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List of works by Lynda Coughlan

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice

scientific article published on 19 April 2020

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

scientific article published on 07 December 2020

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery

scientific article

Adenoviral vectors as novel vaccines for influenza.

scientific article

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

scientific article published on 22 May 2012

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

scientific article

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

scientific article published on 23 December 2021

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

scientific article published in 2021

ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome

scientific article published on 01 December 2021

Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens

scientific article published on 30 December 2013

Coadministration of seasonal influenza vaccine and MVA-NP+M1 simultaneously achieves potent humoral and cell-mediated responses

scientific article published on 08 July 2013

Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

scientific article

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection

scientific article published on 06 July 2020

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection

scientific article published on 17 October 2020

Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum

scientific article

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies

scientific article published on 09 November 2020

Differential immunogenicity between HAdV-5 and chimpanzee adenovirus vector ChAdOx1 is independent of fiber and penton RGD loop sequences in mice

scientific article

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

scientific article published in Nature Communications

Gene delivery of a mutant TGFβ3 reduces markers of scar tissue formation after cutaneous wounding

scientific article

Genetically engineering adenoviral vectors for gene therapy.

scientific article published on January 2014

Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults.

scientific article

In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.

scientific article published on 15 April 2009

Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model

scientific article published on 17 September 2020

Measuring Cellular Immunity to Influenza: Methods of Detection, Applications and Challenges

scientific article

Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine

scientific article published on 01 July 2018

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

scientific article published on 17 October 2020

Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans

scientific article published on 01 December 2020

Pseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies.

scientific article published on April 2016

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

scientific article

Retargeting adenovirus serotype 48 fiber knob domain by peptide incorporation

scientific article published on 11 April 2014

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

scientific article published on 23 October 2020

Targeting Antigen to the Surface of EVs Improves the In Vivo Immunogenicity of Human and Non-human Adenoviral Vaccines in Mice

scientific article published on 24 December 2019

The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells.

scientific article published on 24 January 2018

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

scientific article

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