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List of works by Sumit Sahni

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

scientific article published on 19 November 2016

A Unique Urinary Metabolomic Signature for the Detection of Pancreatic Ductal Adenocarcinoma

scientific article published on 31 October 2020

A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease

scientific article published on 9 August 2017

Adenosine monophosphate-activated kinase and its key role in catabolism: structure, regulation, biological activity, and pharmacological activation

scientific article

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

scientific article

Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism.

scientific article published on October 2013

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

scientific article published on 23 June 2016

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).

scientific article

Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance.

scientific article

Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.

scientific article published on 31 March 2015

Exploiting Cancer Metal Metabolism using Anti-Cancer Metal-Binding Agents.

scientific article

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia

scientific article published on June 2016

Gene of the month. AMP kinase (PRKAA1).

scientific article published on September 2014

Gene of the month: BECN1.

scientific article published on 07 May 2014

Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.

scientific article published on 15 July 2014

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1.

scientific article published on 18 April 2018

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

scientific article

Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling.

scientific article published on 14 June 2017

Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques".

scientific article published on 16 November 2016

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

scientific article published on 18 April 2016

Making a case for albumin – a highly promising drug-delivery system.

scientific article published in January 2015

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

scientific article published on 05 April 2016

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

scientific article published on 13 May 2013

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

scientific article

NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis

scientific article

Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes

scientific article published on 06 March 2018

Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron

scientific article published on 5 October 2011

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization

scientific article published on 8 December 2015

Novel serum protein biomarker panel for early diagnosis of pancreatic cancer

scientific article published in 2024

Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion

scientific article

P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration.

scientific article published on 23 September 2013

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

scientific article published in April 2015

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

scientific article published on February 2016

Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.

scientific article published on 17 February 2017

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

scientific article published on February 2016

Small Molecule KRAS Inhibitors: The Future for Targeted Pancreatic Cancer Therapy?

scientific article published on 24 May 2020

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

scientific article published on 5 May 2016

Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.

scientific article published on 19 February 2016

The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells

scientific article published on 15 September 2016

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

scientific article

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

scientific article published on 07 April 2019

The mechanistic role of chemically diverse metal ions in the induction of autophagy

scientific article published on 10 January 2017

The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

scientific article published on 15 February 2014

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

scientific article published on 3 November 2015

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

scientific article published in April 2015

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

scientific article published on 26 August 2015

The role of NDRG1 in the pathology and potential treatment of human cancers

scientific article published on 08 June 2013

The use of iron chelators in biocidal compositions: evaluation of patent, WO2014059417A1

scientific article published on 03 December 2014

Tumor stressors induce two mechanisms of intracellular p-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.

scientific article published on 5 January 2018

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