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List of works by Andrew M Lew

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

scientific article

A comparison of ELISA, FAST-ELISA and gel diffusion tests for detecting antibody to equine infectious anaemia virus.

scientific article published in January 1993

A microRNA expression atlas of mouse dendritic cell development.

scientific article

A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami.

scientific article

A second region recognized by the protective monoclonal antibody 5C10/66 in the precursor to the major merozoite surface antigen of Plasmodium chabaudi adami.

scientific article published in June 1990

A single buffer that universally serves both restriction digestion and loading

scientific article published on 01 May 2002

A soluble class I molecule analogous to mouse Q10 in the horse and related species

scientific article published on 01 January 1986

A soluble recombinant fusion protein of the transmembrane envelope protein of equine infectious anaemia virus for ELISA

scientific article published on June 1, 1992

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

scientific article published on 25 May 2015

Alternative protein products with different carboxyl termini from a single class I gene, H-2Kb.

scientific article published on August 1986

An inexpensive alternative to glassmilk for DNA purification

scientific article published on 01 January 1995

Analysis of T-cell receptor gamma chain expression in the thymus

scientific article published on 01 January 1987

Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model

scientific article

Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing.

scientific article published in August 2002

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

scientific article published on 31 March 2017

Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

scientific article published in Science

Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional "danger".

scientific article published in October 2005

Antigen targeted to secondary lymphoid organs via vascular cell adhesion molecule (VCAM) enhances an immune response

scientific article published on 01 May 2003

Antigen to the node: B cells go native

scientific article published on 01 April 2007

Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions

scientific article

Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice.

scientific article

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

scientific article

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-α Production

scientific article published on 01 March 2015

Bypassing luminal barriers, delivery to a gut addressin by parenteral targeting elicits local IgA responses

article

CD154+ CD4+ T-cell dependence for effective memory influenza virus-specific CD8+ T-cell responses

scientific article published on 29 April 2014

CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation

scientific article published on 01 October 2000

CD8+ T cells are associated with severe gastritis in Helicobacter pylori-infected mice in the absence of CD4+ T cells

scientific article

CTLA4Ig alters the course of autoimmune disease development in Lyn-/- mice

article

Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In Vivo

scientific article published on 01 May 2001

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

scientific article published on 13 January 2017

Characteristics of the expression of the murine soluble class I molecule (Q10)

scientific article published on 01 January 1986

Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes

scientific article published on 01 December 1986

Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responses

scientific article published in April 2009

Chimaeric protein A/protein G and protein G/alkaline phosphatase as reporter molecules

scientific article published on 01 July 1992

Class I genes and molecules: an update.

scientific article published on January 1986

Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ

scientific article

Constitutive, but not inflammatory, cross-presentation is disabled in the pancreas of young mice

scientific article published on 01 April 2002

Contribution of Thy1+ NK cells to protective IFN-γ production during Salmonella typhimurium infections

scientific article published on 23 January 2013

Control of IBMIR in neonatal porcine islet xenotransplantation in baboons

scientific article

Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways

scientific article published on 01 September 2006

DNA immunization: induction of higher avidity antibody and effect of route on T cell cytotoxicity.

scientific article published on December 1997

Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells

scientific article

Deliberately provoking local inflammation drives tumors to become their own protective vaccine site.

scientific article published on 29 September 2008

Development and preliminary testing of an inactivated equine adenovirus vaccine

scientific article published on December 1, 1979

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

scientific article published on 8 August 2006

Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking

scientific article published on 01 December 2007

Direct PCR from solid tissues without DNA extraction.

scientific article

Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.

scientific article published on 5 October 2015

Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes

scientific article published on 11 December 2013

Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction ⬇️

scientific article published on March 26, 1998

Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process

scientific article published on 27 January 2009

Expression of the human T cell receptor as defined by anti-isotypic antibodies

scientific article published on 01 February 1987

FoLT PCR: a simple PCR protocol for amplifying DNA directly from whole blood.

scientific article published in February 1993

Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse.

scientific article published on 29 April 2014

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

scientific article published on 28 August 2018

GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis.

scientific article published on 31 January 2014

Gene gun immunization in a preclinical model is enhanced by B7 targeting.

scientific article published in June 2003

Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants

article

Genetic modification of an islet tumor cell line inhibits its rejection.

scientific article published on February 1997

Genetic modification of pigs for solid organ xenotransplantation.

scientific article published on January 2011

Genetic strategies to bring islet xenotransplantation to the clinic.

scientific article published on 11 August 2016

Glomerulonephritis induced by pre-formed immune complexes containing monoclonal antibodies of defined affinity and isotype

scientific article published on 01 August 1984

Glomerulonephritis: the use of grafted hybridomas to investigate the role of epitope density, antibody affinity and antibody isotype in active serum sickness

scientific article published on 01 June 1984

Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice

scientific article published in December 2002

Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-kappaB and NFAT.

