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List of works by Michael S Seaman

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo

scientific article published on 30 October 2015

A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1

scientific article

A method for identification of HIV gp140 binding memory B cells in human blood

scientific article

A mouse model for HIV-1 entry

scientific article

A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection

scientific article published on 16 April 2018

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

scientific article

Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

scientific article

Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals

scientific article

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

scientific article

Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike

scientific article

Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.

scientific article

Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency

scientific article published on June 2016

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.

scientific article

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

scientific article published on 21 May 2019

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

scientific article

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

scientific article

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

scientific article published on 24 April 2014

Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice

scientific article

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

scientific article published on September 2017

Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies

scientific article published on October 2003

Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

scientific article

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

scientific article published in Nature

Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost

scientific article published on 8 April 2015

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

scientific article

Correction for Hraber et al., "Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments".

scientific article

Correction for Kibler et al., "Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC"

scientific article published on 15 October 2019

Correction: Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization

scientific article published on 25 September 2017

Corrigendum to: Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes [Virology 475 (2015) 37–45]

article

Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

scientific article published on 23 March 2016

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

scientific article published on 01 July 2019

Dominant CD8+ T-lymphocyte responses suppress expansion of vaccine-elicited subdominant T lymphocytes in rhesus monkeys challenged with pathogenic simian-human immunodeficiency virus

scientific article published on 29 July 2009

Early antibody therapy can induce long-lasting immunity to SHIV

scientific article

Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants

scientific article

Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape

scientific article

Expansion after epitope peptide exposure in vitro predicts cytotoxic T lymphocyte epitope dominance hierarchy in lymphocytes of vaccinated mamu-a*01+ rhesus monkeys

scientific article published on 01 May 2006

Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization

scientific article

Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site

scientific article published on 8 March 2018

First-in-Human Randomized Controlled Trial of Mosaic HIV-1 Immunogens Delivered via a Modified Vaccinia Ankara Vector

scientific article published on 13 April 2018

Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies

scientific article

Global panel of HIV-1 Env reference strains for standardized assessments of vaccine-elicited neutralizing antibodies

scientific article

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

article

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

scientific article published on 01 August 2019

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

scientific article

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

scientific article

HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes

scientific article published on 18 January 2012

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

scientific article published on 16 September 2013

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.

scientific article

HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells

scientific article published on 11 April 2019

HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Speci

scientific article published on 8 February 2017

Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates

scientific article published on 3 June 2015

Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys

scientific article

Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies

scientific article published on 24 February 2020

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

scientific article published on November 2016

Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

scientific article

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

scientific article

Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys.

scientific article published on 23 January 2009

Impact of clade, geography, and age of the epidemic on HIV-1 neutralization by antibodies

scientific article

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

scientific article published on 12 August 2015

Increased frequencies of CD8+CD57+ T cells are associated with antibody neutralization breadth against HIV in viraemic controllers

scientific article published on 9 December 2016

Increasing the potency and breadth of an HIV antibody by using structure-based rational design

scientific article

Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques

scientific article published on 29 February 2024

Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes

scientific article published on 22 November 2014

International seroepidemiology of adenovirus serotypes 5, 26, 35, and 48 in pediatric and adult populations

scientific article

Intra-spike crosslinking overcomes antibody evasion by HIV-1

scientific article

Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants

scientific article (publication date: 2012)

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

scientific article

Neutralization tiers of HIV-1.

scientific article published on 20 December 2017

Neutralizing Antibody Responses following Long-Term Vaccination with HIV-1 Env gp140 in Guinea Pigs

scientific article published on 11 April 2018

Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo

scientific article

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

scientific article

PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.

scientific article published on 15 February 2012

Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.

scientific article published on 21 November 2016

Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments

scientific article

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

scientific article published on September 2010

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

scientific article published on January 2017

Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens

scientific article published on 10 February 2016

Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections.

scientific article published on 5 March 2018

Predicting the broadly neutralizing antibody susceptibility of the HIV reservoir

scientific article published on 05 September 2019

Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials

scientific article published on 4 December 2017

Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys

scientific article published in May 2006

Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

scientific article

Priming with a potent HIV-1 DNA vaccine frames the quality of immune responses prior to a poxvirus and protein boost

article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences

scientific article published on 5 February 2016

Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.

scientific article published on 24 September 2008

Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail.

scientific article published on September 2017

Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys ⬇️

scientific article published on 24 October 2013

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

scientific article (publication date: 13 August 2010)

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

scientific article

Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines.

scientific article published on November 2004

Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117

article

Replication-competent NYVAC-KC yields improved immunogenicity to HIV-1 antigens in rhesus macaques, compared to non-replicating NYVAC

article

Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates

scientific article

Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies

scientific article

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody

scientific article published on 30 January 2020

Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys

scientific article

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

scientific article

Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env

scientific article published on 24 November 2021

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

scientific article

Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates

scientific article published on 04 June 2021

Subsets of memory cytotoxic T lymphocytes elicited by vaccination influence the efficiency of secondary expansion in vivo

scientific article

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy.

scientific article

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

scientific article

Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies

scientific article

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

scientific article published on 4 January 2012

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

scientific article published on 08 April 2015

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