List of works by Marc Litaudon

(+)- and (-)-Ecarlottones, Uncommon Chalconoids from Fissistigma latifolium with Pro-Apoptotic Activity

scientific article published on 21 November 2017

(+)-Kunstlerone, a new antioxidant neolignan from the Leaves of Beilschmiedia kunstleri gamble. ⬇️

scientific article published on 4 August 2011

(+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees ⬇️

scientific article

(6,7-Dimethoxy-4-methylisoquinolinyl)-(4'-methoxyphenyl)-methanone, a new benzylisoquinoline alkaloid from Beilschmiedia brevipes ⬇️

scientific article

3′,4′-Dihydronorstephasubine, a New Bisbenzylisoquinoline from the Bark of Alseodaphne corneri

scientific article published on 31 July 2009

4-Deoxyphorbol inhibits HIV-1 infection in synergism with antiretroviral drugs and reactivates viral reservoirs through PKC/MEK activation synergizing with vorinostat

scientific article published on 26 March 2020

4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity.

scientific article published on 25 September 2010

A Dimeric sesquiterpenoid from a Malaysian Meiogyne as a new inhibitor of Bcl-xL/BakBH3 domain peptide interaction

scientific article published in March 2009

A New Pyranoacridone Alkaloid from the Bark of Medicosma subsessilis (Rutaceae)

scientific article published on 2 August 2018

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds. ⬇️

scientific article published on 14 October 2010

A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

scientific article published on 19 December 2015

A tocotrienol series with an oxidative terminal prenyl unit from Garcinia amplexicaulis

scientific article published on 13 November 2014

Acetylcholinesterase inhibitors from the leaves of Macaranga kurzii

scientific article published on 07 November 2012

Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors

scientific article published on 05 May 2014

Acylated farnesyl diglycosides from Guioa crenulata ⬇️

scientific article published on 3 November 2005

Acylphenols and dimeric acylphenols from Myristica maxima Warb

scientific article published on 09 April 2016

Acylphenols from Myristica crassa as new acetylcholinesterase inhibitors.

scientific article published on 31 July 2008

Advanced Structural Determination of Diterpene Esters Using Molecular Modeling and NMR Spectroscopy.

scientific article

Advanced glycation inhibition and protection against endothelial dysfunction induced by coumarins and procyanidins from Mammea neurophylla.

scientific article published on 13 April 2014

Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors

scientific article published on 3 November 2011

Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions.

scientific article published on 23 March 2016

Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species.

scientific article

Anti-diabetic and lipid-lowering effects of drimane sesquiterpenoids isolated from Zygogynum pancheri

scientific article published on 27 June 2020

Antiangiogenic tocotrienol derivatives from Garcinia amplexicaulis.

scientific article

Antibacterial Labdane Diterpenoids from Vitex vestita

scientific article published on 2 June 2015

Antileishmanial polyphenols from Garcinia vieillardii

scientific article published on 09 August 2007

Antioxidant and α-amylase inhibitory activities of extract and isolates from Zygogynum pancheri subsp. arrhantum.

scientific article

Antioxidant xanthones from Garcinia vieillardii

scientific article published in April 2004

Antiplasmodial alkaloids from Desmos rostrata

scientific article published on 01 December 2008

Antiplasmodial and antioxidant isoquinoline alkaloids from Dehaasia longipedicellata

scientific article published on 10 April 2014

Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).

scientific article published on 29 March 2010

Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae). ⬇️

scientific article published on 4 December 2008

Antiplasmodial, Anti-chikungunya virus and Antioxidant Activities of 64 endemic Plants from the Mascarene Islands

article

Antiplasmodial, antitrypanosomal, and cytotoxic activities of prenylated flavonoids isolated from the stem bark of Artocarpus styracifolius

scientific article published on 8 April 2010

Antiscalant properties of Herniaria glabra aqueous solution

Antitumor Polyether Macrolides: New and Hemisynthetic Halichondrins from the New Zealand Deep-Water SpongeLissodendoryxsp.