scientific article published in October 2008

H-2K molecules have two different C-termini, one of which is K-region specific

scientific article published on 01 May 1988

Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells

scientific article published on 22 October 2014

Heterogeneity, functional specialization and differentiation of monocyte-derived dendritic cells.

scientific article

Images of self: a model for tonic peripheral tolerance.

scientific article published on August 1993

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

scientific article published on 13 March 2012

Immunologic aspects of combined immunodeficiency disease in Arabian foals

scientific article published on 01 August 1980

Influence of antibody affinity on the performance of different antibody assays

scientific article published on 01 August 1984

Influence of cellular location of expressed antigen on the efficacy of DNA vaccination: cytotoxic T lymphocyte and antibody responses are suboptimal when antigen is cytoplasmic after intramuscular DNA immunization

scientific article published on 01 December 1997

Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

scientific article published on 29 October 2012

Inhibition of naïve class I-restricted T cells by altered peptide ligands

scientific article published on 01 August 1999

Inhibitory effect of lipopolysaccharide on immune response after DNA immunization is route dependent

scientific article published on 01 April 1998

Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.

scientific article published in May 2007

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells.

scientific article published on 29 July 2016

Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells

scientific article

Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes

scientific article published on 01 April 2006

Is IgG2a a good Th1 marker in mice?

scientific article published on 01 January 1998

Life and Death of Activated T Cells: How Are They Different from Naïve T Cells?

scientific article published on 13 December 2017

Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer.

scientific article

Lipidation of intact proteins produces highly immunogenic vaccine candidates

scientific article published on 05 November 2010

Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells.

scientific article

Local production of anti-CD4 antibody by transgenic allogeneic grafts affords partial protection

scientific article published on 01 September 2000

Local recall responses in the stomach involving reduced regulation and expanded help mediate vaccine-induced protection against Helicobacter pylori in mice

scientific article published in October 2010

Local secretion of a chimeric anti-CD4 antibody protects against graft rejection in the NOD mouse.

scientific article

Localization of covalent immune complexes on the epithelial side of the glomerular basement membrane in mice

scientific article published on 01 January 1984

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

scientific article

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

scientific article published on 25 August 2016

MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer

scientific article

Microplate digestion of minipreps from a single microcentrifuge tube

scientific article published on 01 May 1997

Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

article

Milk IgA responses are augmented by antigen delivery to the mucosal addressin cellular adhesion molecule 1

article

Molecular cloning and characterization of pig, cow and sheep MAdCAM-1 cDNA and the demonstration of cross-reactive epitopes amongst mammalian homologues.

scientific article published on May 2006

Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8alpha(-) splenic dendritic cells

scientific journal article

Molecular karyotyping of the rodent malarias Plasmodium chabaudi, Plasmodium berghei and Plasmodium vinckei.

scientific article published in April 1989

Monocyte-Derived Dendritic Cells Impair Early Graft Function Following Allogeneic Islet Transplantation.

scientific article published on 13 October 2016

Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation.

scientific article

Mouse loci for malaria-induced mortality and the control of parasitaemia.

scientific article published in December 1997

Mucosal immunity: overcoming the barrier for induction of proximal responses.

scientific article published in January 2004

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

scientific article published on January 2013

NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism

scientific article published on November 2006

NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge

scientific article published in September 2005

NOD mice are functionally deficient in the capacity of cross-presentation.

scientific article

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

scientific article published on 26 April 2004

Nucleic acid vaccines: tasks and tactics.

scientific article

Nucleotide sequence and comparative analysis of H-2D class 1 H-2 gene

scientific article published on 01 August 1986

Optimizing transduction of pig islet cell clusters for xenotransplantation.

scientific article published in January 2009

Overcoming the poor immunogenicity of a protein by DNA immunization as a fusion construct

scientific article published on 01 February 2001

PCR based diagnosis in the presence of 8% (v/v) blood ⬇️

scientific article published on March 11, 1991

Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ

scientific article published on 01 October 1997

Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan

scientific article published on 26 April 2016

Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

scientific article published on 05 February 2020

Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model.

scientific article

Predominant transgene expression in exocrine pancreas directed by the CMV promoter

scientific article published on 01 November 2000

Preparation of DNA from blood for polymerase chain reaction in microtiter dish

scientific article published on 01 January 1992

Prolonged allograft survival in anti-CD4 antibody transgenic mice: lack of residual helper T cells compared with other CD4-deficient mice

scientific article published on 01 July 2000

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

scientific article

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.

scientific article published in January 2013

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice.

scientific article published on 14 March 2017

Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways

scientific article published on 19 July 2010

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

scientific article

Role of regulatory T cells in xenotransplantation.

