List of works by Struan F.A. Grant

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry

article

3D promoter architecture re-organization during iPSC-derived neuronal cell differentiation implicates target genes for neurodevelopmental disorders

scientific article published on 02 February 2021

A ChIP-seq-defined genome-wide map of MEF2C binding reveals inflammatory pathways associated with its role in bone density determination.

scientific article published on 15 December 2013

A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.

scientific article

A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites.

scientific article published on 9 February 2017

A Global Perspective of Latent Autoimmune Diabetes in Adults

scientific article published on 23 July 2018

A Unified Pathophysiological Construct of Diabetes and its Complications

scientific article

A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.

scientific article published on 24 May 2013

A genome-wide association meta-analysis identifies new childhood obesity loci

scientific article

A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.

scientific article

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

scientific article

A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24.

scientific article

A genome-wide association study on obesity and obesity-related traits

scientific article published on 28 April 2011

A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci

scientific journal article

A genome-wide study reveals copy number variants exclusive to childhood obesity cases

scientific article

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

scientific article

A meta-analysis of the transferability of bone mineral density genetic loci associations from European to African ancestry populations

scientific article published on 29 November 2020

A novel common variant in DCST2 is associated with length in early life and height in adulthood

scientific article published on 3 October 2014

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study

scientific article

A trans-ethnic genome-wide association study identifies gender-specific loci influencing pediatric aBMD and BMC at the distal radius.

scientific article published on 3 June 2015

ATOM: a powerful gene-based association test by combining optimally weighted markers

scientific article published on 15 December 2008

Advances in Whole Genome Sequencing Technology ⬇️

scientific article published on February 1, 2011

Allelic expression imbalance: tipping the scales to elucidate the function of type 2 diabetes-associated loci.

scientific article published on April 2015

Association Between Linear Growth and Bone Accrual in a Diverse Cohort of Children and Adolescents

scientific article published on 3 July 2017

Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.

scientific article

Association analysis of type 2 diabetes Loci in type 1 diabetes.

scientific article published on 21 April 2008

Association between a high-risk autism locus on 5p14 and social communication spectrum phenotypes in the general population

scientific article

Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies.

scientific article published on 21 May 2009

Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes

scientific article published on 6 April 2014

Association of the BANK 1 R61H variant with systemic lupus erythematosus in Americans of European and African ancestry.

scientific article

Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease

scientific article

Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis

scientific article published on 01 July 2008

Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease

scientific article (publication date: August 2007)

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

scientific article

BMD-associated variation at the Osterix locus is correlated with childhood obesity in females

scientific article published on 06 January 2011

Body mass index (BMI) trajectories in infancy differ by population ancestry and may presage disparities in early childhood obesity

scientific article

CRISPR-Cas9-Mediated Genome Editing Confirms <i>EPDR1</i> as an Effector Gene at the BMD GWAS-Implicated '<i>STARD3NL</i>' Locus

scientific article published on 23 July 2021

Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?

scientific article

Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2.

scientific article

Chromosome 6p22 locus associated with clinically aggressive neuroblastoma

scientific article

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits

scientific article published on 19 November 2021

Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4-LEF1 Binding

scientific article published on 19 February 2021

Common genetic variants on 5p14.1 associate with autism spectrum disorders

scientific article

Common variants at 12q15 and 12q24 are associated with infant head circumference

scientific article published on 15 April 2012

Common variants at 5q22 associate with pediatric eosinophilic esophagitis

scientific journal article

Common variations in BARD1 influence susceptibility to high-risk neuroblastoma

scientific article

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

scientific article

Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

scientific article

Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women.

scientific article

Copy number variation at 1q21.1 associated with neuroblastoma

scientific article

Copy number variation on chromosome 10q26.3 for obesity identified by a genome-wide study

scientific article published on 21 November 2012

Copy number variations in alternative splicing gene networks impact lifespan

scientific article

Correction: A Genome-Wide Association Study on Obesity and Obesity-Related Traits.

scientific article

DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.

scientific article

Developmental origins of genotype-phenotype correlations in chronic diseases of old age.

