List of works by Robert Ballotti

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

scientific article

A new KIT mutation (N505I) in acral melanoma confers constitutive signaling, favors tumorigenic properties, and is sensitive to imatinib.

scientific article

Activation and regulation of the insulin receptor kinase

scientific article

Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity

scientific article published on February 1992

Advances in melanoma senescence and potential clinical application.

scientific article published on 11 January 2011

Antibodies to insulin receptor tyrosine kinase stimulate its activity towards exogenous substrates without inducing receptor autophosphorylation.

scientific article published on June 1989

Antibodies to phosphotyrosine injected in Xenopus laevis oocytes modulate maturation induced by insulin/IGF-I.

scientific article published in July 1991

Antiphosphotyrosine antibodies modulate insulin receptor kinase activity and insulin action

scientific article published on 01 January 1989

Aurora B is regulated by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway and is a valuable potential target in melanoma cells

scientific article

BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes

scientific article

BRCA1 is a new MITF target gene.

scientific article

Biological and mathematical modeling of melanocyte development.

scientific article published in September 2011

CD271 is an imperfect marker for melanoma initiating cells.

scientific article

Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome

scientific article

Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth

scientific article

Comment on Elejalde syndrome and relationship with Griscelli syndrome

scientific article published on 01 February 2003

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

scientific journal article

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.

scientific article

Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor

scientific article

Cyclic AMP a key messenger in the regulation of skin pigmentation.

scientific article

Cyclic AMP promotes a peripheral distribution of melanosomes and stimulates melanophilin/Slac2-a and actin association

scientific article

Cystinosin is a melanosomal protein that regulates melanin synthesis

scientific article published on 30 May 2012

Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression

scientific article

Deregulated MITF sumoylation: A route to melanoma

scientific article published on 26 May 2017

Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia

scientific article

Direct regulation of the Microphthalmia promoter by Sox10 links Waardenburg-Shah syndrome (WS4)-associated hypopigmentation and deafness to WS2.

scientific article published on December 2000

E2F1 inhibition mediates cell death of metastatic melanoma.

scientific article published on 9 May 2018

Endothelial Cells Promote Pigmentation through Endothelin Receptor B Activation

scientific article published on 26 August 2015

Enhanced binding of poly(ADP-ribose)polymerase-1 and Ku80/70 to the ITGA2 promoter via an extended cytosine-adenosine repeat

scientific article

Erratum: Corrigendum: A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

scientific article published in Nature

Erratum: NF-kB2 induces senescence bypass in melanoma via a direct transcriptional activation of EZH2

scientific article published on 01 May 2016

Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma.

scientific article published on 24 January 2011

Expression of two types of receptor for insulin-like growth factors in human malignant glioma.

scientific article

FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cells ⬇️

scientific article

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells

scientific article published on 18 January 2021

Fifteen-year quest for microphthalmia-associated transcription factor target genes

scientific article

Fitting MITF regulation of PDE4D3 into the skin pigmentation puzzle

scientific article published on 4 November 2010

Focus on cutaneous and uveal melanoma specificities.

scientific article published in April 2017

Functional labeling of insulin receptor subunits in live cells. Alpha 2 beta 2 species is the major autophosphorylated form

scientific article published on 01 December 1989

Functional role of MITF phosphorylation. In vivo veritas?

scientific article published on 19 August 2009

GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells

scientific article

GLI2-mediated melanoma invasion and metastasis

scientific article

Glycogen Synthase Kinase 3β Is Activated by cAMP and Plays an Active Role in the Regulation of Melanogenesis

scientific article published in Journal of Biological Chemistry

HGF induces fibronectin matrix synthesis in melanoma cells through MAP kinase-dependent signaling pathway and induction of Egr-1.

scientific article

HVEM has a broader expression than PD-L1 and constitutes a negative prognostic marker and potential treatment target for melanoma

scientific article published on 25 September 2019

High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressiveness

scientific article published on 06 March 2016

Hypomelanosis, immunity, central nervous system: no more "and", not the end

scientific article published on 01 February 2003

Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells

scientific article published on 26 September 2011

Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells

scientific article published on 27 June 2005

IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin

scientific article published on 13 December 2007

Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase

scientific article published on May 1985

Identification of functional insulin receptors on membranes from an insulin-producing cell line (RINm5F).

