List of works - Du Toit Loots

A comparison of four sputum pre-extraction preparation methods for identifying and characterising Mycobacterium tuberculosis using GCxGC-TOFMS metabolomics

scientific article published on 8 September 2012

A comparison of the cardiometabolic profile of black South Africans with suspected non-alcoholic fatty liver disease (NAFLD) and excessive alcohol use.

scientific article published on 3 December 2014

A metabolomics approach exploring the function of the ESX-3 type VII secretion system of M. smegmatis

A metabolomics approach to characterise and identify various Mycobacterium species

scientific article

A metabolomics investigation of the function of the ESX-1 gene cluster in mycobacteria.

scientific article published on 12 October 2016

Abnormal tricarboxylic acid cycle metabolites in isovaleric acidaemia.

scientific article

Acetyl-L-carnitine prevents total body hydroxyl free radical and uric acid production induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat.

scientific article

Aloe ferox leaf gel phytochemical content, antioxidant capacity, and possible health benefits

scientific article published on 28 July 2007

Altered fatty acid metabolism due to rifampicin-resistance conferring mutations in the rpoB Gene of Mycobacterium tuberculosis: mapping the potential of pharmaco-metabolomics for global health and personalized medicine

scientific article published on 11 September 2012

An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance

scientific article published on 27 January 2014

Association of alcohol consumption with specific biomarkers: a cross-sectional study in South Africa

scientific article published on March 2015

Clustering of haemostatic variables and the effect of high cashew and walnut diets on these variables in metabolic syndrome patients

scientific article published in September 2005

Diabetes, metallothionein, and zinc interactions: a review

scientific article published on January 2007

Effects of dietary onion (Allium cepa L.) in a high-fat diet streptozotocin-induced diabetes rodent model

scientific article

Elucidating the antimicrobial mechanisms of colistin sulfate on Mycobacterium tuberculosis using metabolomics

scientific article published on 08 May 2018

Experimental rodent models of type 2 diabetes: a review

scientific article published on May 2009

Fatty Acid Metabolome Extraction from Mycobacterial Cells for GC-MS Metabolomics Analysis

scientific article published on 01 January 2019

Foodstate vitamin C complex may beneficially affect haemostasis and fibrin network structure in hyperlipidaemic patients.

scientific article published in October 2004

From untargeted LC-QTOF analysis to characterisation of opines in abalone adductor muscle: Theory meets practice.

scientific article published on 24 February 2017

Glycaemic control improves fibrin network characteristics in type 2 diabetes - a purified fibrinogen model

scientific article

Glycation of fibrinogen in uncontrolled diabetic patients and the effects of glycaemic control on fibrinogen glycation

scientific article published on 15 December 2006

Identification of 19 new metabolites induced by abnormal amino acid conjugation in isovaleric acidemia

scientific article published in August 2005

Ileal and faecal digestibility of daidzein and genistein and plasma bioavailability of these isoflavones and their bioactive metabolites in the ovariectomised rat.

scientific article published in May 2009

In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract

scientific article published in March 2008

Linolenic acid and folate in wild-growing African dark leafy vegetables (morogo).

scientific article

Melatonin prevents the free radical and MADD metabolic profiles induced by antituberculosis drugs in an animal model.

scientific article

Metabolomics and Personalized Medicine

scientific article published on 29 October 2015

Metabolomics biomarkers for tuberculosis diagnostics: current status and future objectives

scientific article published on 18 January 2017

Metabolomics of colistin methanesulfonate treated Mycobacterium tuberculosis

scientific article published on 13 June 2018

New insights into the survival mechanisms of rifampicin-resistant Mycobacterium tuberculosis

scientific article

New sputum metabolite markers implicating adaptations of the host to Mycobacterium tuberculosis, and vice versa.

scientific article

Novel insights into the pharmacometabonomics of first-line tuberculosis drugs relating to metabolism, mechanism of action and drug-resistance

scientific article published on 01 November 2018

Phytochemical contents and antioxidant capacities of two Aloe greatheadii var. davyana extracts

scientific article published on 12 September 2008

Plasma polyunsaturated fatty acids and liver enzymes in HIV-infected subjects: the Prospective Urban and Rural Epidemiology (PURE) Study

scientific article

Polyphenol composition and antioxidant activity of Kei-apple (Dovyalis caffra) juice

scientific article published in February 2006

Predicting tuberculosis treatment outcome using metabolomics

scientific article published on 27 November 2017

Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice

scientific article published on 20 December 2017

Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

scientific article

Retracted: The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays

retracted article

Rosa roxburghii supplementation in a controlled feeding study increases plasma antioxidant capacity and glutathione redox state.

scientific article published on 24 March 2005

Self-reported alcohol intake is a better estimate of 5-year change in blood pressure than biochemical markers in low resource settings: the PURE study

scientific article

TB or not TB? Improving the understanding and diagnosis of tuberculosis through metabolomics

scientific article published on 19 September 2016

The altered human serum metabolome induced by a marathon

scientific article published on 03 November 2018

The application of metabolomics toward pulmonary tuberculosis research

scientific article published on 09 March 2019

The cross-tissue metabolic response of abalone (Haliotis midae) to functional hypoxia.

