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List of works by Amancio Carnero

19P Comparative effectiveness analysis of HSP90 inhibitors in non-small cell lung cancer

20P Context-dependent role of FGFR4 in lung tumorogenesis

3D and organoid culture in research: physiology, hereditary genetic diseases and cancer

scientific article published on 01 April 2022

A dual-color fluorescence-based platform to identify selective inhibitors of Akt signaling

scientific article

A genetic view of laryngeal cancer heterogeneity

scientific article published on 03 March 2016

A proinflammatory cytokine inhibits p53 tumor suppressor activity

scientific article

Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation

scientific article published in August 2004

Activation of intracellular kinases in Xenopus oocytes by p21ras and phospholipases: a comparative study

scientific article published on February 1995

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

scientific article

Acylphosphatase synergizes with progesterone during maturation of Xenopus laevis oocytes

scientific article published in August 1993

Adding more content to screening: reactivation of FOXO as a therapeutic strategy

scientific article published on October 2009

An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays

scientific article

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article

Association between the miRNA signatures in plasma and bronchoalveolar fluid in respiratory pathologies.

scientific article published on January 2012

Battling cancer on many fronts. Meeting on New Battlefields in Human Cancer--Attacking in Many Fronts

scientific article published on September 2008

Between bench and bed side: PI3K inhibitors

scientific article published on June 2010

Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells

scientific article published on 26 October 2020

Bypassing cellular senescence by genetic screening tools

scientific article published on June 2010

CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.

scientific article

Cancer, senescence, and aging: translation from basic research to clinics

scientific article published on 20 October 2011

Cellular Senescence as a Target in Cancer Control

Cellular senescence as a target in cancer control

scientific article published on 30 December 2010

Cellular senescence induced by p53-ras cooperation is independent of p21waf1 in murine embryo fibroblasts

scientific article

Characterization of the p53 response to oncogene-induced senescence

scientific article

Chemical genetic analysis of FOXO nuclear-cytoplasmic shuttling by using image-based cell screening

scientific article

Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases

scientific article published on 18 August 2009

Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation

scientific article

Combined MEK and PI3K/p110β Inhibition as a Novel Targeted Therapy for Malignant Mesothelioma Displaying Sarcomatoid Features

scientific article published on 07 January 2020

Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia

scientific article

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity

scientific article published in May 2005

Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer.

scientific article published on 26 October 2017

Correction: Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src

scientific article published on November 2016

DNA methylation signatures identify biologically distinct thyroid cancer subtypes.

scientific article published on 10 May 2013

Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src

scientific article published on 20 April 2016

Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain

scientific article

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Disruptive chemicals, senescence and immortality

scientific article

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

scientific article published on 19 May 2011

Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness

scientific article published on 11 January 2020

Dr. Jekyll and Mr. Hyde: MAP17's up-regulation, a crosspoint in cancer and inflammatory diseases.

scientific article published on 12 April 2018

EMX homeobox genes regulate microphthalmia and alter melanocyte biology

scientific article published on 27 September 2005

Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA.

scientific article published on 20 October 2015

Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1).

scientific article published on 22 August 2016

Epigenetic mechanisms in senescence, immortalisation and cancer

scientific article published on 16 September 2010

Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models

scientific article

Expression of CYP3A4 as a predictor of response to chemotherapy in peripheral T-cell lymphomas

scientific article published on 18 July 2007

Extreme sensitivity to Yondelis® (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53

scientific article published on 01 February 2007

FGFR1 Cooperates with EGFR in Lung Cancer Oncogenesis, and Their Combined Inhibition Shows Improved Efficacy

scientific article published on 09 January 2019

FGFR4 increases EGFR oncogenic signaling in lung adenocarcinoma, and their combined inhibition is highly effective

scientific article published on 08 February 2019

Gemcitabine plus sirolimus for relapsed and progressing osteosarcoma patients after standard chemotherapy: a multicenter, single-arm phase II trial of Spanish Group for Research on Sarcoma (GEIS).

scientific article

Gene expression profile predictive of response to chemotherapy in metastatic colorectal cancer.

scientific article published on March 2015

Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression.

scientific article

Genetic modelling of the PTEN/AKT pathway in cancer research

scientific article published on October 2008

Genetic modification of hypoxia signaling in animal models and its effect on cancer

scientific article

Genome-Wide miRNA Screening for Genes Bypassing Oncogene-Induced Senescence

scientific article published in January 2017

High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer.

scientific article published on 13 July 2015

High throughput screening in drug discovery.

scientific article published in July 2006

Histology-dependent prognostic role of pERK and p53 protein levels in early-stage non-small cell lung cancer.

scientific article

Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells

scientific article published on 8 March 2010

IL-11 and CCL-1: Novel Protein Diagnostic Biomarkers of Lung Adenocarcinoma in Bronchoalveolar Lavage Fluid (BALF).

