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List of works by K. Ravi Acharya

A comparative bioinformatic analysis of C9orf72.

scientific article published on 19 February 2018

A critical evaluation of the predicted and X-ray structures of ?-Lactalbumin

scientific article published on 01 October 1990

A family of killer toxins. Exploring the mechanism of ADP-ribosylating toxins.

scientific article published on 5 September 2006

A new high-resolution crystal structure of the Drosophila melanogaster angiotensin converting enzyme homologue, AnCE.

scientific article published on 11 August 2015

A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarity

scientific article published on 01 June 1997

ACE for all - a molecular perspective

scientific article

Ace revisited: a new target for structure-based drug design.

scientific article

Activator anion binding site in pyridoxal phosphorylase b: the binding of phosphite, phosphate, and fluorophosphate in the crystal.

scientific article

Alpha-lactalbumin possesses a novel calcium binding loop.

scientific article

Amino acid sequence and crystal structure of buffalo alpha-lactalbumin

scientific article published on 01 September 1996

Analysis and characterization of data from twinned crystals.

scientific article

Angiotensin-I converting enzyme (ACE): structure, biological roles, and molecular basis for chloride ion dependence

scientific article published on October 2014

Angiotensin-converting enzyme open for business: structural insights into the sub-domain dynamics

scientific article published on 17 October 2020

Binding of non-natural 3'-nucleotides to ribonuclease A.

scientific article published in February 2005

Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography

scientific article

Biological and structural features of murine angiogenin-4, an angiogenic protein

scientific article

C9orf72, a protein associated with amyotrophic lateral sclerosis (ALS) is a guanine nucleotide exchange factor

scientific article published on 17 October 2018

Channels at the catalytic site of glycogen phosphorylase b: binding and kinetic studies with the beta-glycosidase inhibitor D-gluconohydroximo-1,5-lactone N-phenylurethane

scientific article published on 01 September 1988

Characterisation, crystallisation and preliminary X-ray diffraction analysis of a Fab fragment of a rat monoclonal antibody with very high affinity for the human muscle acetylcholine receptor

scientific article published on 01 July 1996

Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.

scientific article

Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis

scientific article published on 23 January 2020

Cleavage of 3',5'-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin

scientific article

Cloning, expression and purification of the CCN family of proteins in Escherichia coli

scientific article published on 31 March 2011

Conformational changes induced by binding UDP-2F-galactose to alpha-1,3 galactosyltransferase- implications for catalysis

scientific article

Control of phosphorylase b conformation by a modified cofactor: crystallographic studies on R-state glycogen phosphorylase reconstituted with pyridoxal 5'-diphosphate ⬇️

scientific article published on September 1, 1992

Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site ⬇️

scientific article published on 2 April 2015

Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A

scientific article

Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1).

scientific article published on 4 August 2004

Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor

scientific article

Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster

scientific article

Crystal structure of alpha-1,3-galactosyltransferase (alpha3GT) in a complex with p-nitrophenyl-beta-galactoside (pNPbetaGal)

scientific article

Crystal structure of botulinum neurotoxin subtype A3 cell binding domain in complex with GD1a co-receptor ganglioside

scientific article published on 28 January 2020

Crystal structure of bovine angiogenin at 1.5-A resolution

scientific article

Crystal structure of eosinophil cationic protein at 2.4 A resolution

scientific article

Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins

scientific article

Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule

scientific article

Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent

scientific article published on February 2005

Crystal structure of human α-lactalbumin at 1·7 Å resolution

scientific article published on 01 September 1991

Crystal structure of peptide-bound neprilysin reveals key binding interactions

scientific article published on 21 September 2019

Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.

scientific article published on 31 January 2006

Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1.

scientific article

Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site ⬇️

scientific article published on August 15, 1995

Crystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragment

scientific article

Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose.

scientific article

Crystal structures of angiotensin-converting enzyme from Anopheles gambiae in its native form and with a bound inhibitor

scientific article published on 01 November 2019

Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A.

scientific article published in January 2006

Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase

scientific article

Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme

scientific article

Crystal structures of murine angiogenin-2 and -3 - probing ‘structure - function’ relationships amongst angiogenin homologues

scientific article

Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine

scientific article (publication date: May 2003)

