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List of works by Didier Le Roy

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

scientific article published in October 2009

Activity and specificity of a mouse monoclonal antibody to ferric aerobactin ⬇️

scientific article published on March 1, 1992

Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

scientific article published on 18 November 2020

Critical Role of Lipopolysaccharide-Binding Protein and CD14 in Immune Responses against Gram-Negative Bacteria

article

Expression and function of macrophage migration inhibitory factor (MIF) in melioidosis

scientific article

Fully human anti-macrophage migration inhibitory factor antibodies as potential therapeutics for sepsis and septic shock.

scientific article

Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis

scientific article published on 14 March 2016

High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates

scientific article published on 8 February 2016

Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

scientific article published on 18 October 2010

Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation.

scientific article published on 10 September 2009

IFN-gamma involvement in the severity of gram-negative infections in mice.

scientific article

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action

scientific article

Immunological variants of the aerobactin-cloacin DF13 outer membrane protein receptor IutA among enteric bacteria.

scientific article

Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo

scientific article

Innate Immune Sensing of Fusarium culmorum by Mouse Dendritic Cells.

scientific article published on January 2015

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

scientific article

Lipopolysaccharide binding protein as a marker of inflammation in synovial fluid of patients with arthritis: correlation with interleukin 6 and C-reactive protein

scientific article published on 01 July 1995

Lipopolysaccharide-binding protein as a major plasma protein responsible for endotoxemic shock ⬇️

scientific article published on November 1, 1993

MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) IN MENINGOCOCCAL SEPTIC SHOCK AND EXPERIMENTAL HUMAN ENDOTOXEMIA

scientific article published on 01 May 2007

Macrophage migration inhibitory factor deficiency is associated with impaired killing of gram-negative bacteria by macrophages and increased susceptibility to Klebsiella pneumoniae sepsis

scientific article

Mode of action of anti-lipopolysaccharide-binding protein antibodies for prevention of endotoxemic shock in mice.

scientific article published on August 1994

Monoclonal antibodies to murine lipopolysaccharide (LPS)-binding protein (LBP) protect mice from lethal endotoxemia by blocking either the binding of LPS to LBP or the presentation of LPS/LBP complexes to CD14.

scientific article published on June 1999

Mouse Model of Respiratory Tract Infection Induced by Waddlia chondrophila.

scientific article

Neutralization of macrophage migration inhibitory factor (MIF) by fully human antibodies correlates with their specificity for the β-sheet structure of MIF.

scientific article

Nitric oxide production in experimental gram-negative infection: studies with cytokine receptor-deficient mice ⬇️

scientific article published on July 1, 1998

Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.

scholarly article

Radioimmunoassay versus flow cytometric assay to quantify LPS-binding protein (LBP) concentrations in human plasma

scientific article published on 01 May 1994

Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and gram negative bacteria.

scientific article published on January 1995

Reply to: ‘Lack of evidence for intergenerational inheritance of immune resistance to infections’

scientific article published in 2022

Results of passive and active immunization directed against ferric aerobactin in experimental enterobacterial infections in mice and chickens

scientific article published on 01 February 1995

Role of MyD88 and Toll-like receptors 2 and 4 in the sensing of Parachlamydia acanthamoebae

scientific article

Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination

scientific article published on 15 February 2017

Similarities and disparities between core-specific and O-side-chain-specific antilipopolysaccharide monoclonal antibodies in models of endotoxemia and bacteremia in mice

scientific article

Streptococcus mitis cell walls and lipopolysaccharide induce lethality in D-galactosamine-sensitized mice by a tumor necrosis factor-dependent pathway.

scientific article

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

scientific article

The pathogenic role of LBP in gram-negative sepsis and septic shock.

scientific article published on January 1998

The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock.

scientific article

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.

scientific article

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