List of works - David O'Hagan

A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic [18 F]Fluorination for PET Imaging.

scientific article published on 29 August 2017

A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions.

scientific article published on 2 July 2014

A two-step fluorinase enzyme mediated (18)F labelling of an RGD peptide for positron emission tomography.

scientific article published on 29 July 2015

Acetyl Coenzyme A Analogues as Rationally Designed Inhibitors of Citrate Synthase

scientific article published on 29 March 2019

All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane

scientific article published on 13 April 2015

An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

scientific article published on 31 July 2019

Analysis of CF···FC Interactions on Cyclohexane and Naphthalene Frameworks

article

Bis(trifluoromethyl)methylene addition to vinyl-terminated SAMs: a gas-phase C-C bond-forming reaction on a surface.

scientific article

Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells.

scientific article published on 3 February 2016

Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of α(v)β(3) integrin receptor.

scientific article published on July 2013

Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging

scientific article published on 08 August 2018

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

scientific article published on 01 February 2019

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase

scientific article published on 24 February 2016

Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme

scientific article

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

scientific article published on 03 May 2015

Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate ⬇️

scientific article published on September 20, 2010

Fluorinated Musk Fragrances: The CF2 Group as a Conformational Bias Influencing the Odour of Civetone and (R)-Muscone.

scientific article published on 6 May 2016

Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif. ⬇️

scientific article published on 19 April 2017

Fluorinated cyclopropanes: synthesis and chemistry of the aryl α,β,β-trifluorocyclopropane motif

scientific article published in 2018

Fluorinated liquid crystals: evaluation of selectively fluorinated facially polarised cyclohexyl motifs for liquid crystal applications.

scientific article published in October 2016

Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif

scientific article published in 2015

Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

scientific article published on 01 August 2019

Fluorine in fragrances: exploring the difluoromethylene (CF2) group as a conformational constraint in macrocyclic musk lactones

scientific article published in 2016

Fluorine-containing substituents: metabolism of the α,α-difluoroethyl thioether motif

scientific article published on 28 June 2019

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674.

scientific article

Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus

scientific article published on 01 December 2016

Hyperconjugation Is the Source of Helicity in Perfluorinated n-Alkanes

scientific article published on 31 May 2017

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid†

scientific article

Identification of fluorinases from streptomyces sp MA37, norcardia brasiliensis, and actinoplanes sp N902-109 by genome mining

scientific article

Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus ⬇️

scientific article published on 18 September 2017

Inter- and intramolecular CF···co interactions on aliphatic and cyclohexane carbonyl derivatives

scientific article published on 23 April 2015

Interaction of B12F122- with All-cis 1,2,3,4,5,6 Hexafluorocyclohexane in the Gas Phase

scientific article

Janus Face Aspect of All-cis 1,2,3,4,5,6-Hexafluorocyclohexane Dictates Remarkable Anion and Cation Interactions In the Gas Phase.

scientific article

Last-Step Enzymatic [(18) F]-Fluorination of Cysteine-Tethered RGD Peptides Using Modified Barbas Linkers

scientific article published on 04 July 2016

Lewis acid-promoted hydrofluorination of alkynyl sulfides to generate α-fluorovinyl thioethers.

scientific article published on 14 October 2015

Metabolism and hydrophilicity of the polarised 'Janus face' all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery.

scientific article

Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.

scientific article published on 9 April 2018

Multicomponent reactions of methyl substituted all-cis tetrafluorocyclohexane aldehydes.

scientific article published on 8 December 2015

Organic chemistry on surfaces: Direct cyclopropanation by dihalocarbene addition to vinyl terminated self-assembled monolayers (SAMs)

scientific article

Organo-fluorine chemistry III.

scientific article published on 23 October 2013

Organofluorine chemistry: Difluoromethylene motifs spaced 1,3 to each other imparts facial polarity to a cyclohexane ring.

scientific article published on 22 December 2016

Particularly strong C–H⋯π interactions between benzene and all-cis 1,2,3,4,5,6-hexafluorocyclohexane

article

Polar alicyclic rings: synthesis and structure of all cis-1,2,3,4-tetrafluorocyclopentane

scientific article published on 21 March 2016

Probing the helical integrity of multivicinal all-syn-fluoro alkanes

scientific article published on 16 January 2020

Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane

scientific article published on 21 December 2015

Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells.

scientific article published on 29 April 2017

Stepwise preparation of all-cis 1,3,4-trifluoro-2-phenylcyclohexane, avoiding a phenonium intermediate

scientific article published on 19 August 2014

Stereochemical outcomes of C-F activation reactions of benzyl fluoride.

scientific article published on 9 January 2018

Stereoselective alpha-fluoroamide and alpha-fluoro-gamma-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement.

scientific article published on 17 October 2005

Supramolecular packing of alkyl substituted Janus face all-cis 2,3,4,5,6-pentafluorocyclohexyl motifs

scientific article

Synthesis and elaboration of all-cis-1,2,4,5-tetrafluoro-3-phenylcyclohexane: a polar cyclohexane motif

scientific article published on 16 April 2014

Synthesis and structure of large difluoromethylene containing alicycles by ring closing metathesis (RCM).

scientific article published on 28 October 2013

Synthesis of aryl α,α-difluoroethyl thioethers a novel structure motif in organic chemistry, and extending to aryl α,α-difluoro oxyethers

scientific article

Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes

scientific article published on 14 April 2020

The Synthesis and Evaluation of Fluoro-, Trifluoromethyl-, and Iodomuscimols as GABA Agonists.

scientific article

The difluoromethylene (CF2) group in aliphatic chains: Synthesis and conformational preference of palmitic acids and nonadecane containing CF2 groups

scientific article published on 6 January 2014

The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes.

scientific article published on 10 August 2012

The rare fluorinated natural products and biotechnological prospects for fluorine enzymology

scientific article published on January 2012

Total Synthesis of a Reported Fluorometabolite from Streptomyces sp. TC1 Indicates an Incorrect Assignment. The Isolated Compound Did Not Contain Fluorine

scientific article published on 21 May 2014

Two 3'-O-β-glucosylated nucleoside fluorometabolites related to nucleocidin in Streptomyces calvus ⬇️

scientific article published on 20 August 2019

Unexpected α,α'-difluoroethers from Ag(i)F and N-bromosuccinimide reactions of dibenzo[a,e]cyclooctatetraene

scientific article published on 01 November 2019

List of works by David O'Hagan

A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic [18 F]Fluorination for PET Imaging.

A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions.

A two-step fluorinase enzyme mediated (18)F labelling of an RGD peptide for positron emission tomography.

Acetyl Coenzyme A Analogues as Rationally Designed Inhibitors of Citrate Synthase

All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane

An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange

Analysis of CF···FC Interactions on Cyclohexane and Naphthalene Frameworks

Bis(trifluoromethyl)methylene addition to vinyl-terminated SAMs: a gas-phase C-C bond-forming reaction on a surface.

Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells.

Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of α(v)β(3) integrin receptor.

Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase

Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate ⬇️

Fluorinated Musk Fragrances: The CF2 Group as a Conformational Bias Influencing the Odour of Civetone and (R)-Muscone.

Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif. ⬇️

Fluorinated cyclopropanes: synthesis and chemistry of the aryl α,β,β-trifluorocyclopropane motif

Fluorinated liquid crystals: evaluation of selectively fluorinated facially polarised cyclohexyl motifs for liquid crystal applications.

Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif

Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif

Fluorine in fragrances: exploring the difluoromethylene (CF2) group as a conformational constraint in macrocyclic musk lactones

Fluorine-containing substituents: metabolism of the α,α-difluoroethyl thioether motif

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674.

Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus

Hyperconjugation Is the Source of Helicity in Perfluorinated n-Alkanes

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid†

Identification of fluorinases from streptomyces sp MA37, norcardia brasiliensis, and actinoplanes sp N902-109 by genome mining

Incorporation of [2H1]-(1R,2R)- and [2H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus ⬇️

Inter- and intramolecular CF···co interactions on aliphatic and cyclohexane carbonyl derivatives

Interaction of B12F122- with All-cis 1,2,3,4,5,6 Hexafluorocyclohexane in the Gas Phase

Janus Face Aspect of All-cis 1,2,3,4,5,6-Hexafluorocyclohexane Dictates Remarkable Anion and Cation Interactions In the Gas Phase.

Last-Step Enzymatic [(18) F]-Fluorination of Cysteine-Tethered RGD Peptides Using Modified Barbas Linkers

Lewis acid-promoted hydrofluorination of alkynyl sulfides to generate α-fluorovinyl thioethers.

Metabolism and hydrophilicity of the polarised 'Janus face' all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery.

Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.

Multicomponent reactions of methyl substituted all-cis tetrafluorocyclohexane aldehydes.

Organic chemistry on surfaces: Direct cyclopropanation by dihalocarbene addition to vinyl terminated self-assembled monolayers (SAMs)

Organo-fluorine chemistry III.

Organofluorine chemistry: Difluoromethylene motifs spaced 1,3 to each other imparts facial polarity to a cyclohexane ring.

Particularly strong C–H⋯π interactions between benzene and all-cis 1,2,3,4,5,6-hexafluorocyclohexane

Polar alicyclic rings: synthesis and structure of all cis-1,2,3,4-tetrafluorocyclopentane

Probing the helical integrity of multivicinal all-syn-fluoro alkanes

Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane

Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells.

Stepwise preparation of all-cis 1,3,4-trifluoro-2-phenylcyclohexane, avoiding a phenonium intermediate

Stereochemical outcomes of C-F activation reactions of benzyl fluoride.

Stereoselective alpha-fluoroamide and alpha-fluoro-gamma-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement.

Supramolecular packing of alkyl substituted Janus face all-cis 2,3,4,5,6-pentafluorocyclohexyl motifs

Synthesis and elaboration of all-cis-1,2,4,5-tetrafluoro-3-phenylcyclohexane: a polar cyclohexane motif

Synthesis and structure of large difluoromethylene containing alicycles by ring closing metathesis (RCM).

Synthesis of aryl α,α-difluoroethyl thioethers a novel structure motif in organic chemistry, and extending to aryl α,α-difluoro oxyethers

Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes

The Synthesis and Evaluation of Fluoro-, Trifluoromethyl-, and Iodomuscimols as GABA Agonists.

The difluoromethylene (CF2) group in aliphatic chains: Synthesis and conformational preference of palmitic acids and nonadecane containing CF2 groups

The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes.

The rare fluorinated natural products and biotechnological prospects for fluorine enzymology

Total Synthesis of a Reported Fluorometabolite from Streptomyces sp. TC1 Indicates an Incorrect Assignment. The Isolated Compound Did Not Contain Fluorine

Two 3'-O-β-glucosylated nucleoside fluorometabolites related to nucleocidin in Streptomyces calvus ⬇️

Unexpected α,α'-difluoroethers from Ag(i)F and N-bromosuccinimide reactions of dibenzo[a,e]cyclooctatetraene