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List of works by Patricia L Opresko

Association of TERT promoter mutations with telomerase expression in melanoma

scientific article published on March 2016

Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage ⬇️

scientific article published on December 1, 2003

Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links

scientific article

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

scientific article

Convergence of The Nobel Fields of Telomere Biology and DNA Repair.

scientific article published on 18 November 2016

Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis

scientific article

Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study

scientific article (publication date: 2011)

DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions.

scientific article

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.

scientific article published on 13 September 2013

Educational attainment and late life telomere length in the Health, Aging and Body Composition Study

scientific article published on 5 September 2012

Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2.

scientific article published on 9 February 2016

Enzymatic mechanism of the WRN helicase/nuclease.

scientific article published on January 2006

Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins

scientific article published on 21 February 2022

Human RecQ helicases in DNA repair, recombination, and replication.

scientific article

Hybridization of G-quadruplex-forming peptide nucleic acids to guanine-rich DNA templates inhibits DNA polymerase η extension.

scientific article published on 05 August 2014

Hydrophobic interactions in the hinge domain of DNA polymerase beta are important but not sufficient for maintaining fidelity of DNA synthesis

scientific article published on 01 September 2000

Junction of RecQ helicase biochemistry and human disease.

scientific article

Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study

scientific article published on September 2009

Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase

scientific article

Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs

scientific article published on 20 October 2020

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

scientific article

POT1-TPP1 regulates telomeric overhang structural dynamics.

scientific article

Pathways defective in the human premature aging disease Werner syndrome

scientific article published on 01 January 2002

Polymerase η suppresses telomere defects induced by DNA damaging agents

scientific article

Replication protein A stimulates the Werner syndrome protein branch migration activity

scientific article published on 7 October 2009

Single Molecule Studies of Physiologically Relevant Telomeric Tails Reveal POT1 Mechanism for Promoting G-quadruplex Unfolding ⬇️

scientific article published on December 23, 2010

Single-molecule real-time detection of telomerase extension activity

scientific article

TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

scientific article published on 01 December 2021

TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres

scientific article

TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons.

scientific article published on 15 March 2006

Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.

scientific article published on 30 October 2007

Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro.

scientific article

Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta

scientific article published on 01 January 2006

Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts

scientific article published on 9 September 2015

Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins

scientific article

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.

scientific article

Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability

scientific article

The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation

scientific article

The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress

scientific article

The association of cataract with leukocyte telomere length in older adults: defining a new marker of aging

scientific article

The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

scientific article published on 01 February 1998

Unraveling secrets of telomeres: one molecule at a time.

scientific article

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

scientific article

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

scientific article

Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences

scientific article

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