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.

scientific article

Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes.

scientific article published on 30 March 2016

Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease

scientific article

Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder

scientific article

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

scholarly article published in Nature Genetics

Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume

article

Ethnic disparities in DNA methylation and risk of type 2 diabetes.

scientific article published on 18 June 2015

Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.

scientific article

Examination of genetic variants influencing lipid traits in pediatric populations.

scientific article

Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.

scientific article published on 10 July 2009

FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: The BCAMS Study

scientific article

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

scientific article published on 25 September 2018

Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes

scientific article

From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes.

scientific article

GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk.

scientific article published on January 2013

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

scientific article published on 04 September 2019

Genes and osteoporosis

scientific article published on 01 August 1997

Genetic Determinants of Childhood Obesity

scientific article published on 01 October 2020

Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

scientific article published on 16 December 2019

Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density.

scientific article published on 17 November 2015

Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans.

scientific article

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

scientific article

Genetic sharing and heritability of paediatric age of onset autoimmune diseases.

scientific article

Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.

scientific article published on 25 February 2014

Genetic variation in genes encoding airway epithelial potassium channels is associated with chronic rhinosinusitis in a pediatric population.

scientific article

Genetically Determined Birthweight Associates with Atrial Fibrillation: A Mendelian Randomization Study

scientific article published on 27 April 2020

Genetics of Bone Mass in Childhood and Adolescence: Effects of Sex and Maturation Interactions

scientific article published on 12 March 2015

Genetics of childhood obesity

scientific article

Genetics of obesity and type 2 diabetes in African Americans.

scientific article published on 19 March 2013

Genetics of pediatric bone strength

scientific article published on 20 July 2016

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density

article

Genome-wide analyses of ChIP-Seq derived FOXA2 DNA occupancy in liver points to genetic networks underpinning multiple complex traits.

scientific article

Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes

scientific article

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

scientific article published on 24 November 2015

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

scientific article

Genome-wide association of body fat distribution in African ancestry populations suggests new loci

scientific article

Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes.

scientific article published on October 2011

Genome-wide association studies in type 1 diabetes, inflammatory bowel disease and other immune-mediated disorders.

scientific article published on July 2009

Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.

scientific article

Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).

scientific article

Genome-wide associations for birth weight and correlations with adult disease

scientific article

Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder

scientific article

Genotype and Tissue-Specific Effects on Alternative Splicing of the Transcription Factor 7-Like 2 Gene in Humans.

scientific article published in February 2010

Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans

scientific article

High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications.

scientific article published on 10 July 2009

IL-1 Transcriptional Responses to Lipopolysaccharides Are Regulated by a Complex of RNA Binding Proteins

scientific article published on 17 January 2020

Identical osteochondritis dissecans lesions of the knee in sets of monozygotic twins.

scientific article

Identification of Genetic and Environmental Factors Predicting Metabolically Healthy Obesity in Children: Data From the BCAMS Study

scientific article

Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.

scientific article published on 11 February 2016

Implicating candidate genes at GWAS signals by leveraging topologically associating domains.

scientific article published on 09 August 2017

In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium.

scientific article published on 8 April 2010

Infant BMI or Weight-for-Length and Obesity Risk in Early Childhood.

scientific article published on May 2016

Influence of SNP*SNP interaction on BMI in European American adolescents: findings from the National Longitudinal Study of Adolescent Health

scientific article

Integrative genomics identifies LMO1 as a neuroblastoma oncogene

scientific article

Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry

scientific article published on 5 March 2009

Lack of relationship between mitochondrial heteroplasmy or variation and childhood obesity.

scientific article published on 18 October 2011

Large copy-number variations are enriched in cases with moderate to extreme obesity.

scientific article published on 9 July 2010

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

scientific article

Leveraging epigenomics and contactomics data to investigate SNP pairs in GWAS

scientific article published on 24 May 2018

Leveraging genetic discoveries for sleep to determine causal relationships with common complex traits

scientific article published in 2022

Leveraging putative enhancer-promoter interactions to investigate two-way epistasis in Type 2 Diabetes GWAS.

scientific article published in January 2018

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

scientific article published in January 2018

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

scientific article

Long PCR detection of the C4A null allele in B8-C4AQ0-C4B1-DR3

scientific article published on 01 October 2000

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

scientific article

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

scientific article published on 01 December 2018

Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells

scientific article published on 03 July 2020

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

scientific article published on 01 May 2019

Mendelian randomization in the era of genomewide association studies.

scientific article published on 11 March 2010

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

scientific article

Microarray technology and applications in the arena of genome-wide association.

scientific article published on 22 May 2008

Modeling genetic inheritance of copy number variations.

scientific article published on 02 October 2008

Multi-dimensional bone density phenotyping reveals new insights in to genetic regulation of the pediatric skeleton

scientific article

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

scientific article published on 2 December 2012

Next steps in the identification of gene targets for type 1 diabetes

scientific article published on 14 August 2020

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

scientific article published on 12 October 2020

ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry.