scholarly article published by Marc Litaudon in 2002

Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication

scientific article published on 13 May 2015

Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata ⬇️

scientific article published on 6 May 2015

Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach

scientific article published on 25 January 2019

Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri

scientific article published on 29 August 2012

Benzofurans from Styrax agrestis as acetylcholinesterase inhibitors: structure-activity relationships and molecular modeling studies

scientific article published on 22 September 2011

Betulinic Acid, The First Lupane-Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist.

scientific article published on 27 August 2016

Bioactive natural products prioritization using massive multi-informational molecular networks

scientific article

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.

scientific article published on 2 March 2018

Biodiversity as a Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Bioguided fractionation and isolation of natural inhibitors of advanced glycation end-products (AGEs) from Calophyllum flavoramulum

scientific article published on 23 March 2012

Biologically active tetralones from New Caledonian Zygogynum spp.

scientific article

Bisindole alkaloid artifacts from Gonioma malagasy

scientific article published on 18 January 2013

Bisnicalaterines B and C, atropisomeric bisindole alkaloids from Hunteria zeylanica, showing vasorelaxant activity

scientific article published in June 2010

CANPA: Computer-Assisted Natural Products Anticipation

scientific article published on 29 April 2019

CANPA: Computer-Assisted Natural Products Anticipation ⬇️

scientific article published on 15 August 2019

Can molecular networking be a powerful tool to target specific bioactive scaffolds? Case study of New Caledonian Euphorbiaceae species

Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors ⬇️

scientific article published on 20 July 2020

Ceramicines B-D, new antiplasmodial limonoids from Chisocheton ceramicus ⬇️

scientific article published on 24 November 2008

Chemical Constituents fromCroton insularis

article by Konstantia Graikou et al published 28 October 2005 in Helvetica Chimica Acta

Chemical constituents of Anacolosa pervilleana and their antiviral activities

scientific article published on 14 May 2012

Chemical diversity and antiviral potential in the pantropical Diospyros genus.

scientific article published on 25 April 2016

Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).

scientific article published on 21 July 2016

Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton

scientific article published on 7 June 2011

Collected mass spectrometry data on monoterpene indole alkaloids from natural product chemistry research

scientific article published on 03 April 2019

Correction to Advanced Structural Determination of Diterpene Esters Using Molecular Modeling and NMR Spectroscopy

scientific article published on 8 December 2015

Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line

scientific article

Cytotoxic Alkaloids from Leaves of Pilea aff. martinii

scientific article published on 21 February 2019

Cytotoxic Clerodane Diterpenoids from the Leaves of Casearia grewiifolia

scientific article published on 30 October 2015

Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius

scientific article published on 13 October 2019

Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius

scientific article

Cytotoxic aryltetralin lignans from fruits of Cleistanthus indochinensis

scientific article

Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum

scientific article

Cytotoxic farnesyl glycosides from Pittosporum pancheri

scientific article

Cytotoxic lignans from fruits of Cleistanthus indochinensis: synthesis of cleistantoxin derivatives

scientific article published on 31 August 2012

Cytotoxic lignans from fruits of Cleistanthus tonkinensis

scientific article published on 21 November 2019

Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction.

scientific article published in July 2009

Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata

scientific article published on 11 July 2019

Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata.

scientific article

Cytotoxic prenylated isoflavone and bipterocarpan from Millettia pachyloba

scientific article published on 22 April 2010

Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest

scientific article published on 27 February 2009

Cytotoxic steroidal alkaloids from Kibatalia laurifolia

scientific article published on 28 March 2011

Cytotoxic turrianes of Kermadecia elliptica from the New Caledonian rainforest

scientific article published on 7 September 2007

Diarylheptanoid Glucosides from Pyrostria major and Their Antiprotozoal Activities

Dual Beam Depth Profiling and Imaging with Argon and Bismuth Clusters of Prenylated Stilbenes on Glandular Trichomes of Macaranga vedeliana.

