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List of works by James T Dalton

17-β estradiol protects ARPE-19 cells from oxidative stress through estrogen receptor-β.

scientific article

2-Arylthiazolidine-4-carboxylic acid amides (ATCAA) target dual pathways in cancer cells: 5'-AMP-activated protein kinase (AMPK)/mTOR and PI3K/Akt/mTOR pathways

scientific article published on October 2010

A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB

scientific article published on 01 June 2018

A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance

scientific article published on 27 November 2017

A bifunctional colchicinoid that binds to the androgen receptor

scientific article published on August 2007

A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor

scientific article published on July 2004

A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer.

scientific article published on 11 April 2010

A novel liposomal formulation of flavopiridol

scientific article published on 20 August 2008

A novel rhodamine-riboflavin conjugate probe exhibits distinct fluorescence resonance energy transfer that enables riboflavin trafficking and subcellular localization studies

scientific article published on July 2004

A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia

scientific article published on December 2009

A selective androgen receptor modulator for hormonal male contraception

scientific journal article

Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide] in rats

scientific article published on 22 April 2013

Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.

scientific article published in June 2009

Affinity labeling of the androgen receptor with nonsteroidal chemoaffinity ligands

scientific article published on 01 October 1999

Alanine aminotransferase regulation by androgens in non-hepatic tissues

scientific article published on 14 December 2011

Androgen receptor antagonists: a patent review (2008-2011).

scientific article published on May 2012

Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides

scientific article published on 3 May 2006

Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines.

scientific article published on September 2006

Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer.

scientific article

Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data

scientific article

Association of age at diagnosis and genetic mutations in patients with neuroblastoma.

scientific article

Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy

scientific article (publication date: March 2005)

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

scientific article published in Nature

Biological activity of 4-substituted methoxybenzoyl-aryl-thiazole: an active microtubule inhibitor

scientific article

Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo pharmacokinetics in mice.

scientific article published on 13 January 2011

Cancer cachexia therapy: a key weapon in the fight against cancer

scientific article published on May 2011

Cesium fluoride and tetra-n-butylammonium fluoride mediated 1,4-N-->O shift of disubstituted phenyl ring of a bicalutamide derivative

scientific article

Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens

scientific article

Characterization of the in vitro metabolism of selective androgen receptor modulator using human, rat, and dog liver enzyme preparations

scientific article

Chemistry and structural biology of androgen receptor

scientific article

Chiral nonsteroidal affinity ligands for the androgen receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring

scientific article

Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettes

scientific article published in August 2006

Chromosome arm 1q gain is an adverse prognostic factor in localized and diffuse leptomeningeal glioneuronal tumors with BRAF gene fusion and 1p deletion

scientific article published on 21 November 2018

Chronic restraint via tail immobilization of mice: effects on corticosterone levels and other physiologic indices of stress.

scientific article published in January 2002

Clear cell ependymoma: A clinicopathologic and radiographic analysis of 10 patients ⬇️

scientific article published on November 15, 2003

Clinical pharmacokinetics of 5-aminolevulinic acid in healthy volunteers and patients at high risk for recurrent bladder cancer.

scientific article published in May 2002

Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia

scientific article

Combination bortezomib and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma

scientific article published on January 2009

Comparative lipoprotein metabolism of myristate, palmitate, and stearate in normolipidemic men

scientific article published on 01 September 1996

Comparison of high-dose intermittent and low-dose continuous oral artemisinin in dogs with naturally occurring tumors.

scientific article published on 23 September 2014

Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia.

scientific article

Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin.

scientific article published on October 2010

Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes

scientific article published on May 2015

Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design

scientific article

Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables ⬇️

scientific article published on October 4, 2010

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

scientific article published on 24 October 2016

Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents

scientific article published on 7 June 2011

Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators

scientific article

Design, synthesis, and biological evaluation of stable colchicine binding site tubulin inhibitors as potential anticancer agents

scientific article

Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma

scientific article

Development and validation of a rapid and sensitive high-performance liquid chromatography-mass spectroscopy assay for determination of 17-(allylamino)-17-demethoxygeldanamycin and 17-(amino)-17-demethoxygeldanamycin in human plasma

scientific article

Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule

scientific article published on 22 April 2008

Development of selective androgen receptor modulators (SARMs).

scientific article

Discovery and mechanistic characterization of a novel selective nuclear androgen receptor exporter for the treatment of prostate cancer

scientific article

Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation

scientific article

Discovery and therapeutic promise of selective androgen receptor modulators

scientific article

Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer.

