List of works - Mutsuko Kukimoto-Niino

A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors

scientific article published on 21 January 2009

A redox switch shapes the Lon protease exit pore to facultatively regulate proteolysis

article published in 2014

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen

scientific article published on 16 June 2017

Application of nitrite reductase from Alcaligenes faecalis S-6 for nitrite measurement

scientific article published on 01 January 1998

Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.

scientific article

Catalytic roles for two water bridged residues (Asp-98 and His-255) in the active site of copper-containing nitrite reductase

scientific article

Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody-antigen interaction

scientific article published on 20 February 2018

Cell-permeable Carboxyl-terminal p27Kip1 Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase

scientific article

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

scientific article published on 31 July 2018

Crystal Structure of the Ca2+/Calmodulin-dependent Protein Kinase Kinase in Complex with the Inhibitor STO-609

scientific article

Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation

scientific article

Crystal structure of a predicted phosphoribosyltransferase (TT1426) from Thermus thermophilus HB8 at 2.01 A resolution

scientific article published on 2 February 2005

Crystal structure of an enhancer of rudimentary homolog (ERH) at 2.1 Angstroms resolution

scientific article

Crystal structure of the GTP-binding protein Obg from Thermus thermophilus HB8.

scientific article published in March 2004

Crystal structure of the RUN domain of the RAP2-interacting protein x

scientific journal article

Crystal structure of the human receptor activity-modifying protein 1 extracellular domain

scientific article

Crystal structure of the probable haloacid dehalogenase PH0459 from Pyrococcus horikoshii OT3.

scientific article

Crystal structures of possible lysine decarboxylases from Thermus thermophilus HB8

scientific article published on 30 September 2004

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

scientific article

Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.

scientific article

Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state

scientific article

Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex

scientific article

Identification of interaction site of pseudoazurin with its redox partner, copper-containing nitrite reductase from Alcaligenes faecalis S-6

scientific article published on 01 February 1995

Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures.

scientific article

Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors

scientific article published on 7 October 2017

Immune regulatory functions of DOCK family proteins in health and disease

scientific article published on 02 August 2013

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

scientific article

Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes

scientific article

Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression.

scientific article

Site-directed mutagenesis of azurin from Pseudomonas aeruginosa enhances the formation of an electron-transfer complex with a copper-containing nitrite reductase from Alcaligenes faecalis S-6

scientific article published on 01 September 1996

Site-directed mutants of pseudoazurin: explanation of increased redox potentials from X-ray structures and from calculation of redox potential differences

scientific article

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding

scientific article

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

scientific article

Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor

scientific article

Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases

scientific article

Structural basis for the specific recognition of the major antigenic peptide from the Japanese cedar pollen allergen Cry j 1 by HLA-DP5.

scientific article published on 11 July 2014

Structural basis of interleukin-5 dimer recognition by its α receptor

scientific article

Structure of the UNC5H2 death domain.

scientific article published on 23 November 2006

TNIK inhibition abrogates colorectal cancer stemness

scientific article published on 26 August 2016

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.

scientific article

Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities

scientific article

The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain

scientific journal article

X-ray structure and site-directed mutagenesis of a nitrite reductase from Alcaligenes faecalis S-6: roles of two copper atoms in nitrite reduction.

scientific article published on May 1994

List of works by Mutsuko Kukimoto-Niino

A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors

A redox switch shapes the Lon protease exit pore to facultatively regulate proteolysis

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen

Application of nitrite reductase from Alcaligenes faecalis S-6 for nitrite measurement

Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.

Catalytic roles for two water bridged residues (Asp-98 and His-255) in the active site of copper-containing nitrite reductase

Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody-antigen interaction

Cell-permeable Carboxyl-terminal p27Kip1 Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Crystal Structure of the Ca2+/Calmodulin-dependent Protein Kinase Kinase in Complex with the Inhibitor STO-609

Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation

Crystal structure of a predicted phosphoribosyltransferase (TT1426) from Thermus thermophilus HB8 at 2.01 A resolution

Crystal structure of an enhancer of rudimentary homolog (ERH) at 2.1 Angstroms resolution

Crystal structure of the GTP-binding protein Obg from Thermus thermophilus HB8.

Crystal structure of the RUN domain of the RAP2-interacting protein x

Crystal structure of the human receptor activity-modifying protein 1 extracellular domain

Crystal structure of the probable haloacid dehalogenase PH0459 from Pyrococcus horikoshii OT3.

Crystal structures of possible lysine decarboxylases from Thermus thermophilus HB8

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.

Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state

Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex

Identification of interaction site of pseudoazurin with its redox partner, copper-containing nitrite reductase from Alcaligenes faecalis S-6

Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures.

Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors

Immune regulatory functions of DOCK family proteins in health and disease

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes

Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression.

Site-directed mutagenesis of azurin from Pseudomonas aeruginosa enhances the formation of an electron-transfer complex with a copper-containing nitrite reductase from Alcaligenes faecalis S-6

Site-directed mutants of pseudoazurin: explanation of increased redox potentials from X-ray structures and from calculation of redox potential differences

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor

Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases

Structural basis for the specific recognition of the major antigenic peptide from the Japanese cedar pollen allergen Cry j 1 by HLA-DP5.

Structural basis of interleukin-5 dimer recognition by its α receptor

Structure of the UNC5H2 death domain.

TNIK inhibition abrogates colorectal cancer stemness

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.

Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities

The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain

X-ray structure and site-directed mutagenesis of a nitrite reductase from Alcaligenes faecalis S-6: roles of two copper atoms in nitrite reduction.