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List of works by Emmanuel Lemichez

ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments

scientific article published on 14 November 2017

ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion

scientific article published on 25 September 2005

Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process

scientific article published on 17 December 2007

Activation and proteasomal degradation of rho GTPases by cytotoxic necrotizing factor-1 elicit a controlled inflammatory response

scientific article published on 19 May 2004

Assessing ubiquitylation of Rho GTPases in mammalian cells

scientific article published in January 2012

Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions.

scientific article

Bacillus sphaericus binary toxin elicits host cell autophagy as a response to intoxication

scientific article (publication date: 2011)

Bacteria and the ubiquitin pathway

scientific article published on 6 December 2006

Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?

scientific article

Breaking the wall: targeting of the endothelium by pathogenic bacteria

scientific article published on 30 December 2009

CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion

scientific article published in November 2002

CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells

scientific article

CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.

scientific article

Cellular Dewetting: Opening of Macroapertures in Endothelial Cells

scientific article published in Physical Review Letters

Cellular microbiology: Bacterial toxin interference drives understanding of eukaryotic cell function

scientific article published on 01 April 2020

Characterization of a cluster of oncogenic mutations in E6 of a human papillomavirus 83 variant isolated from a high-grade squamous intraepithelial lesion

scientific article published on 13 July 2011

Cholera toxin notches epithelial junctions

scientific article published in September 2013

Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery

scientific article published on 25 September 2015

Coxiella burnetii, the agent of Q fever, replicates within trophoblasts and induces a unique transcriptional response

scientific article

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells

scientific article

Cross-talk between RhoGTPases and stress activated kinases for matrix metalloproteinase-9 induction in response to keratinocytes injury

scientific article published in December 2003

Decoding glycan recognition by bacterial toxins

scientific article published in February 2018

Direct modifications of Rho proteins: deconstructing GTPase regulation

scientific article published on 06 April 2010

E. coli CNF1 toxin: a two-in-one system for host-cell invasion.

scientific article published on April 2004

EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia

scientific article

Escherichia coli producing CNF1 toxin hijacks Tollip to trigger Rac1-dependent cell invasion

scientific article published on 25 February 2011

Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia

scientific article

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

scientific article published on 20 September 2018

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

Force-induced transcellular tunnel formation in endothelial cells

scientific article

General aspects and recent advances on bacterial protein toxins

scientific article published on February 2013

Genetic Diversity and Population Structure of Leishmania infantum from Southeastern France: Evaluation Using Multi-Locus Microsatellite Typing

scientific article published on 25 January 2016

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

scientific article published on 23 January 2018

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

scientific article published on January 2013

Hijacking of Rho GTPases during bacterial infection ⬇️

scientific article published on 03 May 2013

IRSp53 senses negative membrane curvature and phase separates along membrane tubules

scientific article

Immunoadjuvant Properties of the Rho Activating Factor CNF1 in Prophylactic and Curative Vaccination against Leishmania infantum

scientific article

Impaired Stimulation of p38α-MAPK/Vps41-HOPS by LPS from Pathogenic Coxiella burnetii Prevents Trafficking to Microbicidal Phagolysosomes

scholarly article published by Philippe Soubeyran in 2012

In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification

scientific article published in 2022

In vitro selective elimination of HIV-infected cells from peripheral blood in AIDS patients by the immunotoxin DAB389CD4 ⬇️

scientific article published on May 28, 1998

Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors

scientific article

Inhibition of p21 Rho in intact cells by C3 diphtheria toxin chimera proteins.

scientific article published on January 1995

Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.