scientific article

Discovery of 4-Aryl-2-benzoyl-imidazoles as tubulin polymerization inhibitor with potent antiproliferative properties

scientific article published on 9 April 2013

Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships

scientific article published on March 2009

Discovery of Nonsteroidal Androgens ⬇️

scientific article published on March 6, 1998

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs

scientific article

Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents

scientific article

Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents

scientific article

Domain structure and DNA binding regions of beta protein from bacteriophage lambda

scientific article published on 03 July 2006

Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging

scientific article

Drug interaction potential of toremifene and N-desmethyltoremifene with multiple cytochrome P450 isoforms.

scientific article

Drug metabolism and pharmacokinetics of 4-substituted methoxybenzoyl-aryl-thiazoles

scientific article

ERβ selective agonist inhibits angiotensin-induced cardiovascular pathology in female mice

scientific article

Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators

scientific article

Effect of para halogen modification of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides on metabolism and clearance

scientific article published on 9 October 2013

Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy.

scientific article published on 9 June 2010

Effects of bladder resorption on pharmacokinetic data analysis.

scientific article published on June 1994

Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial

scientific article published on 14 March 2013

Effects of selective androgen receptor modulator (SARM) treatment in osteopenic female rats.

scientific article published in September 2009

Estrogen receptor beta selective nonsteroidal estrogens: seeking clinical indications

scientific article

Estrogen receptor-{beta}-selective ligands alleviate high-fat diet- and ovariectomy-induced obesity in mice

scientific article

Estrogen regulates histone deacetylases to prevent cardiac hypertrophy.

scientific article published on 23 October 2013

Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)

scientific article

FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma

scientific article

FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma

scientific article

Favorable effects of weak acids on negative-ion electrospray ionization mass spectrometry

scientific article

Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia

scientific article published on 26 September 2006

Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition

scientific article

GTx-822, an ER{beta}-selective agonist, protects retinal pigment epithelium (ARPE-19) from oxidative stress by activating MAPK and PI3-K pathways.

scientific article published on 16 June 2010

Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands.

scientific article

I-387, a novel antimitotic indole, displays a potent in vitro and in vivo antitumor activity with less neurotoxicity.

scientific article published on 9 September 2010

In vitro and in vivo structure-activity relationships of novel androgen receptor ligands with multiple substituents in the B-ring

scientific article

In vivo metabolism and final disposition of a novel nonsteroidal androgen in rats and dogs.

scientific article

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Infratentorial C11orf95-fused gliomas share histologic, immunophenotypic, and molecular characteristics of supratentorial RELA-fused ependymoma

scientific article published on 24 October 2020

Inhibitors of tubulin assembly identified through screening a compound library

scientific article

Interspecies differences in pharmacokinetics and metabolism of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)-propionamide: the role of N-acetyltransferase

scientific article

Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor.

scientific article

LG-10GENETIC ALTERATIONS IN UNCOMMON LOW-GRADE NEUROEPITHELIAL TUMORS: BRAF, FGFR1, AND MYB MUTATIONS OCCUR AT HIGH FREQUENCY AND ALIGN WITH MORPHOLOGY.

scientific article published on 30 May 2016

MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas ⬇️

scientific article published on November 3, 2010

Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls

scientific article

Medetomidine Analogs as α2-Adrenergic Ligands. 3. Synthesis and Biological Evaluation of a New Series of Medetomidine Analogs and Their Potential Binding Interactions with α2-Adrenoceptors Involving a “Methyl Pocket” ⬇️

scientific article published on September 12, 1997

Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine.

scientific article

Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature

scientific article published in September 2004

MicroRNAs are mediators of androgen action in prostate and muscle

scientific article (publication date: 2010)

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

scientific article published on 16 June 2018

Molecular target characterization and antimyeloma activity of the novel, insulin-like growth factor 1 receptor inhibitor, GTx-134.

scientific article published on June 2011

Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies

scientific article published on January 2011

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

scientific article (publication date: 25 June 2009)

Nonsteroidal selective androgen receptor modulators enhance female sexual motivation.

scientific article

Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

scientific article published on 4 October 2017

Novel nonsteroidal ligands with high binding affinity and potent functional activity for the androgen receptor.

scientific article published on August 2002

Novel tubulin polymerization inhibitors overcome multidrug resistance and reduce melanoma lung metastasis

scientific article published on 13 March 2012

Ockham's razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5alpha-reductase?

scientific article

Orally Bioavailable Tubulin Antagonists for Paclitaxel-Refractory Cancer ⬇️

scientific article published on July 4, 2012

Pediatric Supratentorial Ependymoma: Surgical, Clinical, and Molecular Analysis

scientific article published on 01 July 2019

Pharmacodynamics of selective androgen receptor modulators

scientific article

Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024(Enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin.

scientific article published on 22 April 2016

Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability.