scientific article published on 11 August 2016

Identification of oxidative stress related proteins as biomarkers for lung cancer and chronic obstructive pulmonary disease in bronchoalveolar lavage.

scientific article

Identification of proteomic signatures associated with lung cancer and COPD.

scientific article

Identification of transcripts specific for physiological gene activation by platelet-derived growth factor (PDGF)-B in intact brain tissue

scientific article published on July 2005

Immortalization of primary human prostate epithelial cells by c-Myc.

scientific article

Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer

scientific article published on 15 July 2016

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.

scientific article published on 22 July 2017

Influence of (hydroxymethyl)pyridine and pyridine-carboxylic acids, in trans-position to the isopropylamine and amine ligands, on the cytotoxicity of platinum complexes

scientific article

Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(II) anticancer complexes

scientific article

Inhibiting PI3K as a therapeutic strategy against cancer

scientific article published on September 2009

Inhibition of HSP90 molecular chaperones: moving into the clinic

scientific article

Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria

scientific article published on October 2005

Isolation of an Intermediate in the Platination ofp-Nitroacetophenone 4-Methylthiosemicarbazone: Potential Application as an Antitumor Drug

Large scale genetic screen identifies MAP17 as protein bypassing TNF-induced growth arrest.

scientific article

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

scientific article

Levels of p27(kip1) determine Aplidin sensitivity

scientific article published on April 2007

Loss of MYBBP1A Induces Cancer Stem Cell Activity in Renal Cancer

scientific article published on 18 February 2019

Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors.

scientific article

Loss-of-function genetic screening identifies a cluster of ribosomal proteins regulating p53 function

scientific article published on 29 May 2008

MAP17 (PDZK1IP1) and pH2AX are potential predictive biomarkers for rectal cancer treatment efficacy

MAP17 (PDZKIP1) Expression Determines Sensitivity to the Proteasomal Inhibitor Bortezomib by Preventing Cytoprotective Autophagy and NFκB Activation in Breast Cancer

scientific article

MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer.

scientific article published in May 2015

MAP17 and SGLT1 protein expression levels as prognostic markers for cervical tumor patient survival

scientific article

MAP17 and the double-edged sword of ROS.

scientific article published on 23 March 2012

MAP17 as Biomarker for Cancer Treatment

MAP17 enhances the malignant behavior of tumor cells through ROS increase

scientific article

MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation

scientific article published on 3 August 2007

MAP17 overexpression is a common characteristic of carcinomas

scientific article

MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma

scientific article published on 17 August 2018

MAP17, a ROS-dependent oncogene ⬇️

scientific article published on September 6, 2012

MaRX: an approach to genetics in mammalian cells.

scientific article

Markers of Cellular Senescence ⬇️

scientific article published on January 1, 2013

Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt.

scientific article published in August 2005

MiR-107 and miR-99a-3p predict chemotherapy response in patients with advanced colorectal cancer

scientific article

Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer

MicroRNA clusters: dysregulation in lung adenocarcinoma and COPD.

scientific article published on 17 April 2014

MicroRNA-dependent regulation of transcription in non-small cell lung cancer

scientific article

Microinjection of acylphosphatase blocks Xenopus laevis oocytes maturation induced by ras-p21.

scientific article published in July 1993

Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines

scientific article

Modulation of cellular chemoresistance in keratinocytes by activation of different oncogenes

Mouse models to decipher the PI3K signaling network in human cancer

scientific article published on June 2009

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate

scientific article published on 19 March 2007

NAMPT Is a Potent Oncogene in Colon Cancer Progression that Modulates Cancer Stem Cell Properties and Resistance to Therapy through Sirt1 and PARP.

scientific article published on 4 December 2017

NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis

scientific article published on 28 August 2017

NUMB and NUMBL differences in gene regulation.

scientific article

New trans-platinum drugs with phosphines and amines as carrier ligands induce apoptosis in tumor cells resistant to cisplatin

scientific article published on 4 April 2007

Non-neutral role of replicative senescence in tissue homeostasis and tumorigenesis

scientific article published in October 2004

Novel inhibitors of the PI3K family

scientific article published on September 2009

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy.

scientific article published on 23 August 2016

Overexpression of cyclin D1 inhibits TNF-induced growth arrest

scientific article published in June 2003

Oxidation of anticancer Pt(II) complexes with monodentate phosphane ligands: towards stable but active Pt(IV) prodrugs

scientific article published on May 2013

PDGFRα/β and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome

scientific article

PPP1CA contributes to the senescence program induced by oncogenic Ras.