scientific article published on April 2010

SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus.

scientific article published on 21 April 2009

Secretion of a malarial histidine-rich protein (Pf HRP II) from Plasmodium falciparum-infected erythrocytes

scientific article (publication date: October 1986)

Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells

scientific article published on 05 February 2009

Selective Depletion of Cross-Presenting Dendritic Cells Enhances Islet Allograft Survival

scientific article published on 30 September 2010

Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset

scientific article

Sequence similarity between beta-cell autoantigens

scientific article published on 01 August 1995

Signals controlling alternative splicing of major histocompatibility complex H-2 class I pre-mRNA

scientific article published on 01 January 1988

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

scientific article

T cell unresponsiveness in vitro can be due to activation in vivo

scientific article published on 01 March 1998

TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death

scientific article published on 19 July 2004

Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9.

scientific article published on 16 August 2017

Targeting CD45RB alters T cell migration and delays viral clearance.

scientific article published on 16 December 2005

Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype.

scientific article published on 15 June 2011

Targeting lymphocyte Peyer's patch adhesion molecule-1: A relay approach to gut immunization

scientific article published on 01 May 2005

Targeting the Gut Vascular Endothelium Induces Gut Effector CD8 T Cell Responses Via Cross-Presentation by Dendritic Cells

article

Temporal discontinuities in progression of NOD autoimmune diabetes.

scientific article published on January 1997

The C-Type Lectin Clec12A Present on Mouse and Human Dendritic Cells Can Serve as a Target for Antigen Delivery and Enhancement of Antibody Responses

article

The Golgi apparatus in the endomembrane-rich gastric parietal cells exist as functional stable mini-stacks dispersed throughout the cytoplasm

scientific article published on December 2011

The Igh-1 sequence of the non-obese diabetic (NOD) mouse assigns it to the IgG2c isotype.

scientific article published in January 1997

The Selective Expansion and Targeted Accumulation of Bone Marrow-Derived Macrophages Drive Cardiac Vasculitis

scientific article published on 19 April 2019

The antigenicity of the chicken anaemia virus protein VP3 (Apoptin).

scientific article published in December 2001

The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functions

scientific article

The comparative efficacy of CTLA-4 and L-selectin targeted DNA vaccines in mice and sheep.

scientific article

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

scientific article published on 30 July 2008

The effect of epitope density and antibody affinity on the ELISA as analysed by monoclonal antibodies ⬇️

scientific article published on 01 August 1984

The epitope of a protective monoclonal antibody occurs in a region of microheterogeneity in Plasmodium chabaudi ⬇️

scientific article published on August 1, 1990

The gene encoding the equine soluble class I molecule is linked to the horse MHC

scientific article published on 01 January 1986

The human IgG3 hinge mediates the formation of antigen dimers that enhance humoral immune responses to DNA immunisation

article

The importance of antibody affinity in the performance of immunoassays for antibody.

scientific article published in April 1985

The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.

scientific article

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

scientific article published on 11 April 2011

The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice.

scientific article published in March 1998

The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.

scientific article

The origin of thymic CD4+CD25+ regulatory T cells and their co-stimulatory requirements are determined after elimination of recirculating peripheral CD4+ cells.

scientific article published on 20 February 2007

The polycomb repressive complex 2 governs life and death of peripheral T cells

scientific article published on 20 June 2014

The polymerase chain reaction and other amplification techniques in immunological research and diagnosis

scientific article published on 01 January 1992

The polymerase chain reaction and related techniques ⬇️

scientific article published on April 1, 1991

The regulation of the development and function of dendritic cell subsets by GM-CSF: more than a hematopoietic growth factor.

scientific article published on 14 May 2012

The role of microRNAs in lymphopoiesis.

scientific article

Thy-1+ dendritic epidermal cells express T3 antigen and the T-cell receptor gamma chain.

scientific article

Thymus-dependent and thymus-independent developmental pathways for peripheral T cell receptor-gamma delta-bearing lymphocytes.

scientific article published in June 1988

Transgenic anti-CD4 monoclonal antibody secretion by mouse segmental pancreas allografts promotes long term survival

scientific article published on 01 November 2000

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

scientific article published on 01 January 1997

Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction

scientific article published on 01 January 2000

Transplantation of xenogeneic islets: are we there yet?

scientific article published on October 2013

Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization

scientific article

Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity

scientific article published on 14 June 2012

Vaccines

Versatile co‐expression of graft‐protective proteins using 2A‐linked cassettes ⬇️

scientific article published on March 1, 2011

Whither monoclonal antibodies?

scientific article published on July 1980

Without CD4 help, CD8 rejection of pig xenografts requires CD28 costimulation but not perforin killing

scientific article published on 01 December 2001

Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation

scientific article published on 21 January 2003

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