scientific article

Pharmacokinetics and metabolism of a selective androgen receptor modulator in rats: implication of molecular properties and intensive metabolic profile to investigate ideal pharmacokinetic characteristics of a propanamide in preclinical study

scientific article

Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands

scientific article

Pharmacokinetics, biodistribution and metabolism of a novel selective androgen receptor modulator designed for prostate cancer imaging.

scientific article

Pharmacokinetics, pharmacodynamics and metabolism of a novel anticancer agent for prostate cancer

scientific article published on 20 April 2012

Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue

scientific article published on 12 October 2016

Pharmacology, pharmacokinetics, and metabolism of acetothiolutamide, a novel nonsteroidal agonist for the androgen receptor.

scientific article

Polar spongioblastoma of the spinal cord: a case report

scientific article published on 1 January 2006

Population pharmacokinetics of humanized monoclonal antibody HuCC49deltaCH2 and murine antibody CC49 in colorectal cancer patients

scientific article published on 01 February 2007

Pre-systemic metabolism prevents in vivo antikinetoplastid activity of N1,N4-substituted 3,5-dinitro sulfanilamide, GB-II-150

scientific article published on 28 March 2006

Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception

scientific article

Preclinical characterization of a novel diphenyl benzamide selective ERα agonist for hormone therapy in prostate cancer

scientific article

Preclinical pharmacology of a nonsteroidal ligand for androgen receptor-mediated imaging of prostate cancer.

scientific article published on 24 January 2006

Recombinant expression and purification of human androgen receptor in a baculovirus system.

scientific article published on June 2001

Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.

scientific article

Role and pharmacologic significance of cytochrome P-450 2D6 in oxidative metabolism of toremifene and tamoxifen

scientific article published on 14 September 2012

Role of nuclear receptors in lipid dysfunction and obesity-related diseases.

scientific article

SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: a novel class of cytotoxic agents for prostate cancer.

scientific article published on September 2005

Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats

scientific article

Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats

scientific article

Selective androgen receptor modulators (SARMs) negatively regulate triple-negative breast cancer growth and epithelial:mesenchymal stem cell signaling

scientific article

Selective androgen receptor modulators as improved androgen therapy for advanced breast cancer.

scientific article

Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.

scientific article

Selective androgen receptor modulators for the treatment of late onset male hypogonadism

scientific article published on March 2014

Selective androgen receptor modulators in preclinical and clinical development

scientific article

Selective estrogen receptor alpha agonist GTx-758 decreases testosterone with reduced side effects of androgen deprivation therapy in men with advanced prostate cancer

scientific article

Standard pentostatin dose reductions in renal insufficiency are not adequate: selected patients with steroid-refractory acute graft-versus-host disease

scientific article published on August 2013

Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways.

scientific article published on 18 September 2008

Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth

scientific article published on 30 August 2013

Structural basis for accommodation of nonsteroidal ligands in the androgen receptor

scientific article

Structural basis for antagonism and resistance of bicalutamide in prostate cancer

scientific article

Structural determinants of P-glycoprotein-mediated transport of glucocorticoids

scientific article published on November 2003

Structure and evolution of double minutes in diagnosis and relapse brain tumors

scientific article published on 28 September 2018

Structure determination of chiral sulfoxide in diastereomeric bicalutamide derivatives.

scientific article published in June 2009

Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma

scientific article published on March 2007

Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)

scientific article

Synthesis and antiproliferative activity of 2-aryl-4-oxo-thiazolidin-3-yl-amides for prostate cancer

scientific article published on November 2004

Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma.

scientific article

Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization

scientific article

Synthesis and antiproliferative activity of thiazolidine analogs for melanoma.

scientific article

Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer

scientific article published on October 2004

Synthesis of irreversibly binding bicalutamide analogs for imaging studies

scientific article

Synthesis of oxazolidinedione derived bicalutamide analogs.

scientific article

Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides

scientific article published on August 2006

Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents.

scientific article published on 11 December 2009

TERT Promoter Mutations Are Predictive of Aggressive Clinical Behavior in Patients with Spitzoid Melanocytic Neoplasms

scientific article published on 10 June 2015

TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia

scientific article published on 02 December 2013

The genomic landscape of childhood and adolescent melanoma.

scientific article published on 30 September 2014

The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing

scientific article published on 19 February 2016

The long and winding road for selective androgen receptor modulators.

scientific article published on 16 June 2017

The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulators

scientific article

The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial.

scientific article

Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery

scientific article

Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation

scientific article

Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy.

scientific article

Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets

scientific article

Use of intravenous valproate in three pediatric patients with nonconvulsive or convulsive status epilepticus

scientific article published on 01 May 1999

YAP1-fusions in pediatric NF2-wildtype meningioma

scientific article published on 16 November 2019

β-LGND2, an ERβ selective agonist, inhibits pathologic retinal neovascularization

scientific article published on 31 July 2012

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