scientific article published on March 1985

Identification of melanoma initiating cells: does CD271 have a future?

scientific article published in January 2015

Immunohistochemistry as a potential tool for routine detection of the NRAS Q61R mutation in patients with metastatic melanoma.

scientific article published on 7 February 2015

In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter

scientific article published on 01 April 1998

In vitro and in vivo anti-melanoma effects of ciglitazone.

scientific article

In vivo reflectance confocal microscopy of the skin: a noninvasive means of assessing body cystine accumulation in infantile cystinosis

scientific article

Increased CD271 expression by the NF-kB pathway promotes melanoma cell survival and drives acquired resistance to BRAF inhibitor vemurafenib

scientific article published on 27 October 2015

Inhibition of Rho is required for cAMP-induced melanoma cell differentiation.

scientific article published on June 1998

Inhibition of melanogenesis by the antidiabetic metformin

scientific article published on 22 April 2014

Inhibition of the Phosphatidylinositol 3-Kinase/p70S6-Kinase Pathway Induces B16 Melanoma Cell Differentiation

scientific article published in Journal of Biological Chemistry

Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation.

scientific article published on April 1998

Insulin Stimulates Phosphatidylinositol-3-Kinase activity in rat adipocytes

article

Insulin and orthovanadate stimulate multiple phosphotyrosine-containing serine kinases

scientific article published on 01 February 1992

Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice.

scientific article

Insulin receptor: tyrosine kinase activity and insulin action.

scientific article

Insulin stimulates tyrosine phosphorylation of its receptor beta-subunit in intact rat hepatocytes

scientific article published on January 1987

Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors

scientific article published on 01 May 1991

Insulin-like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase

scientific article

Interaction between heterologous receptor tyrosine kinases. Hormone-stimulated insulin receptors activate unoccupied IGF-I receptors.

scientific article published on December 1991

Interactions of human Myosin Va isoforms, endogenously expressed in human melanocytes, are tightly regulated by the tail domain

scientific article

Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae

scientific article

Involvement of FKHRL1 in melanoma cell survival and death.

scientific article

Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein.

scientific article published in July 1998

Is it time to test biguanide metformin in the treatment of melanoma?

scientific article published on 26 June 2014

Low-dose vemurafenib induces complete remission in a case of hairy-cell leukemia with a V600E mutation.

scientific article published on 8 January 2013

Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma

scientific article

Meeting report from the Society for Melanoma Research 2012 Congress, Hollywood, California.

scientific article published on 13 May 2013

Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants

scientific article published on April 1989

Metformin blocks melanoma invasion and metastasis development in AMPK/p53-dependent manner.

scientific article published on 5 June 2013

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.

scientific article

Metformin monotherapy in melanoma: a pilot, open-label, prospective, and multicentric study indicates no benefit.

scientific article published on 25 January 2017

Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway.

scientific article published in October 2003

Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes

scientific article

Microphthalmia-associated transcription factor (MITF) is required but is not sufficient to induce the expression of melanogenic genes

scientific article

Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas.

scientific article published on 13 April 2010

Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport

scientific article

Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny.

scientific article published on 31 January 2011

Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells

scientific article published on 01 October 1995

NF-kB2 induces senescence bypass in melanoma via a direct transcriptional activation of EZH2.

scientific article published on 14 September 2015

NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model

scientific article published on 22 April 2015

Neprilysin, a novel target for ultraviolet B regulation of melanogenesis via melanocortins

scientific article published on 01 September 2000

Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis

scientific article published on February 1997

PGJ2 restores RA sensitivity in melanoma cells by decreasing PRAME and EZH2.

scientific article

PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes

scientific article published in October 2004

Pathways from senescence to melanoma: focus on MITF sumoylation.