scientific article

Dunaliine A, a new amino diketone from Desmos dunalii (Annonaceae).

scientific article published in January 2009

Endiandric acid analogues from Beilschmiedia ferruginea as dual inhibitors of Bcl-xL/Bak and Mcl-1/Bid interactions

scientific article

Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata.

scientific article published on 19 September 2017

Enyne- and enediyne-γ-lactones from the bark of Meiogyne cylindrocarpa

scientific article published on 7 September 2011

Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity

scientific article published on 27 October 2016

Evaluation of Green Corrosion Inhibition by Alkaloid Extracts of Ochrosia oppositifolia and Isoreserpiline against Mild Steel in 1 M HCl Medium

Evaluation of Jatrophane Esters from Euphorbia spp. as Modulators of Candida albicans Multidrug Transporters.

scientific article published on 20 January 2017

First 2-hydroxy-3-methylbut-3-enyl substituted xanthones isolated from plants: structure elucidation, synthesis and antifungal activity.

scientific article published in June 2003

Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi

scientific article published on 22 March 2012

Goniomedines A and B: unprecedented bisindole alkaloids formed through fusion of two indole moieties via a dihydropyran unit

scientific article published on 06 August 2012

Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis. ⬇️

scientific article

HPLC-ELSD Quantification and Centrifugal Partition Chromatography Isolation of 8-O-Acetylharpagide from Oxera coronata (Lamiaceae).

scientific article published on 28 December 2016

Haemolytic acylated triterpenoid saponins from Harpullia austro-caledonica

scientific article published on 01 April 2005

Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract

scientific article published on 25 September 2015

Innovative omics-based approaches for prioritisation and targeted isolation of natural products - new strategies for drug discovery

scientific article published on 01 June 2019

Insights on profiling of phorbol, deoxyphorbol, ingenol and jatrophane diterpene esters by high performance liquid chromatography coupled to multiple stage mass spectrometry

scientific article published on 13 October 2015

Integration of Molecular Networking and In-Silico MS/MS Fragmentation for Natural Products Dereplication.

scientific article

Integration of molecular networking & in-silico MS/MS fragmentation: a novel dereplication strategy in natural products chemistry

Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation

scientific article published on 05 June 2019

Isohomohalichondrin B, a new antitumour polyether macrolide from the New Zealand deep-water sponge Lissodendoryx sp.

scholarly article published by Marc Litaudon in 2002

Isolation and some properties of ciguatoxin

Isolation of Picrotoxanes from Austrobuxus carunculatus Using Taxonomy-Based Molecular Networking

scientific article published on 05 October 2020

Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking

scientific article

Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa

scientific article published on 29 August 2019

Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead

scientific article published on 13 June 2014

Kingianic acids A-G, Endiandric acid analogues from Endiandra kingiana

scientific article published on 31 January 2014

Kingianin A: a new natural pentacyclic compound from Endiandra kingiana

scientific article published on August 2010

Kingianins O-Q: Pentacyclic polyketides from Endiandra kingiana as inhibitor of Mcl-1/Bid interaction

scientific article published on 11 January 2016

Koniamborine, the first pyrano[3,2-b]indole alkaloid and other secondary metabolites from Boronella koniambiensis

scientific article published in July 2005

LC-MS²-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity

scientific article published on 4 July 2015

Lancifoliaine, a new bisbenzylisoquinoline from the bark of Litsea lancifolia ⬇️

scientific article published on 13 April 2011

Lepidotol A from Mesua lepidota Inhibits Inflammatory and Immune Mediators in Human Endothelial Cells

scientific article published on 24 August 2015

Lissoclinotoxin A, an antibiotic 1,2,3-trithiane derivative from the tunicate Lissoclinum perforatum.

scientific article published on 25 July 2002

Lissoclinotoxins: Antibiotic polysulfur derivatives from the tunicate Lissoclinum perforatum. Revised structure of lissoclinotoxin A

