List of works by Tuomas Knowles

A High Power-Density, Mediator-Free, Microfluidic Biophotovoltaic Device for Cyanobacterial Cells ⬇️

scientific article

A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.

scientific article published on 9 January 2018

A microfluidic strategy for the detection of membrane protein interactions

scientific article published on 03 August 2020

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

scientific article

Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions.

scientific article

Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils

scientific article published on 14 August 2020

Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials

scientific article published on 11 May 2016

Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis

scientific article published on 19 June 2019

Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform

scientific article published on 20 May 2020

Asymptotic solutions of the Oosawa model for the length distribution of biofilaments

scientific article published in May 2014

Attoliter protein nanogels from droplet nanofluidics for intracellular delivery

scientific article published on 07 February 2020

Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

scientific article published on 17 April 2020

Autoantibodies against the prion protein in individuals with PRNP mutations

scientific article published on 25 February 2020

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

scientific article published on 08 October 2019

Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation

scientific article

Biocompatible Hybrid Organic/Inorganic Microhydrogels Promote Bacterial Adherence and Eradication in Vitro and in Vivo

scientific article published on 17 February 2020

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

scientific article published on 13 July 2020

Biosensor-based label-free assays of amyloid growth

scientific article published on 11 June 2009

Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

scientific article published on 29 May 2018

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

scientific article published on 24 May 2018

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

scientific article published on 28 February 2018

Chemical and biophysical insights into the propagation of prion strains.

scientific article published on 13 October 2008

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

scientific article published on 07 May 2018

Coating and Stabilization of Liposomes by Clathrin-Inspired DNA Self-Assembly

scientific article published on 05 February 2020

Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing

article

Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation

scientific article published on 30 July 2018

Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation ⬇️

scientific article published in Physical Review Letters

Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films

scientific article published on 10 June 2021

Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly.

scientific article published on 28 June 2016

Cooperative Assembly of Hsp70 Subdomain Clusters

scientific article published on 29 May 2018

Crucial role of nonspecific interactions in amyloid nucleation. ⬇️

scientific article

DNA-Coated Functional Oil Droplets

scientific article published on 17 August 2018

Density-Gradient-Free Microfluidic Centrifugation for Analytical and Preparative Separation of Nanoparticles

scientific article published on 07 April 2014

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

article

Determination of Polypeptide Conformation with Nanoscale Resolution in Water

scientific article published on 28 June 2018

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

scientific article published on 18 February 2014

Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit

scientific article published on 15 April 2020

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

scientific article published on 10 August 2020

Direct observation of murine prion protein replication in vitro

scientific article published on 23 October 2018

Direct observation of oligomerization by single molecule fluorescence reveals a multi-step aggregation mechanism for the yeast prion protein Ure2.

scientific article published on 22 January 2018

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

scientific article published on 25 March 2019

Direct observation of the interconversion of normal and toxic forms of α-synuclein

scientific article

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

scientific article published on 26 March 2018

Dynamic microfluidic control of supramolecular peptide self-assembly

scientific article

Dynamics of heteromolecular filament formation

scientific article published on November 2016

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

scientific article published on 13 April 2020

Dynamics of protein aggregation and oligomer formation governed by secondary nucleation

scientific article

Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains

scientific article published on 10 July 2014

Electrostatic effects in filamentous protein aggregation

scientific article

Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

scientific article published on 21 April 2016

Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems

scientific article

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

scientific article published on 19 July 2019

Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection

scientific article published on 09 July 2018

Environmental Control of Amyloid Polymorphism by Modulation of Hydrodynamic Stress

scientific article published on 22 December 2020

Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.

scientific article

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

scientific article published in April 2018

Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules

scientific article published on 06 March 2019

Fabrication and characterisation of protein fibril–elastomer composites

Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.

scientific article published on 11 October 2016

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers

scientific article published on 10 August 2015

Fluctuations in the Kinetics of Linear Protein Self-Assembly.

scientific article published on 21 June 2016

Force generation by the growth of amyloid aggregates.

scientific article

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

scientific article published in Physical Review Letters

Gradient-free determination of isoelectric points of proteins on chip.

scientific article

Half a century of amyloids: past, present and future

scientific article published on 07 July 2020

Hamiltonian Dynamics of Protein Filament Formation

scientific article published on 22 January 2016

Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry

scientific article published on 29 September 2017

Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors.

scientific article

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils

article published in the Proceedings of the National Academy of Sciences of the United States of America

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy

scientific article published on 30 August 2018

Identification of on- and off-pathway oligomers in amyloid fibril formation

scientific article published on 08 June 2020

Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics

scientific article published in Scientific Reports

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42

scientific article published on 08 March 2019

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

scientific article published on 25 March 2013

Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors

scientific article published on November 2010

Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers. ⬇️

scientific article

Kinetic Analysis of Amyloid Formation

scientific article published on 01 January 2018

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

scientific article published on 01 July 2018

Kinetic constraints on self-assembly into closed supramolecular structures.

scientific article published on 25 September 2017

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

scientific article published on 28 September 2020

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

scientific article published on 16 February 2016

Kinetics of fragmentation and dissociation of two-strand protein filaments: Coarse-grained simulations and experiments. ⬇️

scientific article published in September 2016

Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation. ⬇️

scientific article published on December 2016

Label-Free Analysis of Protein Aggregation and Phase Behavior

scientific article published on 26 November 2019

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

scientific article

Lipid-Stabilized Double Emulsions Generated in Planar Microfluidic Devices

scientific article published on 26 February 2020

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

scientific article published on 8 April 2018

Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements.

