List of works - Mihály Józsi

Analysis of Linear Antibody Epitopes on Factor H and CFHR1 Using Sera of Patients with Autoimmune Atypical Hemolytic Uremic Syndrome.

scientific article published on 30 March 2017

Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome

scientific article

Anti-factor B autoantibody in dense deposit disease

scientific article published on 01 March 2010

Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.

scientific article

Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome.

scientific article

Autoimmune forms of thrombotic microangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles

scientific article

C3 glomerulopathy - understanding a rare complement-driven renal disease

scientific article published on 01 March 2019

Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4.

scientific article published on 17 April 2018

Complement and diseases: defective alternative pathway control results in kidney and eye diseases

scientific article

Complement factor H modulates the activation of human neutrophil granulocytes and the generation of neutrophil extracellular traps.

scientific article

Complement factor H-antibody-associated hemolytic uremic syndrome: pathogenesis, clinical presentation, and treatment

scientific article

Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)

scientific article

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome

scientific article

Differential Interaction of the Two Related Fungal SpeciesCandida albicansandCandida dubliniensiswith Human Neutrophils ⬇️

scientific article published on July 30, 2012

Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum

scientific article published on 20 December 2019

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

scientific article

FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene.

scientific article

Factor H Family Proteins in Complement Evasion of Microorganisms

scientific article

Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions

scientific article

Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity.

scientific article published on 11 December 2009

Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency

scientific article

Factor H family proteins and human diseases

scientific article

Factor H inhibits complement activation induced by liposomal and micellar drugs and the therapeutic antibody rituximab in vitro.

scientific article

Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein ⬇️

scientific article published on April 19, 2012

Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome

scientific article

Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation

scientific article

Factor H-related proteins determine complement-activating surfaces

scientific article published on 13 May 2015

Factor H-related proteins.

scientific article published on January 2014

Factor h: a complement regulator in health and disease, and a mediator of cellular interactions.

scientific article published on 07 February 2012

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

scientific article published on 23 July 2018

Functional Characterization of the Disease-Associated N-Terminal Complement Factor H Mutation W198R.

scientific article published on 13 December 2017

Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome

scientific article

Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells

scientific article

Heterogeneity but individual constancy of epitopes, isotypes and avidity of factor H autoantibodies in atypical hemolytic uremic syndrome

scientific article

Human pentraxin 3 binds to the complement regulator c4b-binding protein.

scientific article

Infusion Reactions Associated with the Medical Application of Monoclonal Antibodies: The Role of Complement Activation and Possibility of Inhibition by Factor H

scientific article published on 14 March 2018

Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BP

scientific article published on 30 January 2012

Mannan-binding lectin and C1q bind to distinct structures and exert differential effects on macrophages

scientific article published on 01 June 2000

Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4

scientific article published on 29 December 2009

Neutrophil activation during attacks in patients with hereditary angioedema due to C1-inhibitor deficiency

scientific article

Pathogenic Leptospira species acquire factor H and vitronectin via the surface protein LcpA.

scientific article published on 22 December 2014

Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils

scientific article published on 4 August 2011

Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18).

scientific article published on 22 August 2015

Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients.

scientific article published on 6 January 2016

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

scientific article published on 12 July 2018

The C-terminus of complement factor H is essential for host cell protection

scientific article published on 17 January 2007

The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein

scientific article published on 01 May 2006

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

scientific article published on 19 September 2017

The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease. ⬇️

scientific article

Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)

scientific article

List of works by Mihály Józsi

Analysis of Linear Antibody Epitopes on Factor H and CFHR1 Using Sera of Patients with Autoimmune Atypical Hemolytic Uremic Syndrome.

Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome

Anti-factor B autoantibody in dense deposit disease

Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.

Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome.

Autoimmune forms of thrombotic microangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles

C3 glomerulopathy - understanding a rare complement-driven renal disease

Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4.

Complement and diseases: defective alternative pathway control results in kidney and eye diseases

Complement factor H modulates the activation of human neutrophil granulocytes and the generation of neutrophil extracellular traps.

Complement factor H-antibody-associated hemolytic uremic syndrome: pathogenesis, clinical presentation, and treatment

Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome

Differential Interaction of the Two Related Fungal SpeciesCandida albicansandCandida dubliniensiswith Human Neutrophils ⬇️

Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene.

Factor H Family Proteins in Complement Evasion of Microorganisms

Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions

Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity.

Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency

Factor H family proteins and human diseases

Factor H inhibits complement activation induced by liposomal and micellar drugs and the therapeutic antibody rituximab in vitro.

Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein ⬇️

Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome

Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation

Factor H-related proteins determine complement-activating surfaces

Factor H-related proteins.

Factor h: a complement regulator in health and disease, and a mediator of cellular interactions.

Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

Functional Characterization of the Disease-Associated N-Terminal Complement Factor H Mutation W198R.

Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome

Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells

Heterogeneity but individual constancy of epitopes, isotypes and avidity of factor H autoantibodies in atypical hemolytic uremic syndrome

Human pentraxin 3 binds to the complement regulator c4b-binding protein.

Infusion Reactions Associated with the Medical Application of Monoclonal Antibodies: The Role of Complement Activation and Possibility of Inhibition by Factor H

Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BP

Mannan-binding lectin and C1q bind to distinct structures and exert differential effects on macrophages

Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4

Neutrophil activation during attacks in patients with hereditary angioedema due to C1-inhibitor deficiency

Pathogenic Leptospira species acquire factor H and vitronectin via the surface protein LcpA.

Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils

Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18).

Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients.

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

The C-terminus of complement factor H is essential for host cell protection

The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease. ⬇️

Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)