Crystal structures of ribonuclease A complexes with 5'-diphosphoadenosine 3'-phosphate and 5'-diphosphoadenosine 2'-phosphate at 1.7 A resolution

scientific article

Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity.

scientific article published on 24 February 2018

Crystallization and preliminary X-ray analysis of a microbial superantigen staphylococcal enterotoxin C2

scientific article published on 01 September 1993

Crystallization and preliminary X-ray analysis of human angiogenin

scientific article published on 01 December 1992

Crystallization and preliminary crystallographic study of an Fab fragment of a pathogenic rat monoclonal antibody against the nicotinic acetylcholine receptor.

scientific article

Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase b

scientific article

Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency

scientific article

Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro.

scientific article

Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide.

scientific article published on 19 February 2015

Cwp84, a surface-associated cysteine protease, plays a role in the maturation of the surface layer of Clostridium difficile.

scientific article published on 6 October 2009

Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.

scientific article published on April 2003

Engineered botulinum neurotoxins as new therapeutics

scientific article published on 30 August 2013

Engineering botulinum neurotoxin domains for activation by toxin light chain.

scientific article published on 23 December 2011

Engineering toxins for 21st century therapies.

scientific article published on 3 February 2011

Eosinophil granule proteins: form and function

scientific article published on 06 May 2014

Expression, purification and cell cytotoxicity of actin-modifying binary toxin from Clostridium difficile.

scientific article

Expression, purification, crystallization and preliminary crystallographic analysis of a putative Clostridium difficile surface protein Cwp19

scientific article

Family 6 glycosyltransferases in vertebrates and bacteria: inactivation and horizontal gene transfer may enhance mutualism between vertebrates and bacteria.

scientific article published on 24 September 2010

First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.

scientific article published in May 2005

First structural glimpse of CCN3 and CCN5 multifunctional signaling regulators elucidated by small angle x-ray scattering.

scientific article published on 4 May 2011

Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors

scientific article

From lysozyme to α-lactalbumin: protein engineering and evolution

scientific article published on 01 August 1987

Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin.

scientific article published on 11 August 2016

Guest-host crosstalk in an angiogenin-RNase A chimeric protein

scientific article

High resolution crystal structure of substrate-free human neprilysin

scientific article published on 12 June 2018

High resolution crystal structures of Clostridium botulinum neurotoxin A3 and A4 binding domains.

scientific article

High resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6

scientific article published on 11 July 2020

High resolution crystal structures of the receptor-binding domain of Clostridium botulinum neurotoxin serotypes A and FA.

scientific article published on 21 March 2018

High-resolution crystal structures of Drosophila melanogaster angiotensin-converting enzyme in complex with novel inhibitors and antihypertensive drugs

scientific article

Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template

scientific article

How a DNA mimic catches and cleaves NF-κB

scientific article published in Journal of Biological Chemistry

Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons.

scientific article

Human dendritic cells conditioned with Staphylococcus aureus enterotoxin B promote TH2 cell polarization

scientific article published on 04 April 2006

Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2. Implications for superantigen recognition

scientific article

Identification of placenta growth factor determinants for binding and activation of Flt-1 receptor.

scientific article published on 21 July 2004

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

scholarly article

Influence of naturally-occurring 5â ²-pyrophosphate-linked substituents on the binding of adenylic inhibitors to ribonuclease a: An X-ray crystallographic study

scientific article

Interkingdom Pharmacology of Angiotensin-I Converting Enzyme Inhibitor Phosphonates Produced by Actinomycetes

scientific article

Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme

scientific article published on 25 January 2018

Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme.

scientific article published on 08 January 2016

Models of the three-dimensional structures of echidna, horse, and pigeon lysozymes: Calcium-binding lysozymes and their relationship with α-lactalbumins

scientific article published on 01 August 1994

Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-domain - Implications for Drug Design

scientific article published on 07 November 2018

Molecular and Thermodynamic Mechanisms of the Chloride-dependent Human Angiotensin-I-converting Enzyme (ACE)

scientific article

Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile

scientific article published on 16 August 2019

Molecular features of the sortase enzyme family

scientific article

Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution.

