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List of works by Alvin Lu

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

scientific article published on 11 April 2016

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

scientific article

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1

article published in the Proceedings of the National Academy of Sciences of the United States of America

Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions

scientific article

Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.

scientific article

Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation

scientific article

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.

scientific article

Molecular mechanism for NLRP6 inflammasome assembly and activation

scientific article published on 23 January 2019

Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.

scientific article

SERPINB1-mediated checkpoint of inflammatory caspase activation

scientific article published on 28 January 2019

Structural and Functional Studies of Aspergillus oryzae Cutinase: Enhanced Thermostability and Hydrolytic Activity of Synthetic Ester and Polyester Degradation

scientific article

Structural mechanisms of inflammasome assembly

scientific article

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments

scientific article

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

scientific article

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