scientific article published on 19 December 2014

Injection of Staphylococcus aureus EDIN by the Bacillus anthracis protective antigen machinery induces vascular permeability

scientific article

Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

scientific article published on 01 July 2001

Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection

scientific article

Intranasal immunization with tetanus toxoid and CNF1 as a new mucosal adjuvant protects BALB/c mice against lethal challenge

scientific article published in November 2007

Isoform-specific interaction of C-RAF with mitochondria

scientific article

Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells

scientific article published on 8 July 2011

Luciferase-expressing Leishmania infantum allows the monitoring of amastigote population size, in vivo, ex vivo and in vitro

scientific article

Microbial pathogenesis meets biomechanics

scientific article published on 2 February 2016

Modification of Salmonella Typhimurium motility by the probiotic yeast strain Saccharomyces boulardii

scientific article (publication date: 2012)

New Aspects on Bacterial Effectors Targeting Rho GTPases

scientific article

Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis

scientific article published on 26 June 2008

Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells

scientific article published on 12 May 2005

Rac GTPase instructs nuclear factor-kappaB activation by conveying the SCF complex and IkBalpha to the ruffling membranes

scientific article published on 10 December 2003

Rac homologues and compartmentalized phosphatidylinositol 4, 5-bisphosphate act in a common pathway to regulate polar pollen tube growth.

scientific article

Rac1 est la cible de l’activité E3 ubiquitine-ligase du suppresseur de tumeur HACE1

scientific article published on 27 January 2012

Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.

scientific article published on April 1996

Response from Emmanuel Lemichez: A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors

scientific article published in April 2003

Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology

scientific article published on 3 August 2007

Role of N-terminal His6-Tags in binding and efficient translocation of polypeptides into cells using anthrax protective antigen (PA)

scientific article

Saccharomyces boulardii modifies Salmonella typhimurium traffic and host immune responses along the intestinal tract

scientific article

Screening in planarians identifies MORN2 as a key component in LC3-associated phagocytosis and resistance to bacterial infection

scientific article published on September 2014

Screening of drug library identifies inhibitors of cell intoxication by CNF1.

scientific article published on 23 January 2018

Severity of Escherichia coli bacteraemia is independent of the intrinsic virulence of the strains assessed in a mouse model.

scientific article published on 23 January 2012

Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli

scientific article published on 01 January 2007

Switching Rho GTPase activation into effective antibacterial defenses requires the caspase-1/IL-1beta signaling axis

scientific article published on 22 October 2015

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

scientific article

Targeting of host-cell ubiquitin and ubiquitin-like pathways by bacterial factors

scientific article published in October 2004

The <i>cnf1</i> gene is associated with an expanding <i>Escherichia coli</i> ST131 <i>H</i>30Rx/C2 subclade and confers a competitive advantage for gut colonization

scientific article published in 2022

The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1

scientific article

The Rho GTPase activators CNF1 and DNT bacterial toxins have mucosal adjuvant properties

scientific article published on 01 April 2005

The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt

scientific article

The Saccharomyces boulardii CNCM I-745 strain shows protective effects against the B. anthracis LT toxin

scientific article published on 30 October 2015

The Staphylococcus aureus epidermal cell differentiation inhibitor toxin promotes formation of infection foci in a mouse model of bacteremia

scientific article

The evolution of contact-dependent inhibition in non-growing populations of Escherichia coli

scientific article published in January 2008

To be helped or not helped, that is the question

scientific article published on March 2003

Toxins activating Rho GTPases and exploiting the cellular ubiquitin/proteasome machineries

Transcellular tunnel dynamics: Control of cellular dewetting by actomyosin contractility and I-BAR proteins

scientific article published on 03 January 2013

Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity

scientific article

Ubiquitin-mediated proteasomal degradation of Rho proteins by the CNF1 toxin

scientific article published in January 2006

Urinary interleukin-8 is elevated in urinary tract infections independently of the causative germs

scientific article published on 01 September 2005

alpha2beta1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells

scientific article published in July 2010

cAMP Signaling by Anthrax Edema Toxin Induces Transendothelial Cell Tunnels, which Are Resealed by MIM via Arp2/3-Driven Actin Polymerization

scientific article published on 01 November 2011

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