List of works - Hisashi Arase

A Di-leucine Signal in the Ubiquitin Moiety

scientific article published in Journal of Biological Chemistry

A motif in LILRB2 critical for Angptl2 binding and activation.

scientific article

A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor alpha (PILRalpha) abrogates PILRalpha-dependent viral entry and reduces pathogenesis

scientific article

Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor

scientific journal article

Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility

scientific article published on 24 February 2014

Bimodal regulation of T cell-mediated immune responses by TIM-4

scientific article published on 26 March 2008

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.

scientific article

Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors.

scientific article published on 30 January 2008

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

journal article published in 2018

Cell components required for deletion of an autoreactive T cell repertoire

scientific article published on 01 May 1990

Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function

scientific article

Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5

scientific article published in 2023

Crucial role of Jak3 in negative selection of self-reactive T cells.

scientific article published on January 1997

Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex

scientific article (publication date: 6 July 2001)

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.

scientific article published in December 1995

Differential contribution of the FcR gamma chain to the surface expression of the T cell receptor among T cells localized in epithelia: analysis of FcR gamma-deficient mice

scientific article published on 01 July 1995

Differential effects on cell fusion activity of mutations in herpes simplex virus 1 glycoprotein B (gB) dependent on whether a gD receptor or a gB receptor is overexpressed

scientific article

Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

scientific article published on 11 April 2002

Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.

scientific article published on 2 February 2006

Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration

scientific article published on 22 June 2015

Engineering large viral DNA genomes using the CRISPR-Cas9 system

scientific article published on September 2014

Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.

scientific article

Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations

scientific article published on 04 June 2015

Functional studies on MEL-14+ and MEL-14− T cells in peripheral lymphoid tissues ⬇️

scientific article published on April 1, 1994

Genotype and phenotype analysis of patients with pediatric cutaneous mastocytosis, especially wild-type KIT patients

scientific article published on 20 February 2020

HSV-1 infection through inhibitory receptor, PILRalpha.

scientific article published on June 2008

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

article published in the Proceedings of the National Academy of Sciences of the United States of America

Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages

scientific article

Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells

scientific article published on 9 August 2005

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

scientific article

Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis.

scientific article

Invariant chain p41 mediates production of soluble MHC class II molecules

scientific article published on 23 December 2018

Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).

scientific article published on 7 June 2004

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration

scientific article published in Nature

Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection

scientific article published on 30 March 2009

Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation.

scientific article

Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2

scientific article (publication date: 25 April 2016)

Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors

scientific article

Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway

scientific article

Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα.

scientific article published on 3 February 2016

NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules

scientific article

Negative regulation of DSS-induced experimental colitis by PILRα.

scientific article published on 20 February 2015

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation

scientific article published on 11 November 2012

Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1 ⬇️

scientific article published on October 14, 2010

Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.

scientific article

PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues.

scientific article

Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system

scientific article

Preferential requirement of CD3 zeta-mediated signals for development of immature rather than mature thymocytes.

scientific article

Reconstitution of lymphoid tissues under the influence of a subclinical level of graft versus host reaction induced by bone marrow T cells or splenic T cell subsets

scientific article published on 01 October 1993

Regulation of immune responses by neutrophils.

scientific article published on 21 May 2014

Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: A New Hypothesis for Autoimmune Diseases.

scientific article

Sequential analysis of the thymocyte differentiation in fully allogeneic bone marrow chimera in mice. II. Further characterization of the CD4+ or CD8+ single positive thymocytes

scientific article published on 01 February 1990

Sialic Acids on Varicella-Zoster Virus Glycoprotein B Are Required for Cell-Cell Fusion

scientific article

Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA.

scientific article

Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor

scientific article

Structural basis for RIFIN-mediated activation of LILRB1 in malaria

scientific article published on 10 July 2020

Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILR

scientific article

Th1 and Th2 subsets equally undergo Fas‐dependent and ‐independent activation‐induced cell death ⬇️

scientific article published on August 1, 1997

The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells

scientific article

The β2-glycoprotein I/HLA-DR complex is the major autoantibody target in obstetric antiphospholipid syndrome

scientific article published on 24 June 2020

Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules

scientific article published on 18 January 2013

Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells

scientific article

Virus-driven evolution of natural killer cell receptors.

scientific article

β2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome.

scientific article published on 2 March 2015

List of works by Hisashi Arase

A Di-leucine Signal in the Ubiquitin Moiety

A motif in LILRB2 critical for Angptl2 binding and activation.

A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor alpha (PILRalpha) abrogates PILRalpha-dependent viral entry and reduces pathogenesis

Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor

Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility

Bimodal regulation of T cell-mediated immune responses by TIM-4

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.

Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors.

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

Cell components required for deletion of an autoreactive T cell repertoire

Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function

Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5

Crucial role of Jak3 in negative selection of self-reactive T cells.

Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.

Differential contribution of the FcR gamma chain to the surface expression of the T cell receptor among T cells localized in epithelia: analysis of FcR gamma-deficient mice

Differential effects on cell fusion activity of mutations in herpes simplex virus 1 glycoprotein B (gB) dependent on whether a gD receptor or a gB receptor is overexpressed

Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.

Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration

Engineering large viral DNA genomes using the CRISPR-Cas9 system

Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.

Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations

Functional studies on MEL-14+ and MEL-14− T cells in peripheral lymphoid tissues ⬇️

Genotype and phenotype analysis of patients with pediatric cutaneous mastocytosis, especially wild-type KIT patients

HSV-1 infection through inhibitory receptor, PILRalpha.

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages

Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis.

Invariant chain p41 mediates production of soluble MHC class II molecules

Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration

Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection

Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation.

Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2

Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors

Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway

Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα.

NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules

Negative regulation of DSS-induced experimental colitis by PILRα.

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation

Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1 ⬇️

Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.

PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues.

Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system

Preferential requirement of CD3 zeta-mediated signals for development of immature rather than mature thymocytes.

Reconstitution of lymphoid tissues under the influence of a subclinical level of graft versus host reaction induced by bone marrow T cells or splenic T cell subsets

Regulation of immune responses by neutrophils.

Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: A New Hypothesis for Autoimmune Diseases.

Sequential analysis of the thymocyte differentiation in fully allogeneic bone marrow chimera in mice. II. Further characterization of the CD4+ or CD8+ single positive thymocytes

Sialic Acids on Varicella-Zoster Virus Glycoprotein B Are Required for Cell-Cell Fusion

Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA.

Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor

Structural basis for RIFIN-mediated activation of LILRB1 in malaria

Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILR

Th1 and Th2 subsets equally undergo Fas‐dependent and ‐independent activation‐induced cell death ⬇️

The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells

The β2-glycoprotein I/HLA-DR complex is the major autoantibody target in obstetric antiphospholipid syndrome

Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules

Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells

Virus-driven evolution of natural killer cell receptors.

β2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome.