

Syntaxin 5 is required for copper homeostasis in Drosophila and mammals

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

The Mammalian Protein (rbet1) Homologous to Yeast Bet1p Is Primarily Associated with the Pre-Golgi Intermediate Compartment and Is Involved in Vesicular Transport from the Endoplasmic Reticulum to the Golgi Apparatus ⬇️

The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis

The control of iron homeostasis: microRNAS join the party

The dynamics of hepcidin-ferroportin internalization and consequences of a novel ferroportin disease mutation.