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List of works by Penelope D Ottewell

A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells

scientific article published on 31 January 2020

A single administration of combination therapy inhibits breast tumour progression in bone and modifies both osteoblasts and osteoclasts.

scientific article

Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone.

scientific article published on 29 September 2009

Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer.

scientific article published on 11 August 2008

Bone Metastasis: Molecular Mechanisms Implicated in Tumour Cell Dormancy in Breast and Prostate Cancer

scientific article published on 05 May 2015

CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment ⬇️

scientific article published on 12 January 2016

Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine

scientific article published on 01 October 2001

Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone.

scientific article

Combination therapy inhibits development and progression of mammary tumours in immunocompetent mice

article

Combined therapies of bone disease with bisphosphonates.

scientific article published on January 2010

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

scientific article published on 29 November 2019

Different molecular profiles are associated with breast cancer cell homing compared with colonisation of bone: evidence using a novel bone-seeking cell line

scientific article published on 7 March 2014

Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo.

scientific article published in July 2008

Erratum to: Loss of plakoglobin promotes cell-cell contact, increased invasion and breast cancer cell dissemination in vivo

scientific article published on 28 March 2017

Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions.

scientific article published in August 2015

IL-1 drives breast cancer growth and bone metastasis in vivo.

scientific article published on 27 September 2016

Imaging apoptosis in vivo using 124I-annexin V and PET.

scientific article published in May 2005

Location matters: osteoblast and osteoclast distribution is modified by the presence and proximity to breast cancer cells in vivo ⬇️

scientific article published on May 6, 2012

Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo ⬇️

scientific article published on May 25, 2012

Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.

scientific article

MBP-annexin V radiolabeled directly with iodine-124 can be used to image apoptosis in vivo using PET.

scientific article published in April 2005

Macrophages as potential targets for zoledronic acid outside the skeleton-evidence from in vitro and in vivo models

scientific article published on 01 November 2013

Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid.

scientific article published on 13 May 2008

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

scientific article published on 01 November 2019

Mitotic quiescence, but not unique "stemness," marks the phenotype of bone metastasis-initiating cells in prostate cancer.

scientific article published on 17 April 2015

Molecular alterations that drive breast cancer metastasis to bone

scientific article

Murine models of breast cancer bone metastasis

scientific article

OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone.

scientific article published on 2 February 2015

Oestrogen receptor positive breast cancer metastasis to bone: inhibition by targeting the bone microenvironment in vivo.

scientific article published on 19 November 2015

Pretreatment of breast cancer cells with doxorubicin facilitates the subsequent uptake of zoledronic acid.

scientific article published on 13 May 2008

Progastrin stimulates murine colonic epithelial mitosis after DNA damage

scientific article published on 01 May 2003

Prostate cancer cells preferentially home to osteoblast-rich areas in the early stages of bone metastasis: evidence from in vivo models

scientific article

Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model.

scientific article

Synergistic effects of cytotoxic drugs and antiresorptive agents in vitro and in vivo.

scientific article published in November 2006

The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway

scientific article

The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer

scientific article

The role of osteoblasts in bone metastasis

scientific article published on 13 April 2016

Zoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo

scientific article

Zoledronic acid-induced IPP/ApppI production in vivo

scientific article published on 17 August 2007

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