scientific article published on 21 August 2017

Phenylarsine oxide stimulates a cytosolic tyrosine kinase activity and glucose transport in mouse fibroblasts

scientific article published on December 1991

Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype.

scientific article published on 22 March 2018

Presence of an insulin-stimulated serine kinase in cell extracts from IM-9 cells

scientific article published on 01 August 1986

Rab27a: A key to melanosome transport in human melanocytes

scientific article

Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate. Involvement of different serine/threonine kinases

scientific article published on December 1990

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

scientific article

Receptors for insulin-like growth factors in the central nervous system: structure and function.

scientific article

Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy

scientific article

Regulation of the microphthalmia-associated transcription factor gene by the Waardenburg syndrome type 4 gene, SOX10.

scientific article published on October 2000

Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product

scientific article

SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells

scientific article

SOX9 is a key player in ultraviolet B-induced melanocyte differentiation and pigmentation

scholarly article

SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.

scientific article published on 20 June 2011

SPARC represses E-cadherin and induces mesenchymal transition during melanoma development

scientific article published on August 2006

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype

scientific article published on December 2013

Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)

scientific article

Signal transduction by a chimeric insulin-like growth factor-1 (IGF-1) receptor having the carboxyl-terminal domain of the insulin receptor

scientific article published on April 1994

Signalling and chemosensitivity assays in melanoma: is mutated status a prerequisite for targeted therapy?

scientific article published on 01 December 2011

Solar ultraviolet light activates extracellular signal-regulated kinases and the ternary complex factor in human normal keratinocytes.

scientific article published in February 1998

Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest

scientific article published on 17 March 2009

TFE3, a transcription factor homologous to microphthalmia, is a potential transcriptional activator of tyrosinase and TyrpI genes

scientific article

The cleavage of microphthalmia-associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis

scientific article published on September 2005

The epithelial-mesenchymal transition (EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and AKT in promoting melanoma cell invasion

scientific article

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro

scientific article

The insulin receptor kinase

scientific article published on 01 October 1985

The insulin receptor: mechanism of activation and message transmission

scientific article

The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression.

scientific article

Transcriptional Analysis of Vitiligo Skin Reveals the Alteration of WNT Pathway: A Promising Target for Repigmenting Vitiligo Patients

scientific article published on 31 August 2015

Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation.

scientific article published on October 1990

Tumor necrosis factor alpha-mediated inhibition of melanogenesis is dependent on nuclear factor kappa B activation

scientific article published on February 1999

Tumor-Derived Fibronectin Is Involved in Melanoma Cell Invasion and Regulated by V600E B-Raf Signaling Pathway

scientific article published on 07 September 2006

Tyrosine and threonine phosphorylation of an immunoaffinity-purified 44-kDa MAP kinase

scientific article published on 01 September 1991

Tyrosine kinase activity of a chimeric insulin-like-growth-factor-1 receptor containing the insulin receptor C-terminal domain. Comparison with the tyrosine kinase activities of the insulin and insulin-like-growth-factor-1 receptors using a cell-fre

scientific article published on March 1995

Ultraviolet B radiation acts through the nitric oxide and cGMP signal transduction pathway to stimulate melanogenesis in human melanocytes

scientific article

Uncovering and deciphering the pro-invasive role of HACE1 in melanoma cells.

scientific article published on 7 March 2018

Up-regulation of MET Expression by α-Melanocyte-stimulating Hormone and MITF Allows Hepatocyte Growth Factor to Protect Melanocytes and Melanoma Cells from Apoptosis

scientific article published in Journal of Biological Chemistry

ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors

scientific article published on 05 September 2016

[Hypoxia inducible factor 1a is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells]

scientific article published on 01 January 2006

[Insulin receptor and action mechanism of the hormone]

scientific article published on 01 January 1989

[Insulin receptors: activators and signalling]

scientific article published on 01 January 1993

miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma.

scientific article

{alpha}MSH and Cyclic AMP elevating agents control melanosome pH through a protein kinase A-independent mechanism.

scientific article published on 22 April 2009

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