scientific article

The effect of glycaemic control on fibrin network structure of type 2 diabetic subjects

scientific article published on 01 November 2006

The effects of high walnut and cashew nut diets on the antioxidant status of subjects with metabolic syndrome

scientific article

The process of nutrient analysis for controlled feeding trials: a comparative study of two South African nutrient databases with chemical analysis

scientific article published on 21 November 2007

The role of metabolomics in tuberculosis treatment research

scientific article published on 17 October 2017

The unaided recovery of marathon-induced serum metabolome alterations

scientific article published on 06 July 2020

The use of functional genomics in conjunction with metabolomics for Mycobacterium tuberculosis research

scientific article published on 18 March 2014

Total Metabolome Extraction from Mycobacterial Cells for GC-MS Metabolomics Analysis

scientific article published on 01 January 2019

Uncovering the metabolic response of abalone (Haliotis midae) to environmental hypoxia through metabolomics

scientific article published on 12 March 2018

List of works by Du Toit Loots

A comparison of four sputum pre-extraction preparation methods for identifying and characterising Mycobacterium tuberculosis using GCxGC-TOFMS metabolomics

A comparison of the cardiometabolic profile of black South Africans with suspected non-alcoholic fatty liver disease (NAFLD) and excessive alcohol use.

A metabolomics approach exploring the function of the ESX-3 type VII secretion system of M. smegmatis

A metabolomics approach to characterise and identify various Mycobacterium species

A metabolomics investigation of the function of the ESX-1 gene cluster in mycobacteria.

Abnormal tricarboxylic acid cycle metabolites in isovaleric acidaemia.

Acetyl-L-carnitine prevents total body hydroxyl free radical and uric acid production induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat.

Aloe ferox leaf gel phytochemical content, antioxidant capacity, and possible health benefits

Altered fatty acid metabolism due to rifampicin-resistance conferring mutations in the rpoB Gene of Mycobacterium tuberculosis: mapping the potential of pharmaco-metabolomics for global health and personalized medicine

An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance

Association of alcohol consumption with specific biomarkers: a cross-sectional study in South Africa

Clustering of haemostatic variables and the effect of high cashew and walnut diets on these variables in metabolic syndrome patients

Diabetes, metallothionein, and zinc interactions: a review

Effects of dietary onion (Allium cepa L.) in a high-fat diet streptozotocin-induced diabetes rodent model

Elucidating the antimicrobial mechanisms of colistin sulfate on Mycobacterium tuberculosis using metabolomics

Experimental rodent models of type 2 diabetes: a review

Fatty Acid Metabolome Extraction from Mycobacterial Cells for GC-MS Metabolomics Analysis

Foodstate vitamin C complex may beneficially affect haemostasis and fibrin network structure in hyperlipidaemic patients.

From untargeted LC-QTOF analysis to characterisation of opines in abalone adductor muscle: Theory meets practice.

Glycaemic control improves fibrin network characteristics in type 2 diabetes - a purified fibrinogen model

Glycation of fibrinogen in uncontrolled diabetic patients and the effects of glycaemic control on fibrinogen glycation

Identification of 19 new metabolites induced by abnormal amino acid conjugation in isovaleric acidemia

Ileal and faecal digestibility of daidzein and genistein and plasma bioavailability of these isoflavones and their bioactive metabolites in the ovariectomised rat.

In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract

Linolenic acid and folate in wild-growing African dark leafy vegetables (morogo).

Melatonin prevents the free radical and MADD metabolic profiles induced by antituberculosis drugs in an animal model.

Metabolomics and Personalized Medicine

Metabolomics biomarkers for tuberculosis diagnostics: current status and future objectives

Metabolomics of colistin methanesulfonate treated Mycobacterium tuberculosis

New insights into the survival mechanisms of rifampicin-resistant Mycobacterium tuberculosis

New sputum metabolite markers implicating adaptations of the host to Mycobacterium tuberculosis, and vice versa.

Novel insights into the pharmacometabonomics of first-line tuberculosis drugs relating to metabolism, mechanism of action and drug-resistance

Phytochemical contents and antioxidant capacities of two Aloe greatheadii var. davyana extracts

Plasma polyunsaturated fatty acids and liver enzymes in HIV-infected subjects: the Prospective Urban and Rural Epidemiology (PURE) Study

Polyphenol composition and antioxidant activity of Kei-apple (Dovyalis caffra) juice

Predicting tuberculosis treatment outcome using metabolomics

Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice

Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.

Retracted: The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays

Rosa roxburghii supplementation in a controlled feeding study increases plasma antioxidant capacity and glutathione redox state.

Self-reported alcohol intake is a better estimate of 5-year change in blood pressure than biochemical markers in low resource settings: the PURE study

TB or not TB? Improving the understanding and diagnosis of tuberculosis through metabolomics

The altered human serum metabolome induced by a marathon

The application of metabolomics toward pulmonary tuberculosis research

The cross-tissue metabolic response of abalone (Haliotis midae) to functional hypoxia.

The effect of glycaemic control on fibrin network structure of type 2 diabetic subjects

The effects of high walnut and cashew nut diets on the antioxidant status of subjects with metabolic syndrome

The process of nutrient analysis for controlled feeding trials: a comparative study of two South African nutrient databases with chemical analysis

The role of metabolomics in tuberculosis treatment research

The unaided recovery of marathon-induced serum metabolome alterations

The use of functional genomics in conjunction with metabolomics for Mycobacterium tuberculosis research

Total Metabolome Extraction from Mycobacterial Cells for GC-MS Metabolomics Analysis

Uncovering the metabolic response of abalone (Haliotis midae) to environmental hypoxia through metabolomics

Urinary metabolite markers characterizing tuberculosis treatment failure