scientific article

Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor

scientific article (publication date: April 2005)

N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.

scientific article

Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide

scientific article

Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa.

scientific article published on 6 January 2016

Phosphate-recognition sites in catalysis and control of glycogen phosphorylaseb

scientific article published on 01 October 1987

Prediction of structural consequences for disease causing variants in C21orf2 protein using computational approaches

scientific article published on 17 January 2018

Purification, crystallization and preliminary X-ray analysis of toxic shock syndrome toxin-1 from Staphylococcus aureus

scientific article published on 01 December 1992

Ribonuclease A Homologues of the Zebrafish: Polymorphism, Crystal Structures of Two Representatives and their Evolutionary Implications

scientific article

Role of conserved residues in structure and stability: Tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily ⬇️

scientific article

Role of glutamine-117 in the ribonucleolytic activity of human angiogenin.

scientific article (publication date: 12 April 1994)

Roles of active site tryptophans in substrate binding and catalysis by alpha-1,3 galactosyltransferase.

scientific article

Roles of individual enzyme-substrate interactions by alpha-1,3-galactosyltransferase in catalysis and specificity

scientific article

Screening a limited structure-based library identifies UDP-GalNAc-specific mutants of alpha-1,3-galactosyltransferase

scientific article

Selective Recognition of Mannose by the Human Eosinophil Charcot-Leyden Crystal Protein (Galectin-10): A Crystallographic Study at 1.8 Å Resolution

scientific article

Special issue: engineering toxins for 21st-century therapies: introduction

scientific article published on 03 November 2011

Spectroscopic and structural analysis of somatic and N-domain angiotensin I-converting enzyme isoforms from mesangial cells from Wistar and spontaneously hypertensive rats.

scientific article published on 8 May 2010

Structural Basis for Substrate Recognition in the Enzymatic Component of ADP-ribosyltransferase Toxin CDTa from Clostridium difficile

scientific article

Structural Insights into the Binding of Vascular Endothelial Growth Factor-B by VEGFR-1D2: RECOGNITION AND SPECIFICITY

scientific article

Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons

scientific article

Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb)

scientific article published on 31 May 2019

Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme

scientific article

Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7

scientific article

Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase

scientific article

Structural basis of substrate specificity in porcine RNase 4

scientific article

Structural changes in glycogen phosphorylase induced by phosphorylation

scientific article published in Nature

Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme.

scientific article published in July 2004

Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin

scientific article

Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis

scientific article

Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B

scientific article

Structure and function of a Clostridium difficile sortase enzyme

scientific article

Structure based drug design of angiotensin-I converting enzyme inhibitors.

scientific article published on January 2012

Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus

scientific article

Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen

scientific article

Structure of angiotensin I-converting enzyme.

scientific article

Structure of mouse IP-10, a chemokine

scientific article

Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies.

scientific article published on 19 November 2005

Super toxins from a super bug: structure and function of Clostridium difficile toxins.

scientific article published on June 2011

Superantigens as immunomodulators: recent structural insights ⬇️

scientific article published on August 15, 1997

The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme

scientific article

The advantages and limitations of protein crystal structures.

scientific article

The binding of 2-deoxy-D-glucose 6-phosphate to glycogen phosphorylase b: kinetic and crystallographic studies

scientific article

The catalytic activity and secretion of zebrafish RNases are essential for their in vivo function in motor neurons and vasculature

scientific article published in Scientific Reports

The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site

scientific article

The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution

scientific article

The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile

scientific article published on 30 October 2017

The structure of the S-layer of Clostridium difficile.

scientific article published on 23 November 2017

The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein fromClostridium difficile

scientific article

The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae ⬇️

scientific article (publication date: 27 March 2017)

Toward rational design of ribonuclease inhibitors: high-resolution crystal structure of a ribonuclease A complex with a potent 3',5'-pyrophosphate-linked dinucleotide inhibitor

scientific article

Tying the knot: the cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines.

scientific article published on 7 October 2011

Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics

scientific article published on 20 October 2018

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