scientific article published on 19 January 2008

PTEN, more than the AKT pathway

scientific article published on 6 March 2007

Phospholipase-induced maturation of Xenopus laevis oocytes: mitogenic activity of generated metabolites

scientific article published in August 1993

Phosphorylation of gH2AX as a novel prognostic biomarker for laryngoesophageal dysfunction-free survival

scientific article published on 04 May 2016

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

scientific article published on 3 November 2010

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities ⬇️

scientific article published on 05 October 2012

Platinum(IV) Complexes of 3- and 4-Picolinic Acids Containing Ammine or Isopropylamine Ligands - Synthesis, Characterization, X-ray Structures, and Evaluation of Their Cytotoxic Activity against Cancer Cell Lines

Progesterone but not ras requires MPF for in vivo activation of MAPK and S6 KII: MAPK is an essential conexion point of both signaling pathways

scientific article

Prognostic relevance of Src activation in stage II-III colon cancer

scientific article published on 7 June 2017

Prognostic relevance of estrogen receptor-α Ser167 phosphorylation in stage II-III colon cancer patients.

scientific article published on 2 September 2014

Proteomic biomarkers in lung cancer

scientific article published on 20 April 2013

Role of Mitochondria in Cancer Stem Cell Resistance

scientific article published on 15 July 2020

Role of the Hypoxic-Secretome in Seed and Soil Metastatic Preparation

scientific article published in 2022

Roscovitine targets, protein kinases and pyridoxal kinase

scientific journal article

S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

scientific article published on 19 August 2008

Senescence in Oncogenesis: From Molecular Mechanisms to Therapeutic Opportunities

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation

Spinophilin loss contributes to tumorigenesis in vivo

scientific article published on 15 June 2011

Spinophilin loss correlates with poor patient prognosis in advanced stages of colon carcinoma.

scientific article published on 31 May 2013

Structure-activity relationship of new trans-platinum(II) and (IV) complexes with cyclohexylamine. Interference with cell cycle progression and induction of cell death

scientific article published on 30 November 2006

Subcellular localisation of pMEK has a different prognosis in locally advanced head and neck cancer treated with concomitant radiochemotherapy

scientific article

Synthesis, Reactivity Studies, and Cytotoxicity of Two trans-Iodidoplatinum(II) Complexes. Does Photoactivation Work?

Targeting Cancer Stem Cells to Overcome Therapy Resistance in Ovarian Cancer

scientific article published on 04 June 2020

Targeting of p53-transcriptional dysfunction by conditionally replicating adenovirus is not limited by p53-homologues

scientific article

Targeting the cell cycle for cancer therapy

scientific article

The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB.

scientific article published on 2 February 2017

The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma

scientific article published on 21 September 2016

The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction.

scientific article published on 5 February 2018

The PIM family of serine/threonine kinases in cancer

scientific article published on 10 April 2013

The PKB/AKT pathway in cancer

scientific article published on January 2010

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models

scientific article

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

scientific article published on May 2008

The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras

scientific article published on 30 September 2010

The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness

scientific article published on 20 January 2020

The cancer stem-cell signaling network and resistance to therapy

scientific article

The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment

scientific article published on 6 October 2017

The essential role of PIM kinases in sarcoma growth and bone invasion

scientific article published on 22 May 2012

The hypoxic microenvironment: A determinant of cancer stem cell evolution

scientific article

The preparation and characterization of trans-platinum(IV) complexes with unusually high cytotoxicity

scientific article published on 8 October 2010

The role of PIM1/PIM2 kinases in tumors of the male reproductive system

scientific article (publication date: 30 November 2016)

The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine

scientific article published on October 2009

The second generation of iodido complexes: trans-[PtI2(amine)(amine')] bearing different aliphatic amines

scientific article published on 28 April 2013

Therapeutic targeting of replicative immortality

scientific article

Trans-platinum(II) complexes with cyclohexylamine as expectator ligand induce necrosis in tumour cells by inhibiting DNA synthesis and RNA transcription.

scientific article published on August 2007

Transcriptional signature of Ecteinascidin 743 (Yondelis, Trabectedin) in human sarcoma cells explanted from chemo-naive patients.

scientific article

Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment

article by Sandra Muñoz-Galván et al published 10 October 2018 in Oncogene

Understanding FOXO, New Views on Old Transcription Factors

scientific article published on 01 March 2010

Using cells devoid of RAS proteins as tools for drug discovery

scientific article

Using multiplexed regulation of luciferase activity and GFP translocation to screen for FOXO modulators

scientific article

Wortmannin, an inhibitor of phosphatidyl‐inositol 3‐kinase, induces oocyte maturation through a MPF‐MAPK‐dependent pathway ⬇️

scientific article published on January 30, 1998

c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer

scientific article published on 11 June 2019

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

scientific article published on 01 March 2000

p38α limits the contribution of MAP17 to cancer progression in breast tumors

scientific article published on 23 January 2012

ras-p21 activates phospholipase D and A2, but not phospholipase C or PKC, in Xenopus laevis oocytes

scientific article published on April 1994

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