scientific article published on 20 October 2017

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

article

Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2

scientific article published on 30 March 2022

Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.

scientific article published on 16 March 2016

Microfluidic Templating of Spatially Inhomogeneous Protein Microgels

scientific article published on 11 June 2020

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

scientific article published in Nature Communications

Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning

scientific article published in January 2017

Microfluidics for protein biophysics

scientific article published on 28 December 2017

Modulating the Mechanical Performance of Macroscale Fibers through Shear-Induced Alignment and Assembly of Protein Nanofibrils

scientific article published on 09 October 2019

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

scientific article published on 26 April 2017

Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation

scientific article published on 31 July 2015

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

scientific article published on 7 January 2016

Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions

scientific article published on 06 March 2020

Multidimensional protein characterisation using microfluidic post-column analysis

scientific article published on 26 June 2020

Multiphase protein microgels.

scientific article published on 19 November 2014

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

scientific article

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

scientific article

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

scientific article published on 3 July 2017

Nanomechanics of functional and pathological amyloid materials.

scientific article published on 31 July 2011

Nanoscale click-reactive scaffolds from peptide self-assembly.

scientific article

Nanoscale spatially resolved infrared spectra from single microdroplets ⬇️

scientific article

Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity

scientific article published on 3 June 2015

Oligomer Diversity during the Aggregation of the Repeat Region of Tau

scientific article published on 17 July 2018

Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function. ⬇️

scientific article

On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide

scientific article published on 10 November 2020

On the role of sidechain size and charge in the aggregation of A42 with familial mutations

article published in the Proceedings of the National Academy of Sciences of the United States of America

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.

scientific article

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

scientific article

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

scientific article published on 13 June 2018

Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

scientific article

Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.

scientific article published on 20 January 2013

Physical principles of filamentous protein self-assembly kinetics.

scientific article published on 7 February 2017

Population of nonnative states of lysozyme variants drives amyloid fibril formation

scientific article published on 29 April 2011

Position-dependent electrostatic protection against protein aggregation

scientific article published in May 2009

Preventing peptide and protein misbehavior.

scientific article published on 20 April 2015

Probing small molecule binding to amyloid fibrils

scientific article

Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation

scientific article published on 29 July 2016

Protein Aggregation in Crowded Environments

scientific article published on 01 April 2010

Protein micro- and nano-capsules for biomedical applications

scientific article published on 12 December 2013

Protein microgels from amyloid fibril networks

scientific article

Pulsed Hydrogen-Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer's Disease Mutants

scientific article published on 14 May 2021

Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay.

scientific article published on 20 December 2013

Quantifying Co-Oligomer Formation by α-Synuclein

scientific article published on 29 October 2018

Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems.

scientific article published on 4 February 2014

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms

scientific article published on 27 June 2016

Quantitative thermophoretic study of disease-related protein aggregates

scientific article published on 17 March 2016

Rapid Growth of Acetylated Aβ(16–20) into Macroscopic Crystals

scientific article published on 22 May 2018

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution

scientific article published on 20 October 2020

Real-time intrinsic fluorescence visualisation and sizing of proteins and protein complexes in microfluidic devices.

scientific article published on 16 February 2018

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

scientific article published on 17 February 2021

Relationship between prion propensity and the rates of individual molecular steps of fibril assembly

scientific article

Role of elongation and secondary pathways in S6 amyloid fibril growth.

scientific article published on May 2012

Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization.

scientific article published in June 2014

Role of intermolecular forces in defining material properties of protein nanofibrils

scientific article

SAR by kinetics for drug discovery in protein misfolding diseases

article published in the Proceedings of the National Academy of Sciences of the United States of America

Scaling behaviour and rate-determining steps in filamentous self-assembly

scientific article

Secondary nucleation in amyloid formation

scientific article published on 01 August 2018

Self-Assembly of Amyloid Fibrils That Display Active Enzymes.

scientific article published on 4 June 2014

Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces

scientific article published on 09 August 2018

Silk micrococoons for protein stabilisation and molecular encapsulation

scientific article published on 19 July 2017

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

scientific article published on 10 June 2020

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants

scientific article

Single-molecule measurements of transient biomolecular complexes through microfluidic dilution.

scientific article published on 27 June 2013

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

scientific article published on 04 November 2020

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

scientific article published on 26 July 2019

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

scientific article

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

scholarly article by Zhaoying Li published in September 2018

Spatial Propagation of Protein Polymerization

scientific article published in Physical Review Letters

Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

scientific article published in 2022

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

scientific article published on 10 August 2018

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

scientific article

Statistical Mechanics of Globular Oligomer Formation by Protein Molecules

scientific article published on 31 October 2018

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

scientific article published on 8 April 2015

Surface attachment of protein fibrils via covalent modification strategies

scientific article published on September 2010

Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform

scientific article published on 7 July 2016

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

scientific article

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

scientific article

Tetracycline nanoparticles as antibacterial and gene-silencing agents

scientific article

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.

scientific article published on 8 May 2015

The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner

scientific article published on 17 May 2006

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

scientific article published on 17 March 2020

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

scientific article published on 12 April 2016

The catalytic nature of protein aggregation

scientific article published on 01 January 2020

The length distribution of frangible biofilaments.

scientific article published on October 2015

The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation

scientific article

The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.

scientific article published on 28 February 2014

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit

scientific article published on 10 October 2017

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

scientific article published on 17 February 2020

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates

Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates.

scientific article

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion

scientific article published on 10 April 2018

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.

scientific article published on 3 November 2016

Paulina is supported by:

About Paulina

Help