scientific article

Obesity-susceptibility loci and the tails of the pediatric BMI distribution.

scientific article published on June 2013

Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults.

scientific article published on January 2014

PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells.

scientific article published in February 2018

Pathway-Based Genome-Wide Association Studies for Plasma Triglycerides in Obese Females and Normal-Weight Controls

scientific article published on 26 August 2015

Pathway-Based Genome-wide Association Studies Reveal That the Rac1 Pathway Is Associated with Plasma Adiponectin Levels.

scientific article

Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation.

scientific article published on 5 July 2011

Pharmacogenetics and pharmacogenomics: tailored drug therapy for the 21st century

scientific article published on 01 January 2001

Physical Activity Benefits the Skeleton of Children Genetically Predisposed to Lower Bone Density in Adulthood

scientific article

Physical activity and physical fitness: standardizing assessment with the PhenX Toolkit

scientific article

Polymorphisms of the interleukin-6 gene are associated with bone mineral density

scientific article published on 01 July 1997

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Public resources aid diabetes gene discovery

article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article

Rare EN1 Variants and Pediatric Bone Mass

scientific article

Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations

scientific article published on 14 January 2020

Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes

scientific article

Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes.

scientific article

Re: Ward K, Ogilvie JW, Singleton, et al. Validation of DNA-based prognostic testing to predict spinal curve progression in adolescent idiopathic scoliosis. Spine 2010;35:E1455-64

scientific article published on 01 July 2011

Recent development in pharmacogenomics: from candidate genes to genome-wide association studies.

scientific article published on July 2007

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

article

Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women

scientific article published on 01 April 1998

Relative Skeletal Maturation and Population Ancestry in Nonobese Children and Adolescents.

scientific article published on 15 July 2016

Relevance of polymorphisms in MC4R and BDNF in short normal stature

scientific article published on 22 August 2018

Remapping the type I diabetes association of the CTLA4 locus

scientific article

Response to Comment on Schwartz et al. The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell-Centric Classification Schema. Diabetes Care 2016;39:179-186.

scientific article published in August 2016

Restriction enzyme selection dictates detection range sensitivity in chromatin conformation capture-based variant-to-gene mapping approaches

scientific article published on 18 August 2021

SNP array mapping of chromosome 20p deletions: genotypes, phenotypes, and copy number variation

scientific article published on March 2009

Sleep Duration and Cardiometabolic Risk Among Chinese School-aged Children: Do Adipokines Play a Mediating Role?

scientific article published on 9 March 2017

Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes

scientific article

Strategies for Genetic Studies of Complex Diseases ⬇️

scientific article published on 01 August 2010

Strong synaptic transmission impact by copy number variations in schizophrenia

scientific article

Teasing Diabetes Apart, One Locus at a Time

scientific article

The Dynamic Origins of Type 1 Diabetes

scientific article published on 01 December 2018

The Genetics of Pediatric Obesity.

scientific article

The TCF7L2 Locus: A Genetic Window Into the Pathogenesis of Type 1 and Type 2 Diabetes

scientific article published on 13 August 2019

The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell-Centric Classification Schema.

scientific article published on February 2016

The genetics of human obesity

article

The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry.

scientific article published on January 2013

The relationship between selected physiological variables of rowers and rowing performance as determined by a 2000 m ergometer test.

scientific article published in November 1999

The role of established East Asian obesity-related loci on pediatric leptin levels highlights a neuronal influence on body weight regulation in Chinese children and adolescents: the BCAMS study

scientific article published on 24 August 2017

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature

scientific article

The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI

scientific article

The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented in Hereditary Multiple Exostoses: insights into pathogenesis

scientific article

The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.

scientific article published on 18 August 2016

The type I diabetes association of the IL2RA locus.

scientific article

Trans-ethnic Evaluation Identifies Novel Low Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations.

scientific article published on 9 January 2018

Transcriptome profiling of human ulcerative colitis mucosa reveals altered expression of pathways enriched in genetic susceptibility loci

scientific article

Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study

scientific article published on 27 November 2012

Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data

scientific article

Understanding the elusive mechanism of action of TCF7L2 in metabolism.

scientific article

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

scientific article (publication date: March 2006)

Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits

scientific article published in 2022

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

scientific article

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

article

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

scientific article published on 02 September 2019

Variants of DENND1B associated with asthma in children

scientific article

Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population.

scientific article published in March 1996

What's New in Osteoporosis? ⬇️

scientific article published on February 1, 1995

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