Looking for Actives in the Haystack: Merging HRMS<sup>2</sup>-Based Molecular Networking, Chemometrics, and <sup>13</sup>C NMR-Based Dereplication Approaches

scientific article published on 28 September 2024

MZmine 2 Data-Preprocessing To Enhance Molecular Networking Reliability.

scientific article

Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

scientific article published on 25 June 2019

Massive multi-informative molecular networks to mine New-Caledonian chemodiversity for antiviral compounds

MetGem software for the generation of molecular networks based on t-SNE algorithm

scientific article published on 14 November 2018

Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor

scientific article published on 19 February 2020

Molecular networking approach to detect new analogues of prenylated stilbenes from Macaranga spp

Morierinin: a new cytotoxic cucurbitacin from the leaves of Morierina montana Vieill

scientific article published on 01 August 2003

Morphinandienone alkaloids from Dehaasia longipedicellata

scientific article published in December 2004

N-cyanomethylnorboldine: a new aporphine isolated from Alseodaphne perakensis (Lauraceae) ⬇️

scientific article published on 20 April 2011

N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë

scientific article published on 17 October 2018

Natural Inhibitors of the RhoA-p115 Complex from the Bark of Meiogyne baillonii

scientific article published on 03 July 2018

Natural aristolactams and aporphine alkaloids as inhibitors of CDK1/cyclin B and DYRK1A.

scientific article published on 6 March 2013

Natural cholinesterase inhibitors from Myristica cinnamomea King

scientific article published on 17 May 2016

Natural indole butyrylcholinesterase inhibitors from Nauclea officinalis

scientific article published on 20 November 2014

Naucline, a new indole alkaloid from the bark of Nauclea officinalis.

scientific article published on 2 April 2012

Neolamarckines A and B, new indole alkaloids from Neolamarckia cadamba. ⬇️

scientific article published on January 2011

Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae).

scientific article published on 28 December 2011

New Phenyl Propanoids from Cryptocarya bracteolata

New alkaloids from Phoebe grandis (Nees) Merr

scientific article published on 01 May 2006

New alkaloids from Phoebe scortechinii

scientific article published on 01 July 2007

New and antifungal xanthones from Calophyllum caledonicum.

scientific article published in January 2002

New biologically active linear triterpenes from the bark of three new-caledonian Cupaniopsis species

scientific article published on 15 December 2004

New cytotoxic guttiferone analogues from Garcinia virgata from New Caledonia.

scientific article published on January 2006

New diterpenes from Croton insularis

scientific article published on 01 April 2004

New flavonoid and stilbene derivatives from the fruits of Macaranga balansae

scientific article published on 02 April 2019

New phenantrene alkaloids from Cryptocarya crassinervia

scientific article

New proaporphines from the bark of Phoebe scortechinii

scientific article published in January 2008

New secoiridoid from olive mill wastewater

scientific article

New xanthones from Calophyllum caledonicum

scientific article published on 01 November 2000

Non polar compounds from the bark of Sarcomelicope follicularis

scientific article published on 30 April 2003

Normal phase HPLC-based activity profiling of non-polar crude plant extracts - acetylcholinesterase inhibiting guttiferones from Montrouziera cauliflora as a case study

scientific article published on 26 April 2016

Novelseco-Dibenzopyrrocoline Alkaloid fromCryptocaryaoubatchensis

scientific article published on 01 August 2006

Oppositinines A and B: New Vasorelaxant .BETA.-Carboline Alkaloids from Neisosperma oppositifolia ⬇️

scientific article published on August 1, 2010

Optimized experimental workflow for tandem mass spectrometry molecular networking in metabolomics

scientific article

PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

article published in 2011

Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa ⬇️

scientific article published on 06 October 2020

Pahangine A and B, two new oxetane containing neolignans from the barks of Beilschmiedia glabra Kosterm (Lauraceae)

Pecrassipines A and B, Seco-Bisbenzylisoquinoline Alkaloids from Phaeanthus crassipetalus

scientific article published on 17 February 2009

Pentacyclic polyketides from Endiandra kingiana as inhibitors of the Bcl-xL/Bak interaction

scientific article published on 05 May 2011

Plumbagin from Diospyros olen ⬇️

scientific article published on 6 December 2011

Prenylated flavonoids and other constituents from Macaranga indica

scientific article published on 09 September 2019

Preparative isolation, fast centrifugal partition chromatography purification and biological activity of cajaflavanone from Derris ferruginea stems

scientific article

Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2

scientific article published on 03 February 2020

Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1.

scientific article published on 6 September 2014

Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication

scientific article published on 7 December 2012

Quick identification of kuraridin, a noncytotoxic anti-MRSA (methicillin-resistant Staphylococcus aureus) agent from Sophora flavescens using high-speed counter-current chromatography.

scientific article

Quinine- and quinicine-derived alkaloids from Guettarda noumeana

scientific article published on 25 July 2002

Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors.

scientific article

Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.

scientific article published in June 2010

Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of Geissospermum laeve.

scientific article

Saponins from Strasburgeria robusta

scientific article published on 01 June 2001

Sarcodifurines A and B, Two New Furoquinolines from Sarcomelicope follicularis ⬇️

scientific article published on 5 March 2009

Searching for original natural products by molecular networking: detection, isolation and total synthesis of chloroaustralasines

scientific article published in 2018

Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.

scientific article published on 10 June 2016

Sesquiterpenoids and cytotoxic lignans from the bark of Libocedrus chevalieri

scientific article published on 04 August 2007

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

scientific article (publication date: 9 August 2016)

Structurally Diverse Diterpenoids from Sandwithia guyanensis.

scientific article published in March 2018

Structure Reassignment of Melonine and Quantum-Chemical Calculations-Based Assessment of Biosynthetic Scenarios Leading to Its Revised and Original Structures

scientific article published on 16 July 2021

Structure elucidation of an aspidofractinine-type monoterpene indole alkaloid from Melodinus reticulatus

scientific article published on 16 February 2023

Styryllactones and acetogenins from the fruits of Goniothalamus macrocalyx

scientific article published in April 2014

Subditine, a new monoterpenoid indole alkaloid from bark of Nauclea subdita (Korth.) Steud. induces apoptosis in human prostate cancer cells

scientific article (publication date: 2014)

Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase

Thirteen New Xanthone Derivatives from (Clusiaceae) ⬇️

scientific article published on 31 January 2002

Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication

scientific article published on 28 May 2014

Tirucallane triterpenes from Dysoxylum macranthum

scientific article published on 25 July 2002

Tonantzitlolones from Stillingia lineata ssp. lineata as potential inhibitors of chikungunya virus

Toxicarioside M, a new cytotoxic 10β-hydroxy-19-nor-cardenolide from Antiaris toxicaria

scientific article

Trigocherrierin A, a potent inhibitor of chikungunya virus replication.

scientific article published on 24 March 2014

Trigocherrin A, the first natural chlorinated daphnane diterpene orthoester from Trigonostemon cherrieri ⬇️

scientific article published on 19 December 2011

Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae).

scientific article

Triterpenoid saponins and acylated prosapogenins from Harpullia austro-caledonica

scientific article published on 01 April 2002

Triterpenoid saponins from Symplocos lancifolia

scientific article published on 2 February 2011

Triterpenoid saponins from the stem bark of Elattostachys apetala

scientific article published on 01 June 2001

Turrianes from Kermadecia rotundifolia as new acetylcholinesterase inhibitors

scientific article published on 30 December 2009

Two new linear acetogenins from the fruits of Goniothalamus gracilipes

scientific article

Two new sesquiterpenes from the fruits of Fissistigma villosissimum

scientific article published on 21 June 2016

Tyrosinase inhibitors and sesquiterpene diglycosides from Guioa villosa

scientific article

Ugandenial A, a new drimane-type sesquiterpenoid from Warburgia ugandensis ⬇️

scientific article published on 28 September 2009

Xanthone and dihydroisocoumarin from Montrouziera sphaeroidea

scientific article published on 01 April 2000

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