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List of works by George Muscat

A dynamic role for HDAC7 in MEF2-mediated muscle differentiation.

scientific article published on 8 March 2001

Beta-adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues.

scientific article published on 22 May 2009

Breast cancer prognosis predicted by nuclear receptor-coregulator networks.

scientific article published on 4 April 2014

CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells.

scientific article

Characterization of the AB (AF-1) region in the muscle-specific retinoid X receptor-gamma: evidence that the AF-1 region functions in a cell-specific manner

scientific article

Chicken ovalbumin upstream promoter-transcription factor II regulates nuclear receptor, myogenic, and metabolic gene expression in skeletal muscle cells.

scientific article

Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis.

scientific article

Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice.

scientific article

Distinct nuclear receptor expression in stroma adjacent to breast tumors.

scientific article

Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors

scientific article

Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development

scientific article

Expression profiling of skeletal muscle following acute and chronic beta2-adrenergic stimulation: implications for hypertrophy, metabolism and circadian rhythm.

scientific article

Expression vectors encoding human growth hormone (hGH) controlled by human muscle-specific promoters: prospects for regulated production of hGH delivered by myoblast transfer or intravenous injection

scientific article published on 01 August 1994

Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity.

scientific article published on September 2006

Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle ⬇️

scientific article published on January 29, 2011

Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle.

scientific article

Identification of deoxyribonucleic acid sequences that bind retinoid-X receptor-gamma with high affinity.

scientific article published on December 1994

International Union of Pharmacology. LXVI. Orphan nuclear receptors

scientific article

Mice null for sox18 are viable and display a mild coat defect

scientific article

Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease.

scientific article

Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice

scientific journal article

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF.

scientific article

Not a minute to waste

scientific article published on 01 November 2000

Nuclear Receptor Profiling of Ovarian Granulosa Cell Tumors

article

Nuclear receptor expression in human differentiated thyroid tumors.

scientific article

Nuclear receptors and epigenetic signaling: Novel regulators of glycogen metabolism in skeletal muscle ⬇️

scientific article published on July 11, 2013

Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains

scientific article

Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway.

scientific article

Orphan Nuclear Receptors and the Regulation of Nutrient Metabolism: Understanding Obesity ⬇️

scientific article published on June 1, 2012

Orphan nuclear receptors: therapeutic opportunities in skeletal muscle.

scientific article published on August 2006

PPARgamma agonists attenuate proliferation and modulate Wnt/beta-catenin signalling in melanoma cells.

scientific article published on 6 September 2008

PRMT2 and RORγ expression are associated with breast cancer survival outcomes

scientific article

Proliferin, a Prolactin/Growth Hormone-Like Peptide Represses Myogenic-Specific Transcription by the Suppression of an Essential Serum Response Factor-Like DNA-Binding Activity ⬇️

scientific article published on June 1, 1991

RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

scientific journal article

RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages

scientific article published on 26 January 2016

Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells.

scientific article published on 31 March 2011

Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors.

scientific article published on 21 August 2002

Regulation of vertebrate muscle differentiation by thyroid hormone: the role of the myoD gene family.

scientific article published on March 1995

Repression of basal transcription by vitamin D receptor: evidence for interaction of unliganded vitamin D receptor with two receptor interaction domains in RIP13delta1.

scientific article

Research resource: nuclear receptors as transcriptome: discriminant and prognostic value in breast cancer

scientific article

Retinoid-related orphan receptor alpha and the regulation of lipid homeostasis.

scientific article published on 23 June 2011

Rev-erbbeta regulates the expression of genes involved in lipid absorption in skeletal muscle cells: evidence for cross-talk between orphan nuclear receptors and myokines

scientific journal article

Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes

scientific article

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

scientific journal article

Sequence and expression of Sox-18 encoding a new HMG-box transcription factor.

scientific article

Ski overexpression in skeletal muscle modulates genetic programs that control susceptibility to diet-induced obesity and insulin signaling

scientific article published on 19 April 2012

Sox18 mutations in theragged mouse allelesragged-like andopossum

article

Structure-function analysis of the Rev-erbA and RVR ligand-binding domains reveals a large hydrophobic surface that mediates corepressor binding and a ligand cavity occupied by side chains

scientific article published on 01 May 2000

Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target

scientific article published on 01 April 1999

TRAP220 is modulated by the antineoplastic agent 6-Mercaptopurine, and mediates the activation of the NR4A subgroup of nuclear receptors.

scientific article

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

scientific journal article

The Chicken Ovalbumin Upstream Promoter-Transcription Factors Modulate Genes and Pathways Involved in Skeletal Muscle Cell Metabolism

scientific article published in Journal of Biological Chemistry

The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair

scientific article

The Nuclear Receptor, Nor-1, Induces the Physiological Responses Associated With Exercise

scientific article

The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis

scientific article published on 18 February 2016

The Ski proto-oncogene regulates body composition and suppresses lipogenesis.

scientific article published on 22 December 2009

The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18

scientific journal article

The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.

scientific article

The effects of lectin transformation on cytoplasmic polyadenylated RNA from human lymphocytes

scientific article published on 01 January 1983

The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle

scientific journal article

The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.

scientific article published on 25 April 2008

The retinoic acid and retinoid X receptors are differentially expressed during myoblast differentiation.

scientific article published on June 1994

TheSry-Related GeneSox18Maps to Distal Mouse Chromosome 2

article

Therapeutic Implications of Epigenetic Signaling in Breast Cancer.

scientific article published on 16 December 2016

Trans-activation and DNA-binding properties of the transcription factor, Sox-18

scientific journal article

Transcriptional repression by COUP-TF II is dependent on the C-terminal domain and involves the N-CoR variant, RIP13delta1.

scientific article published on November 1997

Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.

scientific article published on 20 August 2016

Transgenic muscle-specific Nor-1 expression regulates multiple pathways that effect adiposity, metabolism, and endurance

scientific article

Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors

scientific article

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