List of works - Piotr Ruchala

4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.

scientific article published on 21 July 2017

A compensatory mutation provides resistance to disparate HIV fusion inhibitor peptides and enhances membrane fusion

scientific article

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.

scientific article published on 18 February 2009

Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I.

scientific article published on 11 July 2008

Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation

scientific article

Conformation and Trimer Association of the Transmembrane Domain of the Parainfluenza Virus Fusion Protein in Lipid Bilayers from Solid-State NMR: Insights into the Sequence Determinants of Trimer Structure and Fusion Activity

scientific article published on 9 January 2018

Context mediates antimicrobial efficacy of kinocidin congener peptide RP-1

scientific article

Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs.

scientific article

Cyclic peptide interleukin 5 antagonists mimic CD turn recognition epitope for receptor alpha.

scientific article published in April 2004

Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.

scientific article

Functional importance of the NH2-terminal insertion sequence of lung surfactant protein B.

scientific article

G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis.

scientific article published on 09 July 2008

Grifonin-1: a small HIV-1 entry inhibitor derived from the algal lectin, Griffithsin

scientific article (publication date: 16 December 2010)

Hapivirins and diprovirins: novel θ-defensin analogs with potent activity against influenza A virus.

scientific article

Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells.

scientific article published on 14 October 2016

Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus

scientific article published on January 2015

Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections

scientific article

Identification of novel small-molecule inhibitors of Zika virus infection

scientific article published on 9 December 2017

Inhibitors of HIV-1 entry.

scientific article published on January 2013

Insights into the structure and molecular topography of the fatty acylated domain of synaptotagmin-1

scientific article published on 04 January 2019

KL₄ peptide induces reversible collapse structures on multiple length scales in model lung surfactant

scientific article published on 20 December 2011

Lateral stress relaxation and collapse in lipid monolayers

scientific article

Membrane-bound dynamic structure of an arginine-rich cell-penetrating peptide, the protein transduction domain of HIV TAT, from solid-state NMR.

scientific article

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

scientific article published on December 2011

Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models.

scientific article published on 23 October 2017

Novel dimeric Smac analogs as prospective anticancer agents.

scientific article

Optimization of 1,3-disubstituted urea-based inhibitors of Zika virus infection

scientific article published on 20 August 2019

Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids

scientific article (publication date: 14 April 2010)

Position of lipidation influences anticancer activity of Smac analogs

scientific article published on 26 April 2019

Quantitative Measure of Intestinal Permeability Using Blue Food Coloring

scientific article published on 27 July 2018

Reawakening retrocyclins: ancestral human defensins active against HIV-1

scientific article

Roles of arginine and lysine residues in the translocation of a cell-penetrating peptide from (13)C, (31)P, and (19)F solid-state NMR.

scientific article published on June 2009

Small cyclic agonists of iron regulatory hormone hepcidin

scientific article published on 12 March 2015

Structural and functional properties of peptides based on the N-terminus of HIV-1 gp41 and the C-terminus of the amyloid-beta protein.

scientific article published on 11 May 2008

Structures of β-hairpin antimicrobial protegrin peptides in lipopolysaccharide membranes: mechanism of gram selectivity obtained from solid-state nuclear magnetic resonance.

scientific article

Surfactant protein C peptides with salt-bridges ("ion-locks") promote high surfactant activities by mimicking the α-helix and membrane topography of the native protein

scientific article published on 15 July 2014

The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation

scientific article published on 07 February 2019

The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques

scientific article

The pathophysiology and pharmacology of hepcidin.

scientific article published on 17 February 2014

Thiol-derivatized minihepcidins retain biological activity.

scientific article published on 6 January 2015

Uncovering the Mechanism of Aggregation of Human Transthyretin

scientific article

alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s).

scientific article published on 10 August 2007

List of works by Piotr Ruchala

4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.

A compensatory mutation provides resistance to disparate HIV fusion inhibitor peptides and enhances membrane fusion

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.

Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I.

Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation

Conformation and Trimer Association of the Transmembrane Domain of the Parainfluenza Virus Fusion Protein in Lipid Bilayers from Solid-State NMR: Insights into the Sequence Determinants of Trimer Structure and Fusion Activity

Context mediates antimicrobial efficacy of kinocidin congener peptide RP-1

Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs.

Cyclic peptide interleukin 5 antagonists mimic CD turn recognition epitope for receptor alpha.

Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.

Functional importance of the NH2-terminal insertion sequence of lung surfactant protein B.

G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis.

Grifonin-1: a small HIV-1 entry inhibitor derived from the algal lectin, Griffithsin

Hapivirins and diprovirins: novel θ-defensin analogs with potent activity against influenza A virus.

Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells.

Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus

Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections

Identification of novel small-molecule inhibitors of Zika virus infection

Inhibitors of HIV-1 entry.

Insights into the structure and molecular topography of the fatty acylated domain of synaptotagmin-1

KL₄ peptide induces reversible collapse structures on multiple length scales in model lung surfactant

Lateral stress relaxation and collapse in lipid monolayers

Membrane-bound dynamic structure of an arginine-rich cell-penetrating peptide, the protein transduction domain of HIV TAT, from solid-state NMR.

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models.

Novel dimeric Smac analogs as prospective anticancer agents.

Optimization of 1,3-disubstituted urea-based inhibitors of Zika virus infection

Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids

Position of lipidation influences anticancer activity of Smac analogs

Quantitative Measure of Intestinal Permeability Using Blue Food Coloring

Reawakening retrocyclins: ancestral human defensins active against HIV-1

Roles of arginine and lysine residues in the translocation of a cell-penetrating peptide from (13)C, (31)P, and (19)F solid-state NMR.

Small cyclic agonists of iron regulatory hormone hepcidin

Structural and functional properties of peptides based on the N-terminus of HIV-1 gp41 and the C-terminus of the amyloid-beta protein.

Structures of β-hairpin antimicrobial protegrin peptides in lipopolysaccharide membranes: mechanism of gram selectivity obtained from solid-state nuclear magnetic resonance.

Surfactant protein C peptides with salt-bridges ("ion-locks") promote high surfactant activities by mimicking the α-helix and membrane topography of the native protein

The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation

The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques

The pathophysiology and pharmacology of hepcidin.

Thiol-derivatized minihepcidins retain biological activity.

Uncovering the Mechanism of Aggregation of Human Transthyretin

alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s).