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List of works by Helfrid Hochegger

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

scientific article

Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.

scientific article

An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

scientific article

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.

scientific article published on 19 December 2011

Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle

scientific article

Bistability of mitotic entry and exit switches during open mitosis in mammalian cells.

scientific article published on 27 May 2016

Cdk activity couples epigenetic centromere inheritance to cell cycle progression.

scientific article

Cellular contractility requires ubiquitin mediated proteolysis

scientific article

Centrosome amplification in CHO and DT40 cells by inactivation of cyclin‐dependent kinases ⬇️

scientific article published on July 29, 2011

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

scientific article published on 3 July 2019

Critical roles for polymerase zeta in cellular tolerance to nitric oxide-induced DNA damage.

scientific article published in January 2006

Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B

scientific article published on 30 April 2020

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

scientific article

DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation.

scientific article

DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2.

scientific article published on 19 October 2009

DNA synthesis is required for reprogramming mediated by stem cell fusion

scientific article published on February 2013

Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage

scientific article

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1 ⬇️

scientific article

Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics.

scientific article

Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

scientific article published on 27 June 2006

Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells

scientific article published on May 2004

Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends

scientific article published on August 2005

Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells

scientific article

Interlinked bistable mechanisms generate robust mitotic transitions.

scientific article

Live imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosis

scientific article published on 11 March 2019

Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells

scientific article published in December 2005

PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit

scientific article

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

scientific article

Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase

scientific article published on 4 June 2007

Post-replication repair in DT40 cells: translesion polymerases versus recombinases

scientific article published on February 2004

PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage.

scientific article published on 22 December 2015

Proteomics of a fuzzy organelle: interphase chromatin

scientific article published on 16 February 2014

RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.

scientific article published on 22 January 2007

Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.

scientific article published in August 2004

Triggering mitosis

scientific article published on 24 October 2019

Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

scientific article published on 15 November 2018

Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage

scientific article published on October 2006

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