List of works - Jean C Manson

A novel, resistance-linked ovine PrP variant and its equivalent mouse variant modulate the in vitro cell-free conversion of rPrP to PrP(res)

scientific article published on 01 December 2006

A prion reduction filter does not completely remove endogenous prion infectivity from sheep blood.

scientific article published on 30 May 2015

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype

scientific article published on 22 July 2016

Accumulation of prion protein in the brain that is not associated with transmissible disease

scholarly article

All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD

scientific article (publication date: 2011)

Altered glycosylated PrP proteins can have different neuronal trafficking in brain but do not acquire scrapie-like properties.

scientific article

Analysis of gene expression in the nervous system identifies key genes and novel candidates for health and disease

scientific article published on 11 February 2017

Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain

scientific article

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

scientific article published on 15 June 2007

Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein.

scientific article published on 11 April 2012

Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.

scientific article published on 21 August 2017

Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases

article

Defining the Microglia Response during the Time Course of Chronic Neurodegeneration

scientific article published on 30 December 2015

Dissociation of prion protein amyloid seeding from transmission of a spongiform encephalopathy

scientific article published on 11 September 2013

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration

scientific article

Dramatic reduction of PrP C level and glycosylation in peripheral nerves following PrP knock-out from Schwann cells does not prevent transmissible spongiform encephalopathy neuroinvasion

scientific article published in December 2009

Effects of human PrPSc type and PRNP genotype in an in-vitro conversion assay

scientific article published in December 2008

Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen

scientific article published on December 2011

Glycosylation of PrPC determines timing of neuroinvasion and targeting in the brain following transmissible spongiform encephalopathy infection by a peripheral route

scientific article published on 27 January 2010

High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo.

scientific article

Host PrP glycosylation: a major factor determining the outcome of prion infection

scientific article

Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro

scientific article

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner

scientific article published on 15 November 2017

Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes

scientific article

In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc.

scientific article

Increased susceptibility of human-PrP transgenic mice to bovine spongiform encephalopathy infection following passage in sheep.

scientific article

Increased susceptibility of transgenic mice expressing human PrP to experimental sheep bovine spongiform encephalopathy is not due to increased agent titre in sheep brain tissue.

scientific article

Insights into Mechanisms of Chronic Neurodegeneration

scientific article

MM2-thalamic Creutzfeldt-Jakob disease: neuropathological, biochemical and transmission studies identify a distinctive prion strain.

scientific article published on 21 February 2012

Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice

scientific article

Mechanism of PrP-amyloid formation in mice without transmissible spongiform encephalopathy.

scientific article published on 25 July 2011

Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons

scientific article (publication date: 2005)

Molecular barriers to zoonotic transmission of prions

scientific article published on January 2014

Molecular model of prion transmission to humans

scientific article

No major change in vCJD agent strain after secondary transmission via blood transfusion

scientific article

Polymorphisms at codons 108 and 189 in murine PrP play distinct roles in the control of scrapie incubation time.

scientific article

Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties ⬇️

scientific article published on February 8, 2013

Predicting susceptibility and incubation time of human-to-human transmission of vCJD.

scientific article published in May 2006

Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease

scientific article published on 28 February 2013

Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.

scientific article

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

scientific article

Public health risks from subclinical variant CJD.

scientific article published on 30 November 2017

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology

scientific article published on 03 January 2017

The glycosylation status of PrPC is a key factor in determining transmissible spongiform encephalopathy transmission between species

scientific article

The role of host PrP in Transmissible Spongiform Encephalopathies.

scientific article published on 26 October 2006

Variably protease-sensitive prionopathy, a unique prion variant with inefficient transmission properties

scientific article

Variant CJD. 18 years of research and surveillance

scientific article

alpha-Hemoglobin stabilizing protein is not a suitable marker for a screening test for variant Creutzfeldt-Jakob disease.

scientific article published on 22 May 2008

List of works by Jean C Manson

A novel, resistance-linked ovine PrP variant and its equivalent mouse variant modulate the in vitro cell-free conversion of rPrP to PrP(res)

A prion reduction filter does not completely remove endogenous prion infectivity from sheep blood.

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype

Accumulation of prion protein in the brain that is not associated with transmissible disease

All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD

Altered glycosylated PrP proteins can have different neuronal trafficking in brain but do not acquire scrapie-like properties.

Analysis of gene expression in the nervous system identifies key genes and novel candidates for health and disease

Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein.

Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.

Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases

Defining the Microglia Response during the Time Course of Chronic Neurodegeneration

Dissociation of prion protein amyloid seeding from transmission of a spongiform encephalopathy

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration

Dramatic reduction of PrP C level and glycosylation in peripheral nerves following PrP knock-out from Schwann cells does not prevent transmissible spongiform encephalopathy neuroinvasion

Effects of human PrPSc type and PRNP genotype in an in-vitro conversion assay

Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen

Glycosylation of PrPC determines timing of neuroinvasion and targeting in the brain following transmissible spongiform encephalopathy infection by a peripheral route

High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo.

Host PrP glycosylation: a major factor determining the outcome of prion infection

Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner

Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes

In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc.

Increased susceptibility of human-PrP transgenic mice to bovine spongiform encephalopathy infection following passage in sheep.

Increased susceptibility of transgenic mice expressing human PrP to experimental sheep bovine spongiform encephalopathy is not due to increased agent titre in sheep brain tissue.

Insights into Mechanisms of Chronic Neurodegeneration

MM2-thalamic Creutzfeldt-Jakob disease: neuropathological, biochemical and transmission studies identify a distinctive prion strain.

Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice

Mechanism of PrP-amyloid formation in mice without transmissible spongiform encephalopathy.

Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons

Molecular barriers to zoonotic transmission of prions

Molecular model of prion transmission to humans

No major change in vCJD agent strain after secondary transmission via blood transfusion

Polymorphisms at codons 108 and 189 in murine PrP play distinct roles in the control of scrapie incubation time.

Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties ⬇️

Predicting susceptibility and incubation time of human-to-human transmission of vCJD.

Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease

Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

Public health risks from subclinical variant CJD.

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology

The glycosylation status of PrPC is a key factor in determining transmissible spongiform encephalopathy transmission between species

The role of host PrP in Transmissible Spongiform Encephalopathies.

Variably protease-sensitive prionopathy, a unique prion variant with inefficient transmission properties

Variant CJD. 18 years of research and surveillance

alpha-Hemoglobin stabilizing protein is not a suitable marker for a screening test for variant Creutzfeldt-Jakob disease.