List of works - David J Wyllie

2B or 2B and 2D? - that is the question

scientific article

3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) Stereoisomers as Conformational Probes for Exploring Agonist Binding at NMDA Receptors

scientific article published on 12 June 2012

A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum.

scientific article

A rise in postsynaptic Ca2+ potentiates miniature excitatory postsynaptic currents and AMPA responses in hippocampal neurons.

scientific article

Activation of glutamate receptors and glutamate uptake in identified macroglial cells in rat cerebellar cultures.

scientific article published in January 1991

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity

scientific article

Altered dendritic spine function and integration in a mouse model of fragile X syndrome

scientific article published on 23 October 2019

Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

scientific article published on 6 February 2018

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

scientific article

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

scientific article published on August 2017

Cellular and Synaptic Phenotype Compensations Limit Circuit Disruption in Fmr1-KO Mouse Layer 4 Barrel Cortex but Fail to Prevent Deficits in Information Processing

Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex

scientific article published on 23 October 2019

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

scientific article published on June 2013

Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS.

scientific article

Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice

scientific article

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

scientific article published on 19 June 2020

Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors

scientific article published on 01 November 1995

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

scientific article

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

scientific article

Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons

scientific article

Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies

scientific article

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

scientific article published on October 2016

Fragile X syndrome: from targets to treatments

scientific article published on 17 December 2012

Functional assessment of the NMDA receptor variant GluN2A R586K.

scientific article

Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy

scientific article published on 30 January 2019

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

scientific article

GRIN2A-related disorders: genotype and functional consequence predict phenotype

scientific article published on 01 January 2019

Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells.

scientific article

Glutamate receptor gating.

scientific article

Glutamate-receptor channels in mammalian glial cells.

scientific article published on January 1991

Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization

scientific article published on 16 November 2009

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration

scientific article

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

scientific article published on 12 December 2015

Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors

scientific journal article

Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones

scientific article published on 18 August 2005

Influence of GluN2 subunit identity on NMDA receptor function.

scientific article published on 31 January 2013

Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors

scientific journal article

Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression.

scientific article published on 16 January 2009

Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit.

scientific article published on 24 April 2009

Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies

scientific article published in December 2009

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

scientific article published on 10 July 2012

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones

scientific article

Late-phase, protein synthesis-dependent long-term potentiation in hippocampal CA1 pyramidal neurones with destabilized microtubule networks.

scientific article published on 4 June 2007

Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans.

scientific article

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells

scientific article published on 01 August 2018

Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses

scientific article published on 12 January 2017

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes

scientific article published on 13 January 2016

Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons

scientific article published on March 2014

Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog.

scientific article published on August 2005

Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

scientific article published on 25 October 2007

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

scientific article published on January 2013

Modelling the details: integrating structure with function

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

scientific article published on 25 October 2007

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

scientific article published on 26 March 2012

NMDA receptor permeation: a light in the tunnel

scientific article published on 24 February 2012

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ⬇️

scientific article

Neuronal homeostasis: time for a change?

scientific article published on 08 August 2011

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

scientific article

PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity

scientific journal article

Parvalbumin interneurons in the dorsal horn: it's not all about GABA.

scientific article published on 25 October 2017

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

scientific journal article

Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors

scientific article

Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels.

scientific article published in May 2006

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells

scientific article published on 17 January 2014

Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.

scientific article

Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons

scientific article published in January 2018

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

scientific article

Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs ⬇️

scientific article published on October 16, 2010

Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure

scientific article published on 10 February 2013

Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA γ2 R43Q mouse model of absence epilepsy

scientific article

Single cell RT-PCR reaches out to the NMDA receptor

scientific article published on 01 February 1997

Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit

scientific article published on 18 May 2006

Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits

scientific article published in December 2009

Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells

scientific article published on 01 June 2000

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand

scientific article published in October 2008

Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

scientific article

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors.

scientific article published on 10 July 2007

Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles.

scientific article

Suppression of the intrinsic apoptosis pathway by synaptic activity.

scientific article

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome

scientific article published on 01 May 2019

SynGAP isoforms exert opposing effects on synaptic strength

scientific article

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

scientific article published on 23 March 2008

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

scientific article published on 17 February 2017

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences

article

The human NMDA receptor GluN2AN615K variant influences channel blocker potency.

scientific article published on 20 June 2019

The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells

scientific article published on 10 January 2006

The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults

scientific article

The ups and downs of synaptic plasticity: influences on this particular 'market'.

scientific article

VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S).

scientific article published on 25 March 2008

List of works by David J Wyllie

2B or 2B and 2D? - that is the question

3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) Stereoisomers as Conformational Probes for Exploring Agonist Binding at NMDA Receptors

A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum.

A rise in postsynaptic Ca2+ potentiates miniature excitatory postsynaptic currents and AMPA responses in hippocampal neurons.

Activation of glutamate receptors and glutamate uptake in identified macroglial cells in rat cerebellar cultures.

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity

Altered dendritic spine function and integration in a mouse model of fragile X syndrome

Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

Cellular and Synaptic Phenotype Compensations Limit Circuit Disruption in Fmr1-KO Mouse Layer 4 Barrel Cortex but Fail to Prevent Deficits in Information Processing

Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS.

Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons

Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

Fragile X syndrome: from targets to treatments

Functional assessment of the NMDA receptor variant GluN2A R586K.

Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

GRIN2A-related disorders: genotype and functional consequence predict phenotype

Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells.

Glutamate receptor gating.

Glutamate-receptor channels in mammalian glial cells.

Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors

Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones

Influence of GluN2 subunit identity on NMDA receptor function.

Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors

Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression.

Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit.

Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones

Late-phase, protein synthesis-dependent long-term potentiation in hippocampal CA1 pyramidal neurones with destabilized microtubule networks.

Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans.

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells

Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes

Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons

Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog.

Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

Modelling the details: integrating structure with function

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

NMDA receptor permeation: a light in the tunnel

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ⬇️

Neuronal homeostasis: time for a change?

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity

Parvalbumin interneurons in the dorsal horn: it's not all about GABA.

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors

Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels.

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells

Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.

Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs ⬇️

Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure

Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA γ2 R43Q mouse model of absence epilepsy

Single cell RT-PCR reaches out to the NMDA receptor

Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit

Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits

Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand

Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors.

Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles.

Suppression of the intrinsic apoptosis pathway by synaptic activity.