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List of works by Richard Kuhn

A fast cross-validation method for alignment of electron tomography images based on Beer-Lambert law.

scientific article published on 5 October 2015

A heterologous coiled coil can substitute for helix I of the Sindbis virus capsid protein

scientific article

A human antibody against Zika virus crosslinks the E protein to prevent infection

scientific article (publication date: 16 March 2017)

A molecularly cloned, live-attenuated japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice

scientific article

A physical interaction network of dengue virus and human proteins

scientific article

A structural and functional perspective of alphavirus replication and assembly

scientific article

Alphavirus Nucleocapsid Packaging and Assembly

scientific article published on 20 March 2018

Alphavirus capsid protein helix I controls a checkpoint in nucleocapsid core assembly

scientific article

An investigation of phenylthiazole antiflaviviral agents ⬇️

scientific article published on May 3, 2011

Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E protein

scientific article

Association of sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly

scientific article

Aura virus structure suggests that the T=4 organization is a fundamental property of viral structural proteins

scientific article

Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins ⬇️

scientific article

Can an FDA-Approved Alzheimer's Drug Be Repurposed for Alleviating Neuronal Symptoms of Zika Virus?

scientific article published on 27 June 2017

Capturing a Flavivirus Pre-Fusion Intermediate

scientific article (publication date: November 2009)

Capturing a Virus while It Catches Its Breath ⬇️

scientific article published on February 8, 2012

Catalytic Core of Alphavirus Nonstructural Protein nsP4 Possesses Terminal Adenylyltransferase Activity

scientific article (publication date: October 2006)

Changes in the Proteome of Langat-Infected Ixodes scapularis ISE6 Cells: Metabolic Pathways Associated with Flavivirus Infection

scientific article

Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro

scientific article

Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking

scientific article

Characterization of the proteome of cytoplasmic lipid droplets in mouse enterocytes after a dietary fat challenge

scientific article

Closing the door on flaviviruses: Entry as a target for antiviral drug design

scientific article

Combined effects of the structural heterogeneity and dynamics of flaviviruses on antibody recognition

scientific article

Complexes of poliovirus serotypes with their common cellular receptor, CD155

scientific article

Construction and applications of yellow fever virus replicons.

scientific article published in January 2005

Coupling of replication and assembly in flaviviruses

scientific article

Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN.

scientific article

Cryo-EM structure of rhinovirus C15a bound to its cadherin-related protein 3 receptor

scientific article published on 09 March 2020

Cryo-electron tomography of rubella virus

scientific article

Crystal Structure of Aura Virus Capsid Protease and Its Complex with Dioxane: New Insights into Capsid-Glycoprotein Molecular Contacts ⬇️

scientific article published on December 14, 2012

Crystal Structure of Human Enterovirus 71 ⬇️

scientific article published on June 8, 2012

Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site.

scientific article

Crystallization and preliminary X-ray diffraction analysis of West Nile virus

scientific article

Crystallization, high-resolution data collection and preliminary crystallographic analysis of Aura virus capsid protease and its complex with dioxane

scientific article

Dengue structure differs at the temperatures of its human and mosquito hosts

scientific article

Dengue virus infection perturbs lipid homeostasis in infected mosquito cells

scientific article

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

scientific article

Design, expression, and purification of a Flaviviridae polymerase using a high-throughput approach to facilitate crystal structure determination

scientific article (publication date: October 2004)

Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins

scientific article

Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins

scientific article

Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein

scientific article

Development and Evaluation of an Enzyme-Linked Immunosorbent Assay for Dengue Capsid ⬇️

scientific article published on March 29, 2012

Development of novel antivirals against flaviviruses

scientific article published on January 2006

Die Struktur der blauen Pigmente vonCorynebacterium insidiosum, Arthrobacter atrocyaneus, Pseudomonas indigofera undArthrobacter crystallopoietes

scientific article published in 1964

Directed Evolution of a Virus Exclusively Utilizing Human Epidermal Growth Factor Receptor as the Entry Receptor ⬇️

scientific article published on August 7, 2013

Editorial overview: Virus structure and functions

scientific article published in June 2017

Enhancing dengue virus maturation using a stable furin over-expressing cell line

scientific article published on 12 July 2016

Enveloped viruses

scientific article

Extended surface for membrane association in Zika virus NS1 structure

scientific article

Faculty of 1000 evaluation for Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication

scholarly article published 23 August 2017

Flavivirus Capsid Is a Dimeric Alpha-Helical Protein

scientific article

Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System

scientific article

Flaviviruses have imperfect icosahedral symmetry

article published in the Proceedings of the National Academy of Sciences of the United States of America

Fluorescent Protein-Tagged Sindbis Virus E2 Glycoprotein Allows Single Particle Analysis of Virus Budding from Live Cells

scientific article

Functional Characterization of the Alphavirus TF Protein ⬇️

scientific article published on May 29, 2013

Functional Requirements of the Yellow Fever Virus Capsid Protein

scientific article (publication date: June 2007)

Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease.

scientific article published on 2 March 2007

Functional characterization of the Sindbis virus E2 glycoprotein by transposon linker-insertion mutagenesis

scientific article (publication date: 20 June 2007)

Heparin binding sites on Ross River virus revealed by electron cryo-microscopy

scientific article

Heterologous production, purification and characterization of enzymatically active Sindbis virus nonstructural protein nsP1

scientific article

Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms

scientific article

Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease

scientific article published on 01 July 2020

Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay

scientific article

Impact of Dengue Virus Infection on Global Metabolic Alterations in the Aedes aegypti Mosquito Vector

In vitro-assembled alphavirus core-like particles maintain a structure similar to that of nucleocapsid cores in mature virus

scientific article published on November 2002

Indigoidine and other bacterial pigments related to 3,3?-bipyridyl

scientific article published on 01 May 1965

Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses

scientific article

Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles

scientific article

Interactions of the Cytoplasmic Domain of Sindbis Virus E2 with Nucleocapsid Cores Promote Alphavirus Budding ⬇️

scientific article published on December 21, 2011

Locations of carbohydrate sites on alphavirus glycoproteins show that E1 forms an icosahedral scaffold

scientific article published on April 2001

Locking and Blocking the Viral Landscape of an Alphavirus with Neutralizing Antibodies

scientific article

Mapping the Structure and Function of the E1 and E2 Glycoproteins in Alphaviruses

scientific article (publication date: 2006)

Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres

scientific article

Membrane curvature in flaviviruses ⬇️

scientific article published on April 18, 2013

Molecular Links between the E2 Envelope Glycoprotein and Nucleocapsid Core in Sindbis Virus ⬇️

scientific article published on October 4, 2011

Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354 ⬇️

scientific article published on October 18, 2010

Neutralizing antibodies can initiate genome release from human enterovirus 71

scientific article

Novel approaches to flavivirus drug discovery ⬇️

scientific article published on March 22, 2012

Phototoxicity against tumor cells and Sindbis virus by an octahedral rhodium bisbipyridyl complex and evidence for the genome as a target in viral photoinactivation

scientific article published in August 2004

Picornavirus-receptor interactions

scientific article

Placement of the structural proteins in Sindbis virus

scientific article

Probing the Early Temporal and Spatial Interaction of the Sindbis Virus Capsid and E2 Proteins with Reverse Genetics ⬇️

scientific article published on September 5, 2012

RNAi reveals proteins for metabolism and protein processing associated with Langat virus infection in Ixodes scapularis (black-legged tick) ISE6 cells

scientific article published on 13 January 2017

Rapid detection of dengue virus in serum using magnetic separation and fluorescence detection

scientific article

Reactive oxygen species formation by UV-A irradiation of urocanic acid and the role of trace metals in this chemistry

scientific article published in December 2003

Rescue of Infectious Particles from Preassembled Alphavirus Nucleocapsid Cores ⬇️

scientific article published on April 6, 2011

Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection

scientific article published on 21 May 2008

Role of sindbis virus capsid protein region II in nucleocapsid core assembly and encapsidation of genomic RNA.

scientific article published on 27 February 2008

Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host

scientific article

Simultaneous determination of sample thickness, tilt, and electron mean free path using tomographic tilt images based on Beer-Lambert law.

scientific article published on 30 September 2015

Sindbis virus nucleocapsid assembly: RNA folding promotes capsid protein dimerization

scientific article published on January 2004

Single-step antibody-based affinity cryo-electron microscopy for imaging and structural analysis of macromolecular assemblies

scientific article

Solution structure of dengue virus capsid protein reveals another fold

scholarly article

Spatial and Temporal Analysis of Alphavirus Replication and Assembly in Mammalian and Mosquito Cells

scientific article published on 14 February 2017

Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development

scientific article (publication date: 11 September 2008)

Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody

scientific article (publication date: 21 October 2009)

Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structural biology of Zika virus and other flaviviruses

scientific article published on 8 January 2018

Structural changes of envelope proteins during alphavirus fusion ⬇️

scientific article published on December 2, 2010

Structural proteomics of dengue virus

scientific article

Structure and inhibition of EV-D68, a virus that causes respiratory illness in children

scientific article

Structure determination of enterovirus 71

scientific article

Structure of Immature West Nile Virus

scientific article (publication date: June 2007)

Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers

scientific article published on 29 October 2014

Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex

scientific article

Structure of dengue virus: implications for flavivirus organization, maturation, and fusion

scientific article

Structure of human enterovirus 71 in complex with a capsid-binding inhibitor ⬇️

scientific article published on March 18, 2013

Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing

scientific article

Structure of the immature Zika virus at 9 Å resolution

scientific article (publication date: 9 January 2017)

Structure of the immature dengue virus at low pH primes proteolytic maturation

scientific article

Structure-guided insights on the role of NS1 in flavivirus infection

scientific article

Structures of immature flavivirus particles

scientific article

Struktur und Synthesen des Bakterienfarbstoffs Indigoidin

scientific article published on 01 July 1965

Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication

scientific article

The 3.8 Å resolution cryo-EM structure of Zika virus

scientific article

The Coiled-coil Domain Structure of the Sin Nombre Virus Nucleocapsid Protein

scientific article

The Zika virus envelope protein glycan loop regulates virion antigenicity

scientific article published on 2 January 2018

The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.

scientific article published on July 2005

The flavivirus precursor membrane-envelope protein complex: structure and maturation

scientific article

The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation

scholarly article

Ultrastructural analysis of hepatitis C virus particles ⬇️

scientific article published on May 20, 2013

Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells

scientific article

Visualization of membrane protein domains by cryo-electron microscopy of dengue virus

scientific article

West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody

scientific article (publication date: 15 August 2006)

West Nile virus methyltransferase domain interacts with protein kinase G.

scientific article published on 22 July 2013

Yellow Fever Virus NS3 Plays an Essential Role in Virus Assembly Independent of Its Known Enzymatic Functions

scientific article (publication date: April 2008)

Zika Virus Can Strongly Infect and Disrupt Secondary Organizers in the Ventricular Zone of the Embryonic Chicken Brain

scholarly article by Ankita Thawani et al published 17 April 2018 in Cell Reports

Zika Virus Structure, Maturation, and Receptors

scientific article published in December 2017

trans-Protease Activity and Structural Insights into the Active Form of the Alphavirus Capsid Protease

scientific article

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