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List of works by Patrick J Tighe

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)

scientific article

A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing

scientific article published on 28 August 2017

A thermoreversible hydrogel as a biosynthetic bandage for corneal wound repair.

scientific article

Age differences in cytokine expression under conditions of health using experimental pain models

scientific article

Altered cytokine pattern and inflammatory pathways in monogenic and complex autoinflammatory diseases.

scientific article

Amniotic membrane for ocular surface reconstruction: donor variations and the effect of handling on TGF-beta content.

scientific article

Analysis of genetic variation in isolates of Trichinella using random amplified polymorphic DNA

scientific article published on 01 January 1994

Analysis of the T-cell receptor beta chain repertoire expressed in endogenous posterior uveitis

scientific article published on 01 July 1995

Antibodies from systemic lupus erythematosus (SLE) sera define differential release of autoantigens from cell lines undergoing apoptosis

scientific article published on 01 November 1999

Antimicrobial defensin peptides of the human ocular surface

scientific article published on June 1999

Astrocytes as antigen-presenting cells: expression of IL-12/IL-23

scientific article published on 08 August 2005

Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease

scientific article published on 23 September 2017

Cell surface expression of TNFRI in tumor necrosis factor receptor-associated periodic syndrome: comment on the article by Nedjai et al.

scientific article

Characterization of Behavioral, Signaling and Cytokine Alterations in a Rat Neurodevelopmental Model for Schizophrenia, and Their Reversal by the 5-HT6 Receptor Antagonist SB-399885.

scientific article published on 8 February 2018

Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer

scientific article

Clinical utility of reverse phase protein array for molecular classification of breast cancer

scientific article published on 09 December 2015

Clinicopathological significance of KU70/KU80, a key DNA damage repair protein in breast cancer

scientific article published on 28 April 2013

Co-Transcriptomes of Initial Interactions In Vitro between Streptococcus Pneumoniae and Human Pleural Mesothelial Cells

scientific article published on 13 November 2015

Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics.

scientific article

Deciphering the contribution of human meningothelial cells to the inflammatory and antimicrobial response at the meninges

scientific article published on 3 September 2013

Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse transcription polymerase chain reaction.

scientific article published in November 1999

Development and validation of protein microarray technology for simultaneous inflammatory mediator detection in human sera.

scientific article published on 14 October 2014

Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD).

scientific article

ELISA in the multiplex era: potentials and pitfalls.

scientific article

Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells

scientific article

Elevated CD16 expression by monocytes from patients with tumor necrosis factor receptor-associated periodic syndrome

scientific article published in December 2007

Epithelial mesenchymal transition in early invasive breast cancer: an immunohistochemical and reverse phase protein array study

scientific article published on 26 April 2014

Ex vivo and in vitro production of pro-inflammatory cytokines in Blau syndrome.

scientific article published on 31 March 2015

Expression of CD34 and L-selectin on human corneal keratocytes.

scientific article published in November 2003

Functional consequences of disease-associated mutations in TNFR1 elucidated by transcriptome analysis.

scientific article published on January 2011

HIV coreceptor and chemokine ligand gene expression in the male urethra and female cervix.

scientific article published on August 2005

Heterogeneity of tumor necrosis factor receptor-associated periodic syndrome: comment on the article by Siebert et al

scientific article published on 01 September 2005

Human chitotriosidase is expressed in the eye and lacrimal gland and has an antimicrobial spectrum different from lysozyme.

scientific article published on 22 October 2007

Human conjunctiva contains high endothelial venules that express lymphocyte homing receptors

scientific article published on 01 October 1999

IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review

scientific article

Immune deficiency in Ataxia-Telangiectasia: a longitudinal study of 44 patients.

scientific article published in May 2014

Immunocytochemical study of Peyer's patches follicular-associated epithelium in the marsupial, Didelphis albiventris

scientific article published on 01 November 1993

Inactivation of the Fas gene by Alu insertion: retrotransposition in an intron causing splicing variation and autoimmune lymphoproliferative syndrome.

scientific article published in October 2002

Innate defence of the eye by antimicrobial defensin peptides ⬇️

scientific article published on August 8, 1998

Internal standard-based analysis of microarray data2--analysis of functional associations between HVE-genes

scientific article

Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy

scientific article

KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer

scientific article

Mammalian cell survival and processing in supercritical CO(2)

scholarly article

Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function.

scientific article

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease.

scientific article published on 25 July 2016

Multiple protein extract microarray for profiling human food-specific immunoglobulins A, M, G and E.

scientific article

Mutant forms of tumour necrosis factor receptor I that occur in TNF-receptor-associated periodic syndrome retain signalling functions but show abnormal behaviour.

scientific article published on September 2004

Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor-associated periodic syndrome is altered antigenically and is retained within patients' leukocytes

scientific article published on August 2007

Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease

scientific article

Optimised two-dimensional electrophoresis procedures for the protein characterisation of structural tissues.

scientific article published in May 2005

PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline

scientific article

Patients with tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) are hypersensitive to Toll-like receptor 9 stimulation

scientific article published on 22 May 2019

Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction

scientific article published on 13 October 2016

Positive mood on the day of influenza vaccination predicts vaccine effectiveness: A prospective observational cohort study.

scientific article published on 15 September 2017

Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis ⬇️

scientific article

Prognostic and biological significance of peroxisome proliferator-activated receptor-gamma in luminal breast cancer.

scientific article published on 21 March 2015

Quantitative analysis of IL-10 and IFN-gamma mRNA levels in normal cervix and human papillomavirus type 16 associated cervical precancer.

scientific article

Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis.

scientific article

Reinfection with hookworm after chemotherapy in Papua New Guinea. ⬇️

scientific article

Restrictions of T cell receptor beta chain repertoire in the peripheral blood of patients with systemic lupus erythematosus

scientific article

Retroviral activity in Behçet's syndrome and systemic lupus erythematosus detected by a PCR-based reverse transcriptase assay

scientific article published on 01 October 2001

Role of interleukin-6 in a patient with tumor necrosis factor receptor-associated periodic syndrome: assessment of outcomes following treatment with the anti-interleukin-6 receptor monoclonal antibody tocilizumab.

scientific article published on April 2011

S antigen specific effector T cell activation detected by cytokine flow cytometry.

scientific article published on May 2002

SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells

scientific article published on 16 September 2016

SUMOylation proteins in breast cancer

scientific article published on March 2014

Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: differences between cell types

scientific article published on August 2004

TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome

scientific article published on 4 October 2012

The Arabidopsis MALE STERILITY1 (MS1) gene is a transcriptional regulator of male gametogenesis, with homology to the PHD-finger family of transcription factors.

scientific article published on October 2001

The application of protein microarray assays in psychoneuroimmunology

scientific article published on 14 September 2016

The intracellular signalling pathway signature (the signalome) in PBMCs in the presence of a common TRAPS-associated genetic variant, TNFRSF1A p.(Arg121Gln) (legacy p.R92Q) is distinct from normal PBMCs and from other pathogenic variants.

scientific article

The mammalian target of rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways

scientific article

The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity

scientific article published on 7 July 2010

The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization

scientific article

The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathway

scientific article published on 3 April 2015

The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts

scientific article

The spectrum of antimicrobial peptide expression at the ocular surface.

scientific article published in April 2005

Treatment of Erdheim-Chester disease with cladribine: a rational approach

scientific article

Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome

scientific article published on 23 July 2015

Utility, reliability and reproducibility of immunoassay multiplex kits.

scientific